Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Alexander M. Klibanov"'
Autor:
Tamires Cunha Almeida, Maria Betânia de Freitas Marques, Cibele Rodrigues Toledo, Mariana Campos Da Paz, Wagner da Nova Mussel, Gisele Rodrigues da Silva, Alexander M. Klibanov, Glenda Nicioli da Silva, Harley Da Silva Tavares, Armando Silva-Cunha, Fernanda Barçante Perasoli, Priscilla Oliveira Gil, Paulo Afonso Granjeiro, Juliana Texeira de Magalhães, Jéssica Ferreira Cardoso
Publikováno v:
International journal of biological macromolecules. 169
Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid (VCM-DMPEI nanoparticles/HA) were synthesized as an adjuvant for the treatment of bacterial endophthalmitis. The nanoparticles were formulated by experime
Autor:
Awanish Kumar, Alexander M. Klibanov
Publikováno v:
Springer US
The problem of gelation of concentrated protein solutions, which poses challenges for both downstream protein processing and liquid formulations of pharmaceutical proteins, is addressed herein by employing previously discovered viscosity-lowering bul
Publikováno v:
Biotechnology Letters. 33:411-416
Hydrophobic polycations previously developed by us efficiently kill E. coli and Staphylococcus aureus on contact. As visualized by electron microscopy herein, these pathogenic bacteria incur marked morphological damage from the exposure to these N-al
Publikováno v:
Biotechnology Letters. 30:475-479
Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their ne
Autor:
Erzheng Su, Alexander M. Klibanov
Publikováno v:
Springer US
Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in
Autor:
Alexander M. Klibanov, Ju-Hyun Yu
Publikováno v:
Biotechnology Letters. 28:555-558
The impact of co-lyophilizing horseradish peroxidase (HRP) with numerous amino acids and other chiral excipients on the enzyme's subsequent stereoselectivity [E(S/R)] in the sulfoxidation of thioanisole in 2-propanol was systematically investigated.
Publikováno v:
Biotechnology Letters. 26:1695-1700
Decrease in the titer of bacteriophage PRD1 (a model of animal adenoviruses) in aqueous solutions caused by the presence of systematically chemically derivatized surfaces was kinetically investigated. The greatest loss of infectivity – up to a 4-lo
Publikováno v:
Biotechnology Letters. 26:1103-1106
Long-term stability is critical in the successful development of pharmaceuticals, including macromolecular ones, such as proteins. Due to the relative instability of aqueous solutions of proteins, they are typically stores in a freeze-dried (lyophili
Publikováno v:
Biotechnology Letters. 25:1661-1665
A procedure is developed and validated for making a non-functionalized polyolefin fabric/film highly bactericidal and fungicidal which involves a free-radical grafting of maleic anhydride, followed by an attachment of polyethylenimine (PEI) and its s
Publikováno v:
Biotechnology Letters. 24:801-805
The surface of polyethylene slides nanocoated with silica and derivatized with long-chain poly(vinyl-N-hexylpyridinium) becomes permanently bactericidal: it kills 90–99% of (both airborne and waterborne) wild-type and antibiotic-resistant strains o