Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Masayoshi Takeuchi"'
Autor:
Risa Okimura, Chigusa Kikuchi, Masayoshi Takeuchi, Hinako Tanaka, Akiko Sakasai-Sakai, Takanobu Takata, Tamihide Matsunaga
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1399-1402
Nonalcoholic steatohepatitis (NASH), the aggressive form of the most common chronic liver disease nonalcoholic fatty liver disease, is characterized by inflammation and damage in the liver. Although hepatocyte injury and cell death have been identifi
Publikováno v:
Cells. 11(14)
The habitual and excessive consumption of sugar (i.e., sucrose and high-fructose corn syrup, HFCS) is associated with the onset and progression of lifestyle-related diseases (LSRD). Advanced glycation end-products (AGEs) have recently been the focus
Autor:
Jun-ichi Takino, Takamitsu Hori, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Kentaro Nagamine, Takuma Sato
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:112-117
Advanced glycation end-products (AGEs) are produced by the non-enzymatic reaction of sugars with proteins. It has been revealed that glyceraldehyde-derived toxic AGEs (TAGE) are elevated in the serum of non-alcoholic steatohepatitis (NASH) patients.
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 14
International Journal of Molecular Sciences, Vol 21, Iss 4861, p 4861 (2020)
Volume 21
Issue 14
International Journal of Molecular Sciences, Vol 21, Iss 4861, p 4861 (2020)
Hepatocyte cell death is a key process in the pathogenesis of nonalcoholic steatohepatitis (NASH). However, the factors responsible for and mechanisms underlying NASH-related cell death have not yet been elucidated in detail. We herein investigated t
Autor:
Takanobu Takata, Masayoshi Takeuchi, Akiko Sakasai-Sakai, Sho-ichi Yamagishi, Tadashi Ueda, Mikihiro Tsutsumi, Jun-ichi Takino, Hideyuki Hyogo
Publikováno v:
Medical Hypotheses. 84:490-493
Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), leads to fibrosis and potentially cirrhosis, liver failure, and hepatocellular carcinoma, and is one of the most common causes of liver dise
Autor:
Takeo Itoh, Junko Kajikuri, Chigusa Kikuchi, Tamihide Matsunaga, Eisei Hori, Masayoshi Takeuchi, Chie Nagami
Publikováno v:
Biologicalpharmaceutical bulletin. 40(11)
A complication of diabetes mellitus is the over-production of vascular superoxides, which contribute to the development of arteriosclerosis and peripheral arterial disease (PAD). Hyperglycemia induces the formation and accumulation of advanced glycat
Autor:
Kentaro Kogure, Jun-ichi Takino, Yoshito Ikeda, Yu Ebata, Susumu Hama, Masayoshi Takeuchi, Hiroyuki Tsuchiya, Goshi Shiota, Tomohiko Sakabe
Publikováno v:
International Journal for Vitamin and Nutrition Research. 83:137-141
Insulin resistance is a fundamental feature of metabolic disorders such as metabolic syndrome. The formation of advanced glycation end-products (AGEs) is increased in patients with hyperglycemia, which results in the loss of protein function. Therefo
Autor:
Atsuko Tahara, Nobuhiro Tahara, Tsutomu Imaizumi, Masayoshi Takeuchi, Kumiko Kaifu, Sho-ichi Yamagishi, Seiji Ueda, Seiya Okuda
Publikováno v:
Clinical Biochemistry. 46:300-303
Objectives Inhibition of dipeptidyl peptidase-4 (DPP-4) has been proposed as a potential therapeutic target for type 2 diabetes. Although soluble DPP-4 has been identified in human serum and could be associated with DPP-4 activity, the kinetics and r
Publikováno v:
Hormone and Metabolic Research. 45:387-390
Metformin use has been reported to decrease breast cancer incidence and mortality in diabetic patients. We have previously shown that advanced glycation end products (AGEs) and their receptor (RAGE) interaction stimulate growth and/or migration of pa
Publikováno v:
Clinical Biochemistry. 45:1404-1408
Fasting apolipoprotein B48 (apoB48) levels are associated with postprandial hyperlipidemia and carotid artery intima-media thickness (IMT), one of the markers of metabolic derangements and atherosclerosis, respectively. However, it remains unknown wh