Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jaekwang Jeong"'
Autor:
Joshua VanHouten, Wonnam Kim, Peter A. Friedman, W. Bruce Sneddon, Pamela Dann, John J. Wysolmerski, Jaekwang Jeong, Catherine Sullivan, Jungmin Choi
Publikováno v:
Journal of Biological Chemistry. 292:6555-6568
We examined whether the scaffolding protein sodium-hydrogen exchanger regulatory factor 1 (NHERF1) interacts with the calcium pump PMCA2 and the tyrosine kinase receptor ErbB2/HER2 in normal mammary epithelial cells and breast cancer cells. NHERF1 in
Autor:
Peter A. Friedman, Herbert Yu, Virginia Espina, Lance A. Liotta, David F. Stern, Pamela Dann, Catherine A.W. Sullivan, Joshua VanHouten, John J. Wysolmerski, Jaekwang Jeong, Wonnam Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(3)
In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174849 (2017)
PLoS ONE
PLoS ONE
ErbB2/HER2/Neu is a receptor tyrosine kinase that is overexpressed in 25-30% of human breast cancers, usually associated with amplification of the ERBB2 gene. HER2 has no recognized ligands and heterodimers between HER2 and EGFR (ErbB1/HER1) or HER2