Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Duncan T. Odom"'
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1319-1328.e6 (2020)
Cell Reports
Cell Reports
Summary Transcription factor binding to enhancer and promoter regions critical for homeostatic adult gene activation is established during development. To understand how cell-specific gene expression patterns are generated, we study the developmental
Autor:
Rozbeh Jafari, Anders Castor, Henrik Lilljebjörn, Duncan T. Odom, Mattias Vesterlund, Linda Olsson, Minjun Yang, Kajsa Paulsson, Naveen Ravi, Ioannis Siavelis, Eleanor L. Woodward, Janne Lehtiö, Louise Harewood, Larissa H. Moura-Castro, Thoas Fioretos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-24 (2020)
BMC Biology
BMC Biology
Background The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and functional impact of evolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27e3bca8e18f87ff59c5674dc5072b
https://www.repository.cam.ac.uk/handle/1810/328433
https://www.repository.cam.ac.uk/handle/1810/328433
Autor:
Jennifer Harrow, Duncan T. Odom, David Thybert, Paul Flicek, Thomas M. Keane, Adam Frankish, Ian T. Fiddes, Cristina Sisu, Mark Gerstein, Paul R. Muir, Tim Hubbard, Mark Diekhans
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pseudogenes are ideal markers of genome remodelling. In turn, the mouse is an ideal platform for studying them, particularly with the recent availability of strain-sequencing and transcriptional data. Here, combining both manual curation and automati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739d95c716655e85047b774f5f80af46
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Transposable elements (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been linked to species-specific genome innovations by rewiring regulatory circuitries. However, organisms need to restrict TE activity to
Autor:
Fanni Gergely, Jasmin Mangei, John C. Marioni, Patrice Mascalchi, Chris Bakal, Duncan T. Odom, Christina Ernst, Alexis R. Barr, Aisling M. Redmond, Vicky Bousgouni, Lovorka Stojic, Aaron T. L. Lun
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, w
Autor:
Amos Tanay, Suzana Hadjur, Duncan T. Odom, Christopher Barrington, Stephen Henderson, Christina Ernst, Matteo Vietri Rudan
Publikováno v:
Cell Reports
Cell Reports, Vol 10, Iss 8, Pp 1297-1309 (2015)
Cell Reports, Vol 10, Iss 8, Pp 1297-1309 (2015)
Summary Topological domains are key architectural building blocks of chromosomes, but their functional importance and evolutionary dynamics are not well defined. We performed comparative high-throughput chromosome conformation capture (Hi-C) in four
Autor:
Diego Villar, Duncan T. Odom
Publikováno v:
Cell. 167(3)
The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. We identified snake-specific sequence
Autor:
Paul Flicek, Ian Streeter, Alvis Brazma, David J. Adams, Jelena Aleksic, Klara Stefflova, Duncan T. Odom, Iannis Talianidis, David Thybert, Panagiota Karagianni, John C. Marioni, Michael D. Wilson
Publikováno v:
Cell
Summary To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding of three tissue-specific TFs that control liver gene expre
Autor:
Abdulrahim A. Sajini, Duncan T. Odom, Sandra Blanco, Sabine Dietmann, Shobbir Hussain, Yoichiro Sugimoto, Maike Paramor, Patrick Lombard, Michaela Frye, Joseph G. Gleeson, Jernej Ule
Publikováno v:
Cell Reports
Cell Reports, Vol 4, Iss 2, Pp 255-261 (2013)
Cell Reports, Vol 4, Iss 2, Pp 255-261 (2013)
Summary Autosomal-recessive loss of the NSUN2 gene has been identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNAs), yet the identification of cyto