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Publikováno v:
Experimental Brain Research. 239:2435-2444
Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to
Publikováno v:
Brain Research Bulletin. 168:45-51
Background Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. However, the identity of the receptor(s) responsible for PGE2 regulation of neuronal activity and signaling
The Buspirone-dependent Abdominal Pain Transmission Within the Nucleus Tractus Solitarius in the Rat
Publikováno v:
Neuroscience. 452:326-334
Buspirone, a partial agonist of the 5-HT1aR, due to potential antinociceptive properties can be useful for abdominal pain treatment in IBS patients. Pain-related effects of buspirone can be mediated by the 5-HT1aRs, located within the nucleus tractus
Autor:
Michael P. Wiggs, Bumsoo Ahn, Stephanie E. Hall, Aaron B. Morton, Ashley J. Smuder, J. Matthew Hinkley, Scott K. Powers, Hayden W. Hyatt, Kurt J. Sollanek
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 2, Pp 481-486 (2021)
Clinical and Translational Science, Vol 14, Iss 2, Pp 481-486 (2021)
Mechanical ventilation (MV) is a life‐saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of inspiratory muscle weakness due to diaphragmatic atrophy and contractile dysfunction (termed
Autor:
Zhonglei Bao, Huixue Zhang, Yuze Cao, Xiaoyu Lu, Xiaoming Zhang, Lihua Wang, Shangwei Ning, Liying Cui, Wenqi Tian, Jianjian Wang, Shengnan Sun
Publikováno v:
Neuroscience. 444:106-117
The nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic stroke. Our previous study showed that microRNA-9a-5p (miR-9a-5p) ameli
Autor:
Wei Ling Lim, Andrea Tsz Ching Mok, Arjan Blokland, Shawn Zheng Kai Tan, Yasin Temel, Jose Angelo Udal Perucho, Ariel Yovela Chan, Luca Aquili, Lee Wei Lim
Publikováno v:
Brain Structure & Function, 225(7), 1957-1966. Springer
Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and agoraphobia in a contextual fear conditi
Autor:
Anna Blasiak, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Anna Gugula, Patryk Sambak, Ewa Błasiak, Grzegorz Hess, Agata Szlaga, Andrew L. Gundlach, Alan Kania, Mohammad Akhter Hossain
Publikováno v:
The Journal of Neuroscience
Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family
Publikováno v:
NeuroReport. 31:484-489
Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear hormone receptor family and is a ligand-modulated transcriptional factor. Pioglitazone, a PPARγ ligand of the thiazolidinedione class, exerts several pleiotropic effects i
Autor:
Li Hu, Jian Cai, Yinggang Sun, Jiaxiang Wu, Fuxue Chen, Jijiang Wang, Shutian Zhang, Kokwin Ooi, Xuehai Wu, Danian Zhu, Chunmei Xia
Publikováno v:
Neuroscience Bulletin
Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla (RVLM) have been implicated in stress-induced hypertension (SIH). Prorenin, a member of the brain renin-angiotensin system
Autor:
Bolong Liu, Xu-Hong Wei, Wenbiao Li, Fei Yang, Zhijun Lin, Minzhi Su, Honglu Ding, Juncong Xie, Xin Zhou, Xian-Guo Liu, Hailun Zhan, Xiangfu Zhou, Jialiang Chen
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Bladder-related pain symptoms in patients with bladder pain syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory deficits. Magnesium deficiency contributes to neuroinflammation and is associated with pain,