Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Huaxin Sheng"'
A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice
Publikováno v:
Journal of Visualized Experiments.
Publikováno v:
Journal of Visualized Experiments.
Autor:
Zhuoran Wang, Wei Wang, Wei Yang, Xuan Li, Weiguo Zhang, Maorong Jiang, Huaxin Sheng, Jingjun Lyu, Ran Li, Jörn Karhausen
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundCardiac arrest (CA) is associated with high morbidity and mortality, even after spontaneous circulation is re-established. This dire situation is partly due to post-CA syndrome for which no specific and effective intervention is available.
Autor:
Xuan Li, Jingjun Lyu, Ran Li, Vaibhav Jain, Yuntian Shen, Ángela del Águila, Ulrike Hoffmann, Huaxin Sheng, Wei Yang
Publikováno v:
Journal of neuroinflammation. 19(1)
Background Ischemic stroke is a medical emergency that primarily affects the elderly. A complex immune response in the post-stroke brain constitutes a key component of stroke pathophysiology. This study aimed to determine how stroke affects immune ce
Publikováno v:
Brain research bulletin. 183
Ischemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, an
Autor:
Huaxin Sheng, Ying Li, Wulf Paschen, Xiaozhi Liu, Shuai Liu, David S. Warner, Lin Zhang, Wei Yang, Julia Q. Zhao
Publikováno v:
Neuroscience. 343:190-212
Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic
Autor:
Miaomiao Lu, Jun Hong, Victoria Jones, Somnath Mukhopadhyay, David S. Warner, Vijaya B. Nandiwada, Huaxin Sheng
Publikováno v:
Neuroscience Letters. 597:19-24
Increased matrix metalloproteinase (MMP) activity contributes to glial scar formation that inhibits the repair path after spinal cord injury (SCI). We examined whether treatment with N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraena
Publikováno v:
Translational stroke research. 7(5)
Anesthetics have enabled major advances in development of experimental models of human stroke. Yet, their profound pharmacologic effects on neural function can confound the interpretation of experimental stroke research. Anesthetics have species-, dr
Autor:
Frederick W. Lombard, Gavin W. Britz, Huaxin Sheng, David S. Warner, Wei Yang, Zhengfeng Wang
Publikováno v:
Journal of Neuroscience Methods. 189:246-251
Use of genetically manipulated mice facilitates understanding pathological mechanisms in many diseases and contributes to therapy development. However, there is no practical and clinically relevant mouse model available for spinal cord ischemia. This
Autor:
Claude A. Piantadosi, Huaxin Sheng, Hagir B. Suliman, David S. Warner, Jessica D. McAdoo, John J. Freiberger
Publikováno v:
Brain Research. 1075:213-222
The potency of hyperbaric preconditioning (HBO-PC) is uncertain compared to well-validated ischemic or hypoxic models and no studies have directly compared HBO-PC to hypoxic preconditioning (HPC). We subjected rat pups to unilateral carotid cauteriza