Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander M. Binshtok"'
Autor:
Devora Gershon, Robert H. Negev-Goldstein, Lama Abd al Razzaq, Shaya Lev, Alexander M. Binshtok
Publikováno v:
STAR Protocols. 3:101224
Publikováno v:
J Neurosci
The output from the peripheral terminals of primary nociceptive neurons, which detect and encode the information regarding noxious stimuli, is crucial in determining pain sensation. The nociceptive terminal endings are morphologically complex structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5bcd28c28e3989d9f088be56c25e69
https://doi.org/10.1101/2020.07.30.228015
https://doi.org/10.1101/2020.07.30.228015
Publikováno v:
Journal of Neurophysiology. 113:601-619
Tetrodotoxin-resistant (TTX-r) sodium channels are key players in determining the input-output properties of peripheral nociceptive neurons. Changes in gating kinetics or in expression levels of these channels by proinflammatory mediators are likely
Autor:
Clifford J. Woolf, Felix Blasl, Jared M Sprague, Bo Duan, Haley A W Patoski, David Roberson, Sagi Gudes, Bruce P. Bean, Seog Bae Oh, Alexander M. Binshtok, Qiufu Ma, Victoria K. Robson
Publikováno v:
Nature Neuroscience. 16:910-918
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or d
Publikováno v:
Neuron. 21(5):1055-1065
In sensory areas of neocortex, thalamocortical afferents project primarily onto the spiny stellate neurons of Layer 4. Anatomical evidence indicates that these cells receive most of their excitatory input from other cortical neurons, including other
Autor:
Gui Lan Yao, Alexander M. Binshtok, Seog Bae Oh, Clifford J. Woolf, Michelino Puopolo, Bruce P. Bean
Publikováno v:
Journal of neurophysiology. 109(7)
QX-314 ( N-ethyl-lidocaine) is a cationic lidocaine derivative that blocks voltage-dependent sodium channels when applied internally to axons or neuronal cell bodies. Coapplication of external QX-314 with the transient receptor potential vanilloid 1
Autor:
Tarek A. Samad, Katharina Zimmermann, Theodore R. Cummins, Michael F. Jarvis, Sulayman D. Dib-Hajj, Alexander M. Binshtok
Publikováno v:
Brain research reviews. 60(1)
Pain is a major unmet medical need which has been causally linked to changes in sodium channel expression, modulation, or mutations that alter channel gating properties or current density in nociceptor neurons. Voltage-gated sodium channels activate
Autor:
Fumimasa Amaya, Alexander M. Binshtok, Clifford J. Woolf, Daniel Vardeh, Tarek A. Samad, Gary J. Brenner, Katharina Zimmermann, Bruce P. Bean, Haibin Wang, Ru-Rong Ji, Lin Shi
A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed tissue. This results from the local release by immune and injured cells of nociceptor sensitizers, including prostaglandin E2, bradykinin, and nerve growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a16c81deb9562856e475271f0577b56
https://europepmc.org/articles/PMC2690713/
https://europepmc.org/articles/PMC2690713/
Publikováno v:
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
In layer 4 of the somatosensory cortex, the glutamatergic synapses that interconnect spiny stellate (SpS) neurons, which are the major targets of thalamocortical input, differ from most other neocortical excitatory synapses in that they have an extre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a436e802f87341f52e4f440177248800
http://www.jneurosci.org/content/26/2/708
http://www.jneurosci.org/content/26/2/708