Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Matthew R. Sydes"'
Autor:
Archie Macnair, Matthew Nankivell, Macey L. Murray, Stuart D. Rosen, Sally Appleyard, Matthew R. Sydes, Sylvia Forcat, Andrew Welland, Noel W. Clarke, Stephen Mangar, Howard Kynaston, Roger Kockelbergh, Abdulla Al-Hasso, John Deighan, John Marshall, Mahesh Parmar, Ruth E. Langley, Duncan C. Gilbert
Publikováno v:
Contemporary Clinical Trials. 128:107162
Autor:
Ian R White, Babak Choodari-Oskooei, Matthew R Sydes, Brennan C Kahan, Leanne McCabe, Anna Turkova, Hanif Esmail, Diana M Gibb, Deborah Ford
Publikováno v:
Clinical trials (London, England). 19(4)
Background Factorial designs and multi-arm multi-stage (MAMS) platform designs have many advantages, but the practical advantages and disadvantages of combining the two designs have not been explored. Methods We propose practical methods for a combin
Autor:
Claire L Vale, Sylvie Chabaud, Matthew R. Sydes, Andrew Kneebone, Mahesh K. B. Parmar, Paul Sargos, Carol Fraser-Browne, Chris Brown, David Fisher, Adrian Cook, Silvia Forcat, Chris Parker, Maria Pearse, Pierre Richaud, Meryem Brihoum, Christopher D. Brawley, Igor Latorzeff, Jayne F. Tierney
Publikováno v:
The Lancet. 396:1422-1431
Summary Background It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localised or locally advanced prostate cancer. We aimed to prospectively plan a systematic re
Publikováno v:
Clinical trials (London, England). 19(2)
Autor:
Nicola Joffe, Victoria Yorke-Edwards, Macey L. Murray, Carlos Diaz-Montana, Sharon Love, Lindsey Masters, Michelle Gabriel, Matthew R. Sydes
Publikováno v:
Clinical Trials (London, England)
Publikováno v:
Clinical Trials (London, England)
CLINICAL TRIALS
Lane, J A, Gamble, C, Cragg, W J, Tembo, D & Sydes, M R 2020, ' A third trial oversight committee : Functions, benefits and issues ', Clinical Trials, vol. 17, no. 1, pp. 106-112 . https://doi.org/10.1177/1740774519881619
CLINICAL TRIALS
Lane, J A, Gamble, C, Cragg, W J, Tembo, D & Sydes, M R 2020, ' A third trial oversight committee : Functions, benefits and issues ', Clinical Trials, vol. 17, no. 1, pp. 106-112 . https://doi.org/10.1177/1740774519881619
Background/aims: Clinical trial oversight is central to the safety of participants and production of robust data. The United Kingdom Medical Research Council originally set out an oversight structure comprising three committees in 1998. The first com
Autor:
Anna Hockaday, Rebecca Maier, Munyaradzi Dimairo, Philip Pallmann, Rachel Lowe, Jamie Hall, Jessica Welburn, Mark Pilling, Nina Wilson, Sarah Bowden, Sofia S. Villar, James Wason, Matthew R. Sydes, Caroline Murphy, Claire Snowdon, Laura Flight, Thomas Jaki, Christopher J. Weir, Julia Brown, Christina Yap, Helen C. Hancock, Katie Biggs
Publikováno v:
BMC Medicine
Wilson, N, Biggs, K, Bowden, S, Brown, J, Dimairo, M, Flight, L, Hall, J, Hockaday, A, Jaki, T, Lowe, R, Murphy, C, Pallmann, P, Pilling, M, Snowdon, C, Sydes, M R, Villar, S S, Weir, C J, Welburn, J, Yap, C, Maier, R, Hancock, H & Wason, J 2021, ' Costs and Staffing Resource Requirements for Adaptive Clinical Trials : Quantitative and qualitative results from the Costing Adaptive Trials Project ', BMC Medicine, vol. 19, 251 . https://doi.org/10.1186/s12916-021-02124-z
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Wilson, N, Biggs, K, Bowden, S, Brown, J, Dimairo, M, Flight, L, Hall, J, Hockaday, A, Jaki, T, Lowe, R, Murphy, C, Pallmann, P, Pilling, M, Snowdon, C, Sydes, M R, Villar, S S, Weir, C J, Welburn, J, Yap, C, Maier, R, Hancock, H & Wason, J 2021, ' Costs and Staffing Resource Requirements for Adaptive Clinical Trials : Quantitative and qualitative results from the Costing Adaptive Trials Project ', BMC Medicine, vol. 19, 251 . https://doi.org/10.1186/s12916-021-02124-z
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Background Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resources are required to conduct a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda3ef3551003264c2a72f967a20005c
Autor:
Catherine Hewitt, Ian Roberts, Michael King, Irwin Nazareth, Alan Watkins, Frank Sullivan, Derek Stewart, Nick Freemantle, Jane Daniels, Tobias Dreischulte, Brooke Jackson, Michael Donnelly, Martin Landray, Martin Gulliford, David A Harrison, Adam Streeter, Jennifer Logue, Paula Williamson, Marion Campbell, Martin C Gulliford, Jamie Soames, Dheeraj Rai, Stephanie MacNeill, Marion Bennie, Jo Rycroft-Malone, Matthew R Sydes, Andrew Farmer, Martyn Lewis, Elizabeth Williamson, Xavier Griffin, Colin McCowan, John Wilding, Jennifer Quint, Agnieszka Michael, Murali Shyamsundar, Tom Denwood, Deborah Ashby, Jacqui Nuttall, Kate Williams, Doreen Tembo, David Harrison, Andrew Morris, Fiona Lobban, Claire Snowdon, Martin Gibson, Rhoswyn Walker, Will Whiteley, Nick Mills, Juliet Tizzard, Emer Brady, Guillermo Lopez Campos, Catrin Tudur Smith, Yolanda Barbachano, Steph Garfield-Birkbeck, Will Navaie, Martin O'Kane, Jonathan Sheffield, Paula Walker, Rhoswyn R Walker, Janet Valentine, Susan Beatty, Helen Bodmer, Paul Brocklehurst, Steph Garfield‑Birkbeck, Doug Gould, Thomas Hiemstra, Anna Higgins, Julia Hippisley‑Cox, Sasha Korniak, Marion Mafham, Kathleen Meeley, Chris Newby, Martin O’Kane, Mike Robling, Jo Rycroft‑Malone, Matthew Sydes, Hwyel Williams
Publikováno v:
Sydes, M R, Barbachano, Y, Bowman, L, Denwood, T, Farmer, A, Garfield-Birkbeck, S, Gibson, M, Gulliford, M C, Harrison, D A, Hewitt, C, Logue, J, Navaie, W, Norrie, J, O'Kane, M, Quint, J K, Rycroft-Malone, J, Sheffield, J, Smeeth, L, Sullivan, F, Tizzard, J, Walker, P, Wilding, J, Williamson, P R, Landray, M, Morris, A, Walker, R R, Williams, H C & Valentine, J 2021, ' Realising the full potential of data-enabled trials in the UK: a call for action ', BMJ Open . https://doi.org/10.1136/bmjopen-2020-043906
BMJ Open, Vol 11, Iss 6 (2021)
BMJ Open
BMJ Open, Vol 11, Iss 6 (2021)
BMJ Open
Funding: The workshop was cofunded by National Institute of Health Research Health Technology Assessment Programme, Clinical Practice Research Datalink and Health Data Research UK; MRC grant MC_UU_12023/24 funded the salary of Matthew Sydes. Rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5073ebb1652383256943cfd88641cda0
https://hdl.handle.net/10023/23721
https://hdl.handle.net/10023/23721
Autor:
Nurulamin M Noor, Sharon B Love, Talia Isaacs, Richard Kaplan, Mahesh K B Parmar, Matthew R Sydes
Publikováno v:
BMJ Open. 12:e055615
BackgroundFor medical conditions with numerous interventions worthy of investigation, there are many advantages of a multi-arm multi-stage (MAMS) platform trial approach. However, there is currently limited knowledge on uptake of the MAMS design, esp
Autor:
Gerhardt Attard, Laura Murphy, Noel W Clarke, William Cross, Robert J Jones, Christopher C Parker, Silke Gillessen, Adrian Cook, Chris Brawley, Claire L Amos, Nafisah Atako, Cheryl Pugh, Michelle Buckner, Simon Chowdhury, Zafar Malik, J Martin Russell, Clare Gilson, Hannah Rush, Jo Bowen, Anna Lydon, Ian Pedley, Joe M O'Sullivan, Alison Birtle, Joanna Gale, Narayanan Srihari, Carys Thomas, Jacob Tanguay, John Wagstaff, Prantik Das, Emma Gray, Mymoona Alzoueb, Omi Parikh, Angus Robinson, Isabel Syndikus, James Wylie, Anjali Zarkar, George Thalmann, Johann S de Bono, David P Dearnaley, Malcolm D Mason, Duncan Gilbert, Ruth E Langley, Robin Millman, David Matheson, Matthew R Sydes, Louise C Brown, Mahesh K B Parmar, Nicholas D James, Elin Jones, Katherine Hyde, Hilary Glen, Sarah Needleman, Ursula McGovern, Denise Sheehan, Sangeeta Paisey, Richard Shaffer, Mark Beresford, Emilio Porfiri, David Fackrell, Ling Lee, Thiagarajan Sreenivasan, Sue Brock, Simon Brown, Amit Bahl, Mike Smith-Howell, Cathryn Woodward, Mau-Don Phan, Danish Mazhar, Krishna Narahari, Fiona Douglas, Anil Kumar, Abdel Hamid, Azman Ibrahim, Dakshinamoorthy Muthukumar, Matthew Simms, Jane Worlding, Anna Tran, Mohammed Kagzi, Carmel Pezaro, Virgil Sivoglo, Benjamin Masters, Pek Keng-Koh, Caroline Manetta, Duncan McLaren, Nishi Gupta, Stergios Boussios, Henry Taylor, John Graham, Carla Perna, Lucinda Melcher, Warren Grant, Ami Sabharwal, Uschi Hofmann, Robert Dealey, Neil McPhail, Robert Brierly, Lisa Capaldi, Norma Sidek, Peter Whelan, Peter Robson, Alison Falconer, Sarah Rudman, Sindu Vivekanandan, Vinod Mullessey, Maria Vilarino-Varela, Vincent Khoo, Karen Tipples, Mehran Afshar, Patryk Brulinski, Vijay Sangar, Clive Peedell, Ashraf Azzabi, Peter Hoskin, Viwod Mullassery, Santhanam Sundar, Yakhub Khan, Ruth Conroy, Andrew Protheroe, Judith Carser, Paul Rogers, Kathryn Tarver, Stephanie Gibbs, Mohammad Muneeb Khan, Mohan Hingorani, Simon Crabb, Manal Alameddine, Neeraj Bhalla, Robert Hughes, John Logue, Darren Leaning, Salil Vengalil, Daniel Ford, Georgina Walker, Ahmed Shaheen, Omar Khan, Andrew Chan, Imtiaz Ahmed, Serena Hilman, Ian Sayers, Ashok Nikapota, David Bloomfield, Tim Porter, Joji Joseph, Cyrill Rentsch, Ricardo Pereira Mestre, Enrico Roggero, Jörg Beyer, Markus Borner, Raeto Strebel, Dominik Berthold, Daniel Engeler, Hubert John, Razvan Popescu, Donat Durr
Publikováno v:
Attard, Gerhardt; Murphy, Laura; Clarke, Noel W; Cross, William; Jones, Robert J; Parker, Christopher C; Gillessen, Silke; Cook, Adrian; Brawley, Chris; Amos, Claire L; Atako, Nafisah; Pugh, Cheryl; Buckner, Michelle; Chowdhury, Simon; Malik, Zafar; Russell, J Martin; Gilson, Clare; Rush, Hannah; Bowen, Jo; Lydon, Anna; ... (2022). Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol. The lancet, 399(10323), pp. 447-460. Elsevier 10.1016/S0140-6736(21)02437-5
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators 2022, ' Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol ', Lancet (London, England), vol. 399, no. 10323, pp. 447-460 . https://doi.org/10.1016/S0140-6736(21)02437-5
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators 2022, ' Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol ', Lancet (London, England), vol. 399, no. 10323, pp. 447-460 . https://doi.org/10.1016/S0140-6736(21)02437-5
BACKGROUND Men with high-risk non-metastatic prostate cancer are treated with androgen-deprivation therapy (ADT) for 3 years, often combined with radiotherapy. We analysed new data from two randomised controlled phase 3 trials done in a multiarm, mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07768ca840f38b8ba6462bcfaa787f1