Zobrazeno 1 - 10
of 24
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Stefan F. Lichtenthaler, Paul Saftig, Tobias B. Huber, Lukas Heintz, Lisa Seipold, Lisa Schebsdat, Maja T. Lindenmeyer, Renate Lüllmann-Rauch, Sebastian Wetzel, Stephanie Zielinski, Oliver Kretz, Catherine Meyer-Schwesinger, Marlies Sachs, Wiebke Sachs, Julia Reichelt, Thorsten Wiech, Stephan A. Müller
Publikováno v:
Journal of the American Society of Nephrology 32(6), 1389-1408 (2021). doi:10.1681/ASN.2020081213
J Am Soc Nephrol
J Am Soc Nephrol
Background Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd38702448fa14059c39567c6bc8975
Autor:
Norbert Frey, Alexandra Rosskopf, Lynn Christen, Nesrin Schmiedel, Matthias Eden, Ankush Borlepawar, Derk Frank, Renate Lüllmann-Rauch, Ashraf Yusuf Rangrez
Publikováno v:
Cells, Vol 9, Iss 2390, p 2390 (2020)
Cells
Volume 9
Issue 11
Cells
Volume 9
Issue 11
Dysbindin, a schizophrenia susceptibility marker and an essential constituent of BLOC-1 (biogenesis of lysosome-related organelles complex-1), has recently been associated with cardiomyocyte hypertrophy through the activation of Myozap-RhoA-mediated
Autor:
Stijn Stroobants, Paul Saftig, Renate Lüllmann-Rauch, Claes Andersson, Rudi D'Hooge, Meike Lüdemann, Jens Fogh, Willy Morelle, Judith Blanz, Helena Reuterwall, Jean Claude Michalski
Publikováno v:
Human Molecular Genetics. 17:3437-3445
Despite the progress in the treatment of lysosomal storage disorders (LSDs) mainly by enzyme replacement therapy, only limited success was reported in targeting the appropriate lysosomal enzyme into the brain. This prevents efficient clearance of neu
Autor:
Peter Heimann, Thomas Dierks, Markus Damme, Steven U. Walkley, Tomo Sawada, Theresa Ortkras, Björn Kowalewski, Renate Lüllmann-Rauch
Publikováno v:
Human molecular genetics. 24(7)
Deficiency of arylsulfatase G (ARSG) leads to a lysosomal storage disease in mice resembling biochemical and pathological features of the mucopolysaccharidoses and particularly features of mucopolysaccharidosis type III (Sanfilippo syndrome). Here we
Publikováno v:
Virchows Archiv. 439:90-96
The inherited deficiency of arylsulfatase A (ASA) in humans causes lysosomal accumulation of sulfatides in visceral organs and in the nervous system and leads to wide-spread demyelination (metachromatic leukodystrophy, MLD). ASA-deficient mice have p
Autor:
Renate Lüllmann-Rauch, Stefan H. Geist
Publikováno v:
Annals of Anatomy - Anatomischer Anzeiger. 176:3-9
Summary The purpose of this study was to investigate the effects of two lipidosis-inducing drugs (the anorectic drug chlorphentermine and the tricyclic antidepressantimipramine) upon the estrous cycle of rats and upon the morphology of the vaginal an
Autor:
Paul Saftig, Judith Blanz, Renate Lüllmann-Rauch, Markus Damme, Jens Fogh, Stijn Stroobants, Torben Lübke, Steven U. Walkley, Rudi D'Hooge
Publikováno v:
Journal of Neuropathology and Experimental Neurology; Vol 70
α-Mannosidosis is a rare lysosomal storage disease with accumulation of undegraded mannosyl-linked oligosaccharides in cells throughout the body, most notably in the CNS. This leads to a broad spectrum of neurological manifestations, including progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afead0ac3237869ee51b551a9725d72c
https://doi.org/10.1097/nen.0b013e31820428fa
https://doi.org/10.1097/nen.0b013e31820428fa
Autor:
Renate Lüllmann-Rauch, M. Ziegenhagen
Publikováno v:
Histochemistry. 95:263-268
The purpose of the present investigation was to examine whether or not a di-cationic amphiphilic compound that is known (1) to be accumulated in lysosomes and (2) to form insoluble complexes with sulfated glycosaminoglycans (sGAG) in vitro, is able t
Publikováno v:
Archives of Toxicology. 64:291-298
The purpose of the present investigation was to establish a cell culture system suitable for demonstrating the drug-induced lysosomal storage of sulfated glycosaminoglycans (GAGs). This is a drug side-effect which was previously studied in animals tr
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t