Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel S. Marsman"'
Autor:
Lara O’Keeffe, Nigel J. Walker, Catherine Mahony, Daniel S. Marsman, Nicholas H. Oberlies, Suzanne Fitzpatrick, James C. Griffiths, A. Wallace Hayes, James Edwards, Corrado L. Galli, Amy L. Roe
Publikováno v:
Toxicology Letters. 314:10-17
Botanical safety science continues to evolve as new tools for risk assessment become available alongside continual desire by consumers for "natural" botanical ingredients in consumer products. Focusing on botanical food/dietary supplements a recent i
Autor:
Stefan Gafner, Joseph T. Dever, James C. Griffiths, Cara Welch, Cynthia V. Rider, Michelle R. Embry, Constance A. Mitchell, Daniel S. Marsman
Publikováno v:
Regulatory Toxicology and Pharmacology. 128:105090
Botanical dietary supplement use is widespread and growing, therefore, ensuring the safety of botanical products is a public health priority. This commentary describes the mission and objectives of the Botanical Safety Consortium (BSC) - a public-pri
Publikováno v:
Food and Chemical Toxicology. 107:418-429
Botanicals used in dietary supplements industry can have toxicology concerns related to endpoint gaps that cannot be fully resolved by a history of use, or existence of conflicting safety data. However, traditional toxicological studies on botanicals
Autor:
Brian G. Lake, John G. DeLuca, Walter Wahli, Daniel S. Marsman, Timothy A. Pastoor, Penelope A. Fenner-Crisp, Russell C. Cattley, Jonathan Tugwood, Bernard A. Schwetz, Cliff Elcombe, Denise Robinson, James A. Popp
Publikováno v:
Regulatory Toxicology and Pharmacology. 27:47-60
The purpose of the workshop "Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?" was to provide a review of the current state of the science on the relationship between peroxisome proliferation and hepatocarcinogenesis.
Publikováno v:
Carcinogenesis. 16:77-82
Transforming growth factor alpha (TGF alpha) is a mitogenic growth factor for hepatocytes that may play a role in the development of liver cancer in rodents and humans. Epidermal growth factor receptor (EGFR) is the receptor for TGF alpha; its expres
Autor:
Daniel S. Marsman, James A. Popp
Publikováno v:
Carcinogenesis. 15:111-117
The biological potential of hepatic foci and tumors induced by peroxisome proliferators such as Wy-14,643 has been poorly characterized. In this study, male F-344 rats (n = 20/group/time point) were fed Wy-14,643 (0.1%) for 22, 37 or 52 weeks ('W-22'
Autor:
Kirstin Kosemund, Geetha N. Erasala, Harald Schlatter, Daniel S. Marsman, Edburga Krause, Jennifer L. Ochsenhirt
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 53(2)
Superabsorbent disposable baby diapers are sophisticated, well-engineered products that provide many benefits including convenience, comfort, exceptional leakage protection, improved hygiene and skin care benefits compared with cloth diapers. Safety
Publikováno v:
Carcinogenesis. 13(6)
Earlier studies indicated that the hepatocarcinogenic activity of two peroxisome proliferators (PP) Wy-14,643 and di(2-ethylhexyl)phthalate (DEHP) correlated to the degree of lipofuscin accumulation and sustained cell replication rather than the leve
Publikováno v:
Carcinogenesis. 12(3)
The carcinogenicity of the peroxisome proliferator WY-14,643 was compared in young (starting age 2 months) and old (starting age 15 months) rats. Old rats had a 5- to 7-fold higher yield of grossly visible hepatic tumors following 22 weeks of dietary
Autor:
James A. Popp, Daniel S. Marsman, Konrad E. Tomaszewski, Russell C. Cattley, Michael J. Olson, James G. Conway
Publikováno v:
Carcinogenesis. 10:513-519
Quantitative comparisons of the time course of biochemical and morphological changes induced by peroxisome proliferators resulting in low and high incidences of hepatic cancer have not been conducted previously under bioassay conditions. [4-Chloro-6-