Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yutaka Yoshikawa"'
Autor:
Susumu Hama, Takayuki Nishi, Eitaro Isono, Shoko Itakura, Yutaka Yoshikawa, Akinori Nishimoto, Satoko Suzuki, Naoko Kirimura, Hiroaki Todo, Kentaro Kogure
Publikováno v:
Cancer Science. 113(5):1779-1788
Intraperitoneal administration of anticancer nanoparticles is a rational strategy for preventing peritoneal dissemination of colon cancer due to the prolonged retention of nanoparticles in the abdominal cavity. However, instability of nanoparticles i
Publikováno v:
Biological Trace Element Research. 192:206-213
The risk of serious complication gradually increases as diabetes mellitus (DM) progresses. Thus, strategies for the prevention and delay of symptom progression are urgently needed. Previously, we synthesized zinc (Zn) complexes estimated to have a hi
Autor:
Kengo Sasaki, Naoko Ikuta, Yutaka Yoshikawa, Gerald Rimbach, Takahiro Furune, Hinako Okamoto, Keiji Terao, Nanako Nihei
Publikováno v:
BioFactors. 44:336-347
We investigated the effect of α-cyclodextrin (α-CD) on the bacterial populations of gut microbiota, production of organic acids, and short-chain fatty acids (SCFAs), and lipid metabolism in obese mice induced by feeding a high-fat diet (HFD). Male
Autor:
Shinji Motomura, Shuichi Enomoto, Masashi Ueda, Hiroyuki Yasui, Masayuki Munekane, Shinichiro Kamino, Hiromitsu Haba, Yutaka Yoshikawa
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:510-515
Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activi
Autor:
Yutaka Yoshikawa, Hiroyuki Yasui, Michiko Shintani, Yuki Naito, Shingo Kamoshida, Naemi Kajiwara
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:318-326
Zinc (Zn) is a trace element with anti-diabetes mellitus (anti-DM) effects. Zn complexes exhibit stronger insulin-like activity than Zn ions. Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) was recently reported to be a potent anti-DM candidate. We exami
Autor:
Naemi Kajiwara, Yutaka Yoshikawa, Kinuyo Matsumoto, Ayaka Okano, Daisuke Nakata, Hiroyuki Yasui, Keiji Terao, Yuki Naito, Naoko Ikuta, Hinako Okamoto
Publikováno v:
Life Sciences. 136:73-78
Aims Previous studies reported the anti-diabetic effects of α-lipoic acid (αLA) isomers: racemic-αLA, R-αLA, or S-αLA. Previously, we examined the anti-diabetic effects of αLA administered as a food additive, but were unable to demonstrate the
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2647 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2647
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2647
International Journal of Molecular Sciences
Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKAy type 2 diabetes mouse model. Recently, we demonstrated that organo-chalcogen (sulfur and selenium) Z
Autor:
Yutaka Yoshikawa, Hiroyuki Yasui
Publikováno v:
Current Topics in Medicinal Chemistry. 12:210-218
Biological trace metals such as iron, zinc, copper, and manganese are essential to life and health of humans, and the success of platinum drugs in the cancer chemotherapy has rapidly grown interest in developing inorganic pharmaceutical agents in med
Autor:
Yutaka Yoshikawa, Akihiro Tai, Hiroki Kakuta, Fuminori Ohsawa, Makoto Makishima, Hiroyuki Yasui, Shoya Yamada
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:629-633
Retinoid X receptor (RXR) agonists are reported to exhibit blood glucose-lowering action owing to peroxisome proliferator-activated receptor (PPAR)/RXR or liver X receptor (LXR)/RXR activation, but may also cause adverse effects such as blood triglyc
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:1096-1104
Zn(II) complexes are expected to be useful in the treatment of diabetes mellitus because of the hypoglycemic effect produced by its insulin-mimetic activity. Previous reports indicated that Zn(II) complexes with coordinating sulfur exhibit higher ins