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pro vyhledávání: '"Yuko Shirakuni"'
Autor:
Rika Nishikiori, Tatsuya Takagi, Yuko Shirakuni, Ryo Shimizu, Kousuke Okamoto, Masaya Kawase, Takanori Ohgaru
Publikováno v:
Journal of Chemical Information and Modeling. 48:207-212
Comparative Molecular Field Analysis (CoMFA) is most widely used as one of the 3-dimensional QSAR (3D-QSAR) methods to identify the relationship between chemical structure and biological activity. Conventional CoMFA requires at least 3 orders of expe
Autor:
Tatsuya Takagi, Takanori Ohgaru, Ryo Shimizu, Masaya Kawase, Kousuke Okamoto, Norihito Kawashita, Yuko Shirakuni, Rika Nishikiori
Publikováno v:
Journal of chemical information and modeling. 48(4)
Conventional comparative molecular field analysis (CoMFA) requires at least 3 orders of experimental data, such as IC 50 and K i, to obtain a good model, although practically there are many screening assays where biological activity is measured only