Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Wonkam, A."'
Autor:
C Day, M Deetlefs, A O’Brien, J Smith, M Boyd, N Embling, S Patel, K Moody, T Ramabele, A Budge, T Tarwa, O Jim, T Maharaj, S Pandy, J-M Abrahams, A Panieri, S Verhage, M Van der Merwe, A Geragotellis, W Amanjee, C Joseph, Z Zhao, S Moosa, M Bunting, Y Pulani, P Mukhari, M De Paiva, G Deyi, R P Wonkam, N Mancotywa, A Dunge, T Msimanga, A Singh, O Monnaruri, B Molale, T A G Butler, K Browde, C Muller, J Van der Walt, R Whitelaw, D Cronwright, S Sinha, U Binase, I Francis, D Boakye, S Dlamini, M Mendelson, J Peter
Publikováno v:
South African Medical Journal. :69-74
Background. Up to a quarter of inpatients in high-income countries (HICs) self-report beta-lactam allergy (BLA), which if incorrect,increases the use of alternative antibiotics, worsening individual health outcomes and driving bacterial resistance. I
Autor:
Kevin K Esoh, Tobias O Apinjoh, Alfred Amambua-Ngwa, Steven G Nyanjom, Emile R Chimusa, Lucas Amenga-Etego, Ambroise Wonkam, Eric A Achidi
Publikováno v:
Human Molecular Genetics.
Recent data suggest that only a small fraction of severe malaria heritability is explained by the totality of genetic markers discovered so far. The extensive genetic diversity within African populations means that significant associations are likely
Publikováno v:
Open Medicine, Vol 17, Iss 1, Pp 61-69 (2021)
Open Medicine
Open Medicine
Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted m
Publikováno v:
Annu Rev Biomed Data Sci
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which generally requires data connecting genotype to phenotype, as done in genome-wide association studies (GWAS). While there may be clinical promise to employing p
Autor:
Arthemon Nguweneza, Valentina Josiane Ngo Bitoungui, Khuthala Mnika, Gaston Mazandu, Victoria Nembaware, Andre P. Kengne, Ambroise Wonkam
Publikováno v:
Frontiers in medicine. 9
Increased blood pressure (BP) has been associated with higher risk of stroke and mortality in Sickle Cell Disease (SCD). We investigated risk factors associated with Relative Systemic Hypertension (RSH) or systemic hypertension in SCD patients in Cam
Autor:
Ambroise Wonkam, Kevin K Esoh
Publikováno v:
Human Molecular Genetics
Resistance afforded by the sickle-cell trait against severe malaria has led to high frequencies of the sickle-cell mutation [HBB; c.20T>A, p.Glu6Val; OMIM: 141900 (HBB-βS)] in most parts of Africa. High-coverage sequencing and genotype data have now
Autor:
Giorgio Sirugo, Ambroise Wonkam
Publikováno v:
Annals of Internal Medicine. 175:1187-1188
Autor:
Kevin Dzobo, Ambroise Wonkam, Chelene Ganz, Nicholas Ekow Thomford, Collet Dandara, Dimakatso Alice Senthebane
Publikováno v:
Cells, Vol 9, Iss 1896, p 1896 (2020)
Cells
Cells
Despite great strides being achieved in improving cancer patients’ outcomes through better therapies and combinatorial treatment, several hurdles still remain due to therapy resistance, cancer recurrence and metastasis. Drug resistance culminating
Autor:
Daniella Munro, Bridget Calder, Nicholas Ekow Thomford, Kevin Dzobo, Nelson C. Soares, Tina Jonker, Dhirendra Govender, Jonathan M. Blackburn, Collet Dandara, Arielle Rowe, Dimakatso Alice Senthebane, Ambroise Wonkam, M. Iqbal Parker
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 10
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2861 (2018)
Volume 19
Issue 10
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2861 (2018)
Background: The functional interplay between tumor cells and their adjacent stroma has been suggested to play crucial roles in the initiation and progression of tumors and the effectiveness of chemotherapy. The extracellular matrix (ECM), a complex n
Publikováno v:
BMJ Open
IntroductionSickle cell disease (SCD) is an inherited haematological disorder caused by a single point mutation (Glub6Val) that promotes polymerisation of haemoglobin S and sickling of erythrocytes. Inflammation, haemolysis, microvascular obstruction