Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Abba, J."'
Autor:
Yi He, Yuxin Yu, Yanan Li, Weicheng Duan, Zuoli Sun, Jian Yang, Abba J. Kastin, Weihong Pan, Yan Zhang, Kang Wang
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2021)
Frontiers in Neuroscience, Vol 14 (2021)
BackgroundPrevious studies of the functions of IL15Rα have been limited to immune activities and skeletal muscle development. Immunological factors have been identified as one of the multiple causes of psychosis, and neurological symptoms have been
Autor:
Weihong Pan, Abba J. Kastin
Publikováno v:
The Neuroscientist. 23:124-136
Sleep and its disorders are known to affect the functions of essential organs and systems in the body. However, very little is known about how the blood-brain barrier (BBB) is regulated. A few years ago, we launched a project to determine the impact
Publikováno v:
The Journal of Neuroscience. 34:14697-14706
The blood–brain barrier (BBB) is a large regulatory and exchange interface between the brain and peripheral circulation. We propose that changes of the BBB contribute to many pathophysiological processes in the brain of subjects with chronic sleep
Autor:
Abba J. Kastin, Weihong Pan
Publikováno v:
CNSneurological disorders drug targets. 15(9)
Here we summarize three aspects of our understanding of the interactions of cytokines and neurotrophic peptides/proteins with the blood-brain and bloodspinal cord barriers (BBB): (a) pharmacokinetic analysis that has been reported for native cytokine
Autor:
Abba J. Kastin, Weihong Pan
Publikováno v:
CNSneurological disorders drug targets. 15(9)
Pertinent to pandemic obesity, the discovery of endogenous peptides that affect the ingestion of food has led to the question of how these ingestive peptides exert their actions in the brain. Whereas peripheral sources provide a ready reserve, the av
Autor:
Reas S. Khan, Weihong Pan, Bhavaani Jayaram, Hung Hsuchou, Eagle Yi-Kung Huang, Abba J. Kastin, Xiaojun Wu, Chu Chen
Publikováno v:
Annals of the New York Academy of Sciences
Leptin, an adipocyte-derived cytokine, crosses the blood–brain barrier to act on many regions of the central nervous system (CNS). It participates in the regulation of energy balance, inflammatory processes, immune regulation, synaptic formation, m
Autor:
Hung Hsuchou, Ji-Ming Feng, Yi He, Weihong Pan, Paul J. Pistell, Xiaojun Wu, Xiaochuan Guo, Abba J. Kastin, Zengbiao Li, Reas S. Khan, Wei-Hsung Wang
Publikováno v:
The Journal of Neuroscience. 30:4725-4734
Interleukin-15 (IL15) is a cytokine produced by normal brain, but the functions of the IL15 system in normal adults are not yet clear. The hypothesis that the hippocampal IL15 system is essential for memory consolidation was tested by use of IL15Rα
Publikováno v:
Experimental Brain Research. 156:224-230
Endomorphin-1 (EM-1) and endomorphin-2 (EM-2) are two highly selective mu-opiate receptor agonists. We recently demonstrated that EM-1 and EM-2 have a saturable transport system from brain-to-blood in vivo. Since the endothelial cells are the main co
Publikováno v:
Experimental Brain Research. 149:195-199
Brain trauma may alter the function of the blood-brain barrier (BBB) and affect psychomotor activity. We have shown that the transport system for tumor necrosis factor alpha (TNF alpha) at the BBB undergoes regulatory changes after spinal cord injury
Autor:
James E. Zadina, Abba J. Kastin, Qing-Ping Wang, Seiji Shioda, Jian-Lian Guan, Hisayuki Funahashi
Publikováno v:
Neuroscience. 113:593-605
Endomorphin-2 is a newly discovered endogenous opioid peptide with high affinity and selectivity for the μ-opioid receptor, and potent analgesic activity, particularly in the spinal cord. Using immunoelectron microscopy, we examined the ultrastructu