Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Pablo Helguera"'
Autor:
Jorge Busciglio, Ryan C. Bohannan, Pablo Helguera, Jean Thomas, Eric Doran, Schriner E. Samuel, Jocelyn Argueta, Zahra Nemati, Pinar Coskun, Douglas C. Wallace, Ira T. Lott
Deficits in mitochondrial function and oxidative stress play pivotal roles in Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria occur systemically in both conditions. Objective: We hypothesized that peripheral cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2171022e7666a0906d14bb572d2c6820
https://www.ncbi.nlm.nih.gov/pubmed/27802222
https://www.ncbi.nlm.nih.gov/pubmed/27802222
Autor:
José de Olmos, Frank M. LaFerla, Soledad de Olmos, Francisco Solá Vigo, Gabriela Kedikian, Alfredo Cáceres, Matthias Staufenbiel, Alfredo Lorenzo, Pablo Helguera, Lorena Heredia, Jorge Busciglio
Publikováno v:
Journal of Neuroscience. 26:6533-6542
Deposition of fibrillar amyloid beta (fAbeta) plays a critical role in Alzheimer's disease (AD). We have shown recently that fAbeta-induced dystrophy requires the activation of focal adhesion proteins and the formation of aberrant focal adhesion stru
Autor:
Jorge Busciglio, Pablo Helguera, Elizabeth Head, Alejandra Pelsman, Ernst J. Wolvetang, Gustavo Pigino
Publikováno v:
The Journal of Neuroscience. 25:2295-2303
Down's syndrome (DS) is characterized by mental retardation and development of Alzheimer's disease (AD). Oxidative stress and mitochondrial dysfunction are both related to neurodegeneration in DS. Several genes in chromosome 21 have been linked to ne
Publikováno v:
Journal of Visualized Experiments : JoVE
In this study, we outline a standardized protocol for the successful cryopreservation and thawing of cortical brain tissue blocks to generate highly enriched neuronal cultures. For this protocol the freezing medium used is 10% dimethyl sulfoxide (DMS