Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Xiaorong Liang"'
Autor:
Yuliang Zhao, Tao Li, Guangyuan Zhang, Xiaorong Liang, Yanxia Wang, Jiansheng Kang, Jiangang Ma
Publikováno v:
European Archives of Oto-Rhino-Laryngology. 280:2435-2443
Objective Bariatric surgery (BS) is considered one of the most effective treatments for obese individuals with Obstructive Sleep Apnea (OSA). However, otolaryngologists have raised concerns about the structural alterations caused by BS on the upper r
Autor:
Ryan Johnson, Imran Rehmani, Mark Leahy, Abigail Walker, Xiaorong Liang, Brian Dean, Jianshuang Wang
Publikováno v:
Bioanalysis. 14:1377-1389
Volumetric absorption microsampling devices offer minimally invasive and user-friendly collection of capillary blood in volumes as low as 10 μl. Herein we describe the assay validation for determination of the selective estrogen receptor degrader gi
Publikováno v:
Biomedical Chromatography. 37
Microsampling technology for dried blood-derived samples provides an advantageous alternative to conventional venous blood for drug quantitation. Unlike conventional whole blood microsampling techniques, Noviplex is a novel, card-based technology for
Autor:
Zijuan Lai, Feroza K. Choudhury, Danming Tang, Xiaorong Liang, Brian Dean, Shahram Misaghi, Dewakar Sangaraju
Publikováno v:
Biomedical chromatography : BMCREFERENCES. 36(5)
Chinese hamster ovary (CHO) cells have been widely used in the biopharmaceutical industry for production of therapeutic proteins. CHO cells in fed-batch cultures produce various amino acid-derived intermediate metabolites. These small molecule metabo
Autor:
Sophie Mukadam, Jonathan Cheong, Leslie Wang, Hoa Le, Kang-Jye Chou, Xiaorong Liang, Deepak Sampath, Bianca M. Liederer, Jason Oeh, Peter S. Dragovich, Susan Wong, Justin Ly
Publikováno v:
Xenobiotica. 49:1063-1077
GNE-617 (N-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide) is a potent, selective nicotinamide phosphoribosyltransferase (NAMPT) inhibitor being explored as a potential treatment for human cancers.Plasma clearance was lo
Autor:
Sami Mahrus, Dennis Milanowski, Kari M. Morrissey, Dennis L. Miller, Brian Dean, Stephanie Cape, Drew Dorshorst, Xiaorong Liang, Janine McKnight, Lei Tan
Publikováno v:
Bioanalysis. 10:1307-1317
Aim: Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) catalyze the initial and rate-controlling step of tryptophan metabolism through the kynurenine pathway, which plays an important role in mediating immune response. Accurate m
Autor:
Michael Van Parys, Xiaorong Liang, Dennis L. Miller, Brian Dean, Yang Gao, Yao Shi, Dennis Milanowski
Publikováno v:
Bioanalysis. 10:917-932
Aim: Investigation of bile acids (BAs) as biomarkers for liver and kidney diseases has gained momentum recently to fulfill the needs in drug development and clinical practice, but a thorough and rapid profiling of BAs in human plasma has been hindere
Autor:
Roxanne Andaya, Kirsten Messick, Jacqueline M. Tarrant, Xiao Ding, Trung Nguyen, Jessica Couch, Michelle G. Schweiger, Shelly Zhong, Xiaorong Liang, Bianca M. Liederer, Brian Dean, Eric Harstad
Publikováno v:
ILAR Journal. 57:157-165
Improved small molecule bioanalytical sensitivity and concomitant decreased sample volume requirements provide an opportunity to reconsider how toxicokinetic (TK) data are collected in rat toxicity studies. Often, satellite groups of rats are designa
Publikováno v:
Bioanalysis.
Aim: The applicability of polysaccharide-based chiral stationary phases in modern supercritical fluid chromatography (SFC)–MS/MS for chiral bioanalysis was evaluated. Materials & methods: Ten popular polysaccharide-based chiral stationary phases (C
Autor:
Xiao Ding, Brian Dean, Yuzhong Deng, Michael Van Parys, Jialin Mao, Ning Zeng, Janine McKnight, Luke Bi, Yuan Chen, Joseph A. Ware, Cornelis E. C. A. Hop, Drew Dorshort, Xiaorong Liang, Dennis Milanowski
Publikováno v:
Journal of Chromatography B. 1020:111-119
A high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay was developed and validated for simultaneous determination of itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), keto-itraconazole (keto-ITZ) and N-desalkyl itraconazo