Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David H. McDermott"'
Autor:
Abdul Rezzak Hamzeh, Hui Jing Lim, T. Andrews, Lauren J. Howson, David H. McDermott, Philip M. Murphy, Jérôme Le Nours, Matthew C. Cook, Ligong Liu, Jamie Rossjohn, Martin S. Davey, Stephen J. Turner, James McCluskey, Jeffrey Y. W. Mak, Maria L. Sandoval-Romero, Shamik Majumdar, Wael Awad, Anouk von Borstel, Hamish E G McWilliam, Samar Ojaimi, David P. Fairlie, Jose A Villadangos
Publikováno v:
Sci Immunol
The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset restricted to the antigen-presenting molecule MR1. Here, we report the discovery of a pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d528ed38c4afdc498bf2a10180500870
https://europepmc.org/articles/PMC8581949/
https://europepmc.org/articles/PMC8581949/
Autor:
Qian Liu, Alexander Yang, Kimberly Beacht, David H. McDermott, Philip M. Murphy, Erin Yim, Ji-Liang Gao, Albert Owusu-Ansah, Andrea Paun, Marie Siwicki
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome immunodeficiency is caused by autosomal dominant gain-of-function mutations in chemokine receptor CXCR4. Patient WHIM-09 was spontaneously cured by chromothriptic deletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915ecfef259b10bb90f1da53edcb04b0
https://europepmc.org/articles/PMC6975255/
https://europepmc.org/articles/PMC6975255/
Autor:
Barbara Rehermann, Susan M. Resnick, Anca M. Segall, Ben Bolduc, Blake A Ta'ala, Jason M. Brenchley, Patricia A. Pesavento, Arvind Varsani, Diana V. Pastrana, Nicole L. Welch, Philip M. Murphy, Olga Pletnikova, David H. McDermott, Yuk Ying S. Pang, Juan C. Troncoso, Jessica L. Whited, Brittany Stewart, John Doorbar, Bess M. Miller, Stephan P. Rosshart, Alberto Peretti, Gabriel J. Starrett, Matthew B. Sullivan, Siddharth R. Krishnamurthy, Michael J. Tisza, Christopher B. Buck
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Although millions of distinct virus species likely exist, only approximately 9000 are catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of circular DNA viruses in over 70 animal samples, ranging from nematodes to human
Autor:
Christopher B. Buck, Diana V. Pastrana, David H. McDermott, Susana L. Silva, Elizabeth A. Blair, Stefania Pittaluga, Philip M. Murphy, João F. Neves, Katherine R. Calvo, Elena Cho, Emily Landon, Pamela J. Gardner, Qian Liu, David Bianchi, Hugh H. Trout, Daniel Velez
WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), a primary immunodeficiency disorder involving panleukopenia, is caused by autosomal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4). Myelokathexis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f824e1840d5b49206a3465c5e443588
https://europepmc.org/articles/PMC6425947/
https://europepmc.org/articles/PMC6425947/
Autor:
Qian Liu, Ari B. Azani, Ji-Liang Gao, Alexander Yang, David H. McDermott, Albert Owusu-Ansah, Philip M. Murphy, Erin Yim, Marie Siwicki
Publikováno v:
The Journal of clinical investigation. 128(8)
For gene therapy of gain-of-function autosomal dominant diseases, either correcting or deleting the disease allele is potentially curative. To test whether there may be an advantage of one approach over the other for WHIM (warts, hypogammaglobulinemi
Autor:
Wadih M. Zein, Sergio D. Rosenzweig, H. Nida Sen, Mark Parta, Henry E. Wiley, Philip M. Murphy, David H. McDermott, Martha Marquesen, Gary A. Fahle, Michael D. Keller, Lauren E. Heusinkveld
Publikováno v:
F1000Research
A patient with WHIM syndrome immunodeficiency presented with sudden painless right eye blindness associated with advanced retinal and optic nerve damage. Toxoplasma gondii was detected by PCR in vitreous fluid but not serum. The patient was treated w
Autor:
Christopher J. O'Donnell, Peter W.F. Wilson, Dhavalkumar D. Patel, Ralph B. D'Agostino, Maya N. Merrell, Qiong Yang, Philip M. Murphy, David H. McDermott, L. Adrienne Cupples, Joan M.G. Sechler, Alan M. Fong
Publikováno v:
Journal of Clinical Investigation. 111:1241-1250
The chemokine receptor CX3CR1 is a proinflammatory leukocyte receptor specific for the chemokine fractalkine (FKN or CX3CL1). In two retrospective studies, CX3CR1 has been implicated in the pathogenesis of atherosclerotic cardiovascular disease (CVD)
Autor:
Philip M. Murphy, David H. McDermott
Publikováno v:
Springer Seminars in Immunopathology. 22:393-415
The importance of chemokines and their receptors during infection, which initially had been inferred from their ability to induce leukocyte chemotaxis in vitro, has now been firmly established by direct genetic evidence in mice. However, recent evide
Autor:
Philip M. Murphy, Peter A. Zimmerman, Susan F. Leitman, Florence Guignard, Cynthia A. Kleeberger, David H. McDermott
Publikováno v:
The Lancet. 352:866-870
Summary Background The rate of progression to AIDS varies among individuals infected with HIV-1. Factors responsible include two inherited human alleles, CCR5 ∆32 and CCR2-64I, which alter the protein-coding regions for the HIV-1 coreceptors/chemok
Publikováno v:
Gene. 133:285-290
The human FPR1 gene encodes the N -formyl peptide receptor, a G protein-coupled receptor (GPCR) that mediates the activation of mature myeloid cells by bacterial N -formyl oligopeptides. To investigate the molecular basis for myeloid-specific product