Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Atul K. Bhan"'
Autor:
Kanakaraju Kaliannan, Shane O. Donnell, Kiera Murphy, Catherine Stanton, Chao Kang, Bin Wang, Xiang-Yong Li, Atul K. Bhan, Jing X. Kang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5332
Gastrointestinal toxicity (GIT) is a debilitating side effect of Irinotecan (CPT-11) and limits its clinical utility. Gut dysbiosis has been shown to mediate this side effect of CPT-11 by increasing gut bacterial β-glucuronidase (GUSB) activity and
Autor:
Manish Dhyani, Atul K. Bhan, Jacob R. Bledsoe, Anthony E. Samir, Raymond T. Chung, Dmitry S. Trifanov, Joseph Misdraji
Publikováno v:
Abdominal Imaging. 40:3078-3083
Amyloidosis is extremely rare, with an estimated 2225 new US cases reported annually. Signs and symptoms of the disease are subtle and imaging findings are not pathognomonic. Currently, diagnosis requires biopsy to demonstrate the deposition of amylo
Publikováno v:
New England Journal of Medicine. 369:853-863
A 6.5-month-old boy was admitted to the hospital because of thrombocytopenia. Anti-D immune globulin was administered intravenously, with improvement, but thrombocytopenia recurred, with anemia and neutropenia, and food allergies developed. Diagnosti
Publikováno v:
Scandinavian Journal of Rheumatology. 42:266-269
Tumour necrosis factor (TNF)-α secreted by macrophages and dendritic cells (DCs) plays a predominant role in arthritis. Our previous studies suggest that a small peptide, RVG-9R (29-aa peptide derived from the rabies virus glycoprotein, fused to 9R
Autor:
Yasuyo Shimomura, Kiyotaka Nagahama, Atsushi Mizoguchi, Emiko Mizoguchi, Atsushiro Ogawa, Richard S. Blumberg, Ken Sugimoto, Atul K. Bhan, Takashi Nagaishi, Katsunori Shirane, Hidetoshi Takedatsu
Publikováno v:
Journal of Clinical Investigation. 117:605-615
Granulomas represent a localized inflammatory reaction that is characteristically observed in many inflammatory conditions. However, the mechanisms of granuloma formation have not been fully defined. Herein we demonstrate, by using experimental model
Autor:
Marly I. Roche, Melanie Schirmer, Gautam Goel, Atul K. Bhan, Alykhan F. Shamji, John J. O'Shea, David Dombkowski, Thomas B. Sundberg, Stuart L. Schreiber, John D. Gagnon, Bernard Khor, Alison M. Paterson, Arlene H. Sharpe, Benjamin D. Medoff, Khoa D. Tran, Scott Mordecai, Kara L. Conway, Nicholas P. Restifo, Ramnik J. Xavier, Stanley Y. Shaw, Leslie N Aldrich, Rahul Roychoudhuri, Pauline H. Tan
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Autor:
Marton Keszei, Atul K. Bhan, Cox Terhorst, Guoxing Wang, Gongxian Liao, Boaz van Driel, Peter J. Halibozek, Michael O'Keeffe, Ninghai Wang
Publikováno v:
International immunology. 27(9)
The homophilic cell surface receptors CD150 (Slamf1) and CD352 (Slamf6) are known to modulate adaptive immune responses. Although the Th17 response was enhanced in Slamf6−/− C57BL/6 mice upon oral infection with Citrobacter rodentium, the patholo
Autor:
Atul K. Bhan, Marion G. Peters, Janet Andersen, Dodi Colquhoun, Tun Liu, Kenneth E. Sherman, Margaret James Koziel, Gregory K. Robbins, Charles van der Horst, Tom Nevin, Beverly Alston, George Harb, Paul A. Volberding, Raymond T. Chung
Publikováno v:
New England Journal of Medicine. 351:451-459
Chronic hepatitis C virus (HCV) infection is a cause of major complications in persons who are also infected with the human immunodeficiency virus (HIV). However, the treatment of HCV infection in such persons has been associated with a high rate of
Autor:
Jose Carlos Gutierrez-Ramos, Tracy Delaney, Emiko Mizoguchi, William A. Faubion, Stephen Manning, Svend Rietdijk, Atul K. Bhan, Anthony J. Coyle, Cox Terhorst, Ype P. de Jong, Ana C. Abadía-Molina, Kareem Clarke, Jane Tian
Publikováno v:
International Immunology. 16:205-213
Several autoimmune disease models depend on an imbalance in the activation of aggressor T(h)1 and CD4(+)CD25(+) regulatory T (T(reg)) cells. Here we compare the requirement for signals through the co-stimulatory molecules CD28 and inducible co-stimul
Autor:
Ype P. de Jong, Atul K. Bhan, Cox Terhorst, Emiko Mizoguchi, Frederic I. Preffer, Atsushi Mizoguchi, Hiroko Takedatsu
Publikováno v:
International Immunology. 15:97-108
Although CD4(+) T cells form a major subset of TCRalphabeta T cells, only a small number of TCRgammadelta T cells express CD4. Factors contributing to the down-regulation of CD4(+) TCRgammadelta T cells have not been identified. The CD5 molecule is e