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pro vyhledávání: '"Lonnie D. Shea"'
Hydrogels provide a regenerative medicine platform with their ability to create an environment that supports transplanted or endogenous infiltrating cells and enables these cells to restore or replace the function of tissues lost to disease or trauma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f9ad1829987666b1dcbd3fc3f294ed
https://europepmc.org/articles/PMC6127639/
https://europepmc.org/articles/PMC6127639/
Autor:
Aline M. Thomas, Lonnie D. Shea
Publikováno v:
Journal of Controlled Release. 170:421-429
Gene delivering biomaterials have increasingly been employed to modulate the cellular microenvironment to promote tissue regeneration, yet low transduction efficiency has been a persistent challenge for in vivo applications. In this report, we invest
Publikováno v:
Expert Opinion on Drug Delivery. 10:499-509
Gene delivery from hydrogel biomaterials provides a fundamental tool for a variety of clinical applications including regenerative medicine, gene therapy for inherited disorders and drug delivery. The high water content and mild gelation conditions o
Gene delivery to overcome astrocyte inhibition of axonal growth: An in vitro Model of the glial scar
Publikováno v:
Biotechnology and Bioengineering. 110:947-957
After injury to the central nervous system, a glial scar develops that physically and biochemically inhibits axon growth. In the scar, activated astrocytes secrete inhibitory extracellular matrix, of which chondroitin sulfate proteoglycans (CSPGs) ar
Publikováno v:
Journal of Controlled Release. 157:80-85
Gene delivery from hydrogels represents a versatile approach for localized expression of tissue inductive factors than can promote cellular processes that lead to regeneration. Lentiviral gene therapy vectors were entrapped within fibrin hydrogels, e
Publikováno v:
BioTechniques. 51:239-254
Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine. These materials are being designed to create environments that promote regeneration through a combination of: (i) scaffold architecture, (ii) the use of scaffo
Publikováno v:
Molecular Therapy. 19:1407-1415
Integrating viral gene delivery with engineered biomaterials is a promising strategy to overcome a number of challenges associated with virus-mediated gene delivery, including inefficient delivery to specific cell types, limited tropism, spread of ve
Publikováno v:
Journal of Controlled Release. 146:128-135
In regenerative medicine, hydrogels are employed to fill defects and support the infiltration of cells that can ultimately regenerate tissue. Gene delivery within hydrogels targeting infiltrating cells has the potential to promote tissue formation, b
Publikováno v:
Gene therapy
Biomaterial scaffolds that serve as vehicles for gene delivery to promote expression of inductive factors have numerous regenerative medicine applications. In this report, we investigate plasmid delivery from biomaterial scaffolds using a surface imm
Publikováno v:
Biotechnology and Bioengineering. 102:1679-1691
Non-viral gene delivery by immobilization of complexes to cell-adhesive biomaterials, a process termed substrate-mediated delivery, has many in vitro research applications such as transfected cell arrays or models of tissue growth. In this report, we