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pro vyhledávání: '"Haigang Ren"'
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). DJ-1 acts essential roles in neuronal protect
Publikováno v:
Experimental and Therapeutic Medicine
Circadian rhythm serves an essential role in numerous physiological functions. Circadian oscillations are organized by circadian clock components at the molecular level. The precision of the circadian clock is controlled by transcriptional-translatio
Publikováno v:
Neuroscience bulletin. 34(6)
Autophagy is an evolutionarily-conserved self-degradative process that maintains cellular homeostasis by eliminating protein aggregates and damaged organelles. Recently, vesicle-associated membrane protein-associated protein B (VAPB), which is associ
Autor:
Haigang Ren, Jiayuan Wu, Meiling Sun, Qin Xia, Mei Li, Zhouteng Tao, Qingsong Hu, Lijuan Cao, Guanghui Wang, Zheng-Hong Qin, Dong Chen
Publikováno v:
Acta Pharmacologica Sinica. 36:1043-1052
In the penumbra after focal cerebral ischemia, an increase of protease Omi is linked to a decrease of Hs1-associated protein X-1 (Hax-1), a protein belonging to the Bcl-2 family. In this study we investigated the mechanisms underlying the regulation
Autor:
Qingsong Hu, Chen Fu, Dong Chen, Ranjie Xu, Zheng Ying, Liang Zhou, Haigang Ren, Feng Gao, Hongfeng Wang, Guanghui Wang
Publikováno v:
Acta Pharmacologica Sinica
Aim: To investigate whether sequestosome 1/p62 (p62), a key cargo adaptor protein involved in both the ubiquitin-proteasome system and the autophagy-lysosome system, could directly regulate autophagy in vitro. Methods: HEK 293 cells or HeLa cells wer
Publikováno v:
Molecular Psychiatry. 16:1105-1116
Genetic variations in the DTNBP1 gene (encoding the protein dysbindin-1) have been implicated as risk factors in the pathogenesis of schizophrenia. Previous studies have indicated that dysbindin-1 functions in the regulation of synaptic activity. Rec
Publikováno v:
Journal of Biological Chemistry. 283:4022-4030
DJ-1, originally identified as an oncogene product, is a protein with various functions in cellular transformation, oxidative stress response, and transcriptional regulation. Although previous studies suggest that DJ-1 is cytoprotective, the mechanis
Publikováno v:
Neuroscience bulletin. 31(4)
Autophagy is a major degradation system which processes substrates through the steps of autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. Aberrant autophagic flux is present in many pathological conditions including n
Autor:
Guanghui Wang, Hongfeng Wang, Bin Li, Longping Wen, Na Man, Nobuyuki Nukina, Haigang Ren, Qingsong Hu, E Fei
Publikováno v:
Cell death and differentiation. 17(11)
Omi, also known as high temperature requirement factor A2 (HtrA2), is a serine protease that was originally identified as a proapoptotic protein. Like Smac/Diablo, it antagonizes inhibitor of apoptosis proteins when released into the cytosol on apopt
Publikováno v:
Molecular cancer research : MCR. 7(8)
Nurr1 is a member of the NGFI-B nuclear orphan receptor family which includes two other members, Nur77 and Nor-1. Nurr1 is essential for the development and survival of dopaminergic neurons. It was reported that Nurr1 has antiapoptotic functions, how