Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael J. Owens"'
Autor:
Eric P. Smith, Leonard A. Rosenblum, Shariful A. Syed, Michael J. Owens, Olcay Batuman, Charles B. Nemeroff, Jeremy D. Coplan
Publikováno v:
Neuroscience Letters. 647:20-25
Introduction Early life stress (ELS) has been shown to play a role in establishing persistent maladaptive HPA axis modifications that may contribute to the pathogenesis of mood and anxiety disorders. Central glucocorticoid receptor (GR) messenger RNA
Publikováno v:
The Journal of Neuroscience. 24:9303-9312
Corticotropin-releasing factor (CRF) is the major physiologic regulator of the hypothalamic-pituitary-adrenal (HPA) axis and plays a key role in coordinating the mammalian stress response. Substantial data implicates hyperactivity of CRF neuronal sys
Publikováno v:
The Journal of Neuroscience. 20:1240-1248
In view of the substantial preclinical evidence that supports a seminal role of central corticotropin-releasing factor (CRF) neuronal systems in the physiology and pathophysiology of stress and anxiety, it is reasonable to suggest that the anxiolytic
Publikováno v:
The Neuroscientist. 3:186-194
Corticotropin-releasing factor (CRF), a 41 amino acid-containing neuropeptide, acts both as a hypothalamic releasing factor, controlling ACTH and corticosteroid secretion, and at extrahypothalamic CNS sites to mod ulate mammalian organisms' responses
Publikováno v:
Annals of the New York Academy of Sciences. 780:96-105
Autor:
Julie C. Stout, Mark F. Aaron, Jay M. Weiss, Michael J. Owens, Charles B. Nemeroff, Pamela D. Butler, Ning Quan
Publikováno v:
Brain Research Bulletin. 35:561-572
Based on studies of depression and anxiety using animal (rat) models, it is suggested that, contrary to a widely accepted theory, increased activity of locus coeruleus (LC) neurons does not appear to potentiate anxiety; instead, the influence of LC a
Autor:
Michael J. Owens, Charles B. Nemeroff
Publikováno v:
Nature Neuroscience. 5:1068-1070
Depression is a leading cause of morbidity and mortality, and its treatment includes a high percentage of the medications prescribed by physicians. Available antidepressant drugs are safe and effective, but less than half of all patients attain compl
Autor:
John G. Kral, Margaret Altemus, Leonard A. Rosenblum, Tarique D. Perera, Jack M. Gorman, Eric L. Smith, Michael J. Owens, Sanjay J. Mathew, Charles B. Nemeroff, Jeremy D. Coplan
Publikováno v:
Annals of the New York Academy of Sciences. 1071
The maternal stress response may vary as a function of infant developmental phase. Using a median split, 13 bonnet macaque (M. radiata) mother-infant dyads were exposed to early initiation of variable foraging demand (VFD), a prolonged stressor, wher
Dopamine receptor agonist and NMDA receptor antagonist activation of the mesolimbic dopamine system increases locomotion and disrupts prepulse inhibition of the acoustic startle response (PPI), paradigms frequently used to study both the pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c513f23f56ccbda26334df9512fd7f9e
https://europepmc.org/articles/PMC6726044/
https://europepmc.org/articles/PMC6726044/
Publikováno v:
Journal of neuroscience methods. 151(1)
This study exemplifies the use of three ADHD-relevant methodological innovations. (1) The use of novel, patented, computational peptide design techniques to generate peptides targeting the extra-cellular and para-transmembrane amino acid loops of the