Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mauricio J. Reginato"'
Autor:
Joyce V. Lee, Mircea Ivan, Valerie L. Sodi, Dimpi Mukhopadhyay, Zachary A. Bacigalupa, Mauricio J. Reginato, Kathryn E. Wellen, Wiktoria A. Gocal, Christina M. Ferrer
Publikováno v:
Oncogene
Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that
Autor:
Pavel Dráber, Christos D. Katsetos, Agustin Legido, Jack A. Tuszyn´ski, Mauricio J. Reginato, Eduarda Dráberová, Peter W. Baas, Luca D'Agostino
Publikováno v:
Seminars in Pediatric Neurology. 22:49-72
Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Curren
Publikováno v:
Oncotarget
ERBB2/HER2 belongs to the EGFR-family of receptor tyrosine kinases and its overexpression can promote tumor progression. Breast cancer patients with ERBB2 amplifications are currently treated with lapatinib, a small-molecule kinase inhibitor that spe
Autor:
Ramana V. Davuluri, Maitri Y. Shah, C. Devlin, M. P. Voorhoeve, Xue Wu, Jana Ferdin, M. S. Nicoloso, George A. Calin, Mircea Ivan, Mauricio J. Reginato, Krishan Kumar, Maria Angelica Cortez, Bogdan Czerniak, Naohiro Nishida, Da Yang, Tanja Kunej, Thomas D. Schmittgen, Wei Zhang, Hui Ling, Massimo Negrini, Y. Bi, Manuela Ferracin, Masayoshi Shimizu
Publikováno v:
Cell Death & Differentiation
Recent data have linked hypoxia, a classic feature of the tumor microenvironment, to the function of specific microRNAs (miRNAs); however, whether hypoxia affects other types of noncoding transcripts is currently unknown. Starting from a genome-wide
Autor:
Maximillian Reichert, Anil K. Rustgi, Gregory P. Botta, Mauricio J. Reginato, Peter I. Lelkes
Publikováno v:
Molecular Cancer Research. 10:183-196
Pancreatic ductal adenocarcinomas (PDAC) are highly invasive and metastatic neoplasms commonly unresponsive to current drug therapy. Overwhelmingly, PDAC harbors early constitutive, oncogenic mutations in K - Ras G12D that exist prior to invasion. Hi
Autor:
S. RaElle Jackson, Andres J. Klein-Szanto, Kelly A. Whelan, Mauricio J. Reginato, Kristina S. Shahriari, Sarah A. Caldwell, Keneshia K. Haenssen
Publikováno v:
Journal of Cell Science. 123:1373-1382
ErbB2, a receptor tyrosine kinase highly expressed in many tumors, is known to inhibit apoptotic signals. Overexpression of ErbB2 causes anoikis resistance that contributes to luminal filling in three-dimensional mammary epithelial acinar structures
Autor:
Thomas P. Lynch, Christina M. Ferrer, Kristina S. Shahriari, S. RaElle Jackson, Keith Vosseller, Mauricio J. Reginato
Cancer cells universally increase glucose and glutamine consumption, leading to the altered metabolic state known as the Warburg effect; one metabolic pathway, highly dependent on glucose and glutamine, is the hexosamine biosynthetic pathway. Increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c9c305f9ea3f2cc775ecf489050d98
https://europepmc.org/articles/PMC3322861/
https://europepmc.org/articles/PMC3322861/
Autor:
Thomas P. Lynch, Geetika Sethi, S R Jackson, Kristina S. Shahriari, Mauricio J. Reginato, Sarah A. Caldwell, Sarah R. Walker, Keith Vosseller
Publikováno v:
Oncogene. 29(19)
Cancer cells upregulate glycolysis, increasing glucose uptake to meet energy needs. A small fraction of a cell's glucose enters the hexosamine biosynthetic pathway (HBP), which regulates levels of O-linked beta-N-acetylglucosamine (O-GlcNAc), a carbo
Autor:
Peter I. Lelkes, S. Heeg, Mauricio J. Reginato, Anil K. Rustgi, Gregory P. Botta, Maximilian Reichert
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 359-372 (2013)
Pancreatic ductal adenocarcinoma (PDAC) commonly contains a mutation in K-Ras(G12D) and is characterized by a desmoplastic reaction composed of deregulated, proliferating cells embedded in an abnormal extracellular matrix (ECM). Our previous observat