Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Raymond S. Yeung, Ralf Wienecke, Jeffrey E. DeClue, Michael J. Flaig, Ingrid Fackler, Adelheid Rust, Christian A. Sander, Matthias Volkenandt, Phuong-Anh Nguyen-Vu
Publikováno v:
Journal of Cutaneous Pathology. 28:470-475
Background: Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder associated with an alteration of the TSC2 tumor suppressor gene which encodes for the protein product tuberin. The disease is characterized by the development
Publikováno v:
Proceedings of the National Academy of Sciences. 88:9914-9918
The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimula
Autor:
Jeffrey E. DeClue, D R Lowy, Ke Zhang, R. A. Blanchard, P. Martin, Alex G. Papageorge, J. C. Stone
Publikováno v:
Molecular and Cellular Biology. 11:3132-3138
A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (
Autor:
A T Look, M B Valentine, Douglas R. Lowy, Berthe M. Willumsen, H. Cen, Jeffrey E. DeClue, Ke Zhang, Alex G. Papageorge, William C. Vass, M. R. Johnson
Publikováno v:
Ciba Foundation Symposium 176-The GTPase Superfamily
We are studying the biological activity and regulation of mammalian Ras protein in tumours and in physiological signalling. We have shown that GAP (the GTPase-activating protein) is a potent negative regulator of normal Ras in cells. Reduction or los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47c0c2231f02e237c275e3c2260b9b2
https://doi.org/10.1002/9780470514450.ch5
https://doi.org/10.1002/9780470514450.ch5
Autor:
Shaowei Li, Giovanna Benvenuto, Richard Braverman, Jeremy Peter Cheadle, Ralf Wienecke, Jeffrey E. DeClue, William C. Vass, Samantha J. Brown, Julian R. Sampson, Dicky J. J. Halley
Publikováno v:
Oncogene, 19, 6306-6316. Nature Publishing Group
We report here that overexpression of the tuberous sclerosis-1 (TSC1) gene product hamartin results in the inhibition of growth, as well as changes in cell morphology. Growth inhibition was associated with an increase in the endogenous level of the p
Publikováno v:
Genetical research. 74(2)
The murine t complex on chromosome 17 contains a number of homozygous lethal and semi-lethal mutations that disrupt development of the mouse embryo. We recently characterized an embryonic lethality in the rat that results from a germ-line mutation in