Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Bruce R. Ransom"'
Autor:
Davin Gong, Jonathan R. Weinstein, Jamie R. Colman, Thu Le, Richard V. Lee, Margaret A. Hamner, Bruce R. Ransom, Zucheng Ye
Publikováno v:
The Journal of Neuroscience. 35:15599-15611
Ischemic preconditioning (IPC) is a robust neuroprotective phenomenon whereby brief ischemic exposure confers tolerance to a subsequent ischemic challenge. IPC has not been studied selectively in CNS white matter (WM), although stroke frequently invo
Autor:
Nancy Ann Oberheim, Takahiro Takano, Xiaoning Han, Wei He, Jane H. C. Lin, Fushun Wang, Qiwu Xu, Jeffrey D. Wyatt, Webster Pilcher, Jeffrey G. Ojemann, Bruce R. Ransom, Steven A. Goldman, Maiken Nedergaard
Publikováno v:
The Journal of Neuroscience. 29:3276-3287
Defining the microanatomic differences between the human brain and that of other mammals is key to understanding its unique computational power. Although much effort has been devoted to comparative studies of neurons, astrocytes have received far les
Autor:
Selva Baltan, Brianna Mbow, Zu Cheng Ye, Bruce R. Ransom, Margaret A. Hamner, Elaine Besancon
Publikováno v:
The Journal of Neuroscience. 28:1479-1489
Stroke incidence increases with age and this has been attributed to vascular factors. We show here that CNS white matter (WM) is intrinsically more vulnerable to ischemic injury in older animals and that the mechanisms of WM injury change as a functi
Autor:
Yiheng Xie, Stephanie Balcaitis, Henrik Andersen, Bruce R. Ransom, Jonathan R. Weinstein, Thomas Möller, Uwe Karsten Hanisch
Publikováno v:
NeuroReport. 14:2373-2377
Microglia are the resident immune cells of the CNS: they are activated rapidly by CNS damage and perform the function of tissue macrophages. The first steps during microglial activation are currently under intense study, and it is widely believed tha
Publikováno v:
The Journal of Neuroscience. 23:3588-3596
Little is known about the expression and possible functions of unopposed gap junction hemichannels in the brain. Emerging evidence suggests that gap junction hemichannels can act as stand-alone functional channels in astrocytes. With immunocytochemis
Publikováno v:
NeuroReport. 10:2929-2932
Oligodendrocytes are the myelin forming glial cells of the CNS and are known to express receptors linked to ion channels and intracellular second messenger cascades. In this paper, we describe the intracellular calcium responses of cells from the oli
Autor:
Raymond A. Swanson, Kevin Farrell, Maria C. Longuemare, Stephen G. Waxman, Christine R. Rose, Bruce R. Ransom
Publikováno v:
Neuroscience. 93:285-292
Glutamate uptake is coupled to counter-transport of K+, and high external K+ concentrations can induce reversal of glutamate uptake in whole-cell patch-clamp and isolated membrane preparations. However, high external K+ causes little or no reversal o
Publikováno v:
Europe PubMed Central
Rose, Christine R., Bruce R. Ransom, and Stephan G. Waxman. Pharmacological characterization of Na+influx via voltage-gated Na+channels in spinal cord astrocytes. J. Neurophysiol. 78: 3249–3258, 1997. Spinal cord astrocytes display a high density o
Publikováno v:
Molecular and Chemical Neuropathology. 27:107-129
Anoxia/ischemia in the CNS is a common and devastating phenomenon. It is possible that the best hopes for protection against anoxic/ischemic injury may involve recruiting and/or augmenting any autoprotective systems that evolution has provided for th
Publikováno v:
Brain Research. 706:210-216
It is generally known that hyperventilation produces an increase in neuronal excitability. However, the mechanism whereby a change in CO2 partial pressure (Pco2) leads to changes in neural excitability is not known. We have studied this phenomenon in