Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elisa Araldi"'
Autor:
Giovanna Grigolon, Elisa Araldi, Reto Erni, Jia Yee Wu, Carolin Thomas, Marco La Fortezza, Beate Laube, Doris Pöhlmann, Markus Stoffel, Kim Zarse, Erick M. Carreira, Michael Ristow, Fabian Fischer
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Nature Communications, 13 (1)
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Nature Communications, 13 (1)
Aging is impacted by interventions across species, often converging on metabolic pathways. Transcription factors regulate longevity yet approaches for their pharmacological modulation to exert geroprotection remain sparse. We show that increased expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84215f3cd2a1e9b77b493998631df85b
Autor:
Leigh Goedeke, Miguel A. Lasunción, Alberto Canfrán-Duque, Norma N. Anderson, Noemi Rotllan, Anders M. Näär, Alexandre Wagschal, Jay D. Horton, Elisa Araldi, Juan F. Aranda, Yajaira Suárez, Cristina M. Ramírez, Carlos Fernández-Hernando, Rafael de Cabo, Chin Sheng Lin
Publikováno v:
Nature Medicine. 21:1280-1289
The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well characterized, the post-transcriptional mechanisms that govern LDLR expr
Autor:
Abhishek Singh, Carlos Fernández-Hernando, Nathan L. Price, Gerald I. Shulman, Leigh Goedeke, Rafael de Cabo, Alberto Diaz-Ruiz, Allison Wing, Noemi Rotllan, Yajaira Suárez, Ángel Baldán, Matthew S. Rodeheffer, Elisa Araldi, Joao Paulo Camporez, Alberto Canfrán-Duque
Publikováno v:
Cell reports
Cell Reports, Vol 22, Iss 8, Pp 2133-2145 (2018)
Cell Reports, Vol 22, Iss 8, Pp 2133-2145 (2018)
SUMMARY While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovasc
Autor:
Shun He, Carlos Fernández-Hernando, José Luis Martín-Ventura, Cristina M. Ramírez, Filip K. Swirski, Nikhil Warrier, Benjamin G. Chousterman, Elisa Araldi, Binod Aryal, Yajaira Suárez, Amarylis C. B. A. Wanschel, Noemi Rotllan, Julio Madrigal-Matute, Ashley M. Fenn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature Communications
Nature Communications
Lipid accumulation in macrophages has profound effects on macrophage gene expression and contributes to the development of atherosclerosis. Here, we report that angiopoietin-like protein 4 (ANGPTL4) is the most highly upregulated gene in foamy macrop
Autor:
Erinn B. Rankin, Elisa Araldi, Amato J. Giaccia, Tremika L.S. Wilson, Jenny Yuan, Colleen Wu, Andrew L. Rankin, Ernestina Schipani, Rebecca E. Andersen, Richa Khatri, Calvin J. Kuo
Publikováno v:
Cell. 149(1):63-74
Summary Osteoblasts are an important component of the hematopoietic microenvironment in bone. However, the mechanisms by which osteoblasts control hematopoiesis remain unknown. We show that augmented HIF signaling in osteoprogenitors results in HSC n
Autor:
Julio Madrigal-Matute, Dianqing Wu, Wenwen Tang, Carlos Fernández-Hernando, Alberto Canfrán-Duque, Yajaira Suárez, Gary W. Cline, Jordan S. Pober, Miguel A. Lasunción, Elisa Araldi, Marta Fernández-Fuertes
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2743-2755 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Summary Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosy