Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Kathy Q. Cai, Kerry S. Campbell, Tiffany Luong, Tatiana Pazina, Wafik S. El-Deiry, Allison N. Lau, Ruchi Malik, Débora Barbosa Vendramini-Costa, Harvey Hensley, Alexander Muir, Dustin Rollins, Ralph Francescone, Yan Zhou, Siddharth Balachandran, Edna Cukierman, Sapna Gupta, Karthik Devarajan, Warren D. Kruger, Huamin Wang, Roshan J. Thapa, Matthew G. Vander Heiden, Jessica Wagner, Yinfei Tan, Diana Restifo, Andres J. Klein-Szanto, Suraj Peri, Igor Astsaturov, Linara Gabitova, Janusz Franco-Barraza
Publikováno v:
PMC
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multiplex data from patient tissue, three-dimensional coculturing in vit
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Autor:
Priya Chatterji, Uma M. Sachdeva, Helen Remotti, Rei Mizuno, Kensuke Suzuki, Anil K. Rustgi, Michael P. Verzi, Sepideh Besharati, Yasunori Masuike, Wenping Sun, Sarah F. Andres, Andres J. Klein-Szanto
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Autor:
Kwok-K Wong, Maureen E. Murphy, Jason R. Pitarresi, Mirazul Islam, Gizem Efe, Tatiana A. Karakasheva, Jianhua Hu, Andres J. Klein-Szanto, Jinyang Li, Taiji Yamazoe, Ben Z. Stanger, Zhenyi Su, Maoting Chen, Adam J. Bass, Wei Gu, Anil K. Rustgi, Jessica C. Leung, Anna M. Chiarella, Shoji Natsugoe, Hiroshi Nakagawa, Samuel Pan, Qiaosi Tang, J. Alan Diehl
Publikováno v:
Genes Dev
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. P53R175H (homologous to Trp53R172H in mice) is a common hot spot mutation. How metastasis is regulated by p53R175H in ESCC rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33807ec0bf0ee5cfec8bcbefa93fc57e
https://europepmc.org/articles/PMC8015716/
https://europepmc.org/articles/PMC8015716/
Autor:
Timothy Ito, Andres J. Klein-Szanto, Jinfei Xu, Joseph R. Testa, David L. Wiest, Suraj Peri, Eleonora Sementino, Zemin Liu, Yinfei Tan, Kathy Q. Cai, Jianming Pei
Publikováno v:
Oncotarget
// Yinfei Tan 1, * , Eleonora Sementino 1, * , Jinfei Xu 1 , Jianming Pei 1 , Zemin Liu 1 , Timothy K. Ito 1 , Kathy Q. Cai 2 , Suraj Peri 3 , Andres J.P. Klein-Szanto 1, 2 , David L. Wiest 4 , Joseph R. Testa 1 1 Cancer Biology Program, Fox Chase Ca
Autor:
Ashley A. Lento, Hiroshi Nakagawa, Kensuke Suzuki, Qiaosi Tang, Mirazul Islam, Adam J. Bass, Anil K. Rustgi, Veronique Giroux, Gizem Efe, Apple Long, E. Paul Wileyto, Tatiana A. Karakasheva, Andres J. Klein-Szanto
Publikováno v:
EMBO Rep
Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer worldwide. The most commonly mutated gene in ESCC is TP53. Using a combinatorial genetic and carcinogenic approach, we generate a novel mouse model of ESCC expr
Autor:
Anna-Mariya, Kukuyan, Eleonora, Sementino, Yuwaraj, Kadariya, Craig W, Menges, Mitchell, Cheung, Yinfei, Tan, Kathy Q, Cai, Michael J, Slifker, Suraj, Peri, Andres J, Klein-Szanto, Frank J, Rauscher, Joseph R, Testa
Publikováno v:
Cancer research. 79(16)
Pleural malignant mesothelioma (MM) is a therapy-resistant cancer affecting the serosal lining of the thoracic cavity. Mutations/deletions of BAP1, CDKN2A, and NF2 are the most frequent genetic lesions in human MM. We introduced various combinations
Autor:
Jeffrey J Headd, Kathy N. Williams, Jacqueline B Plesset, Ashley A. Lento, Rosemarie Mick, Andres J. Klein-Szanto, Priya Chatterji, Rei Mizuno, Anil K. Rustgi, Sarah F. Andres, Kathryn E. Hamilton
Publikováno v:
Carcinogenesis
The RNA-binding protein insulin-like growth factor 2 mRNA binding protein 1 (IMP1) is overexpressed in colorectal cancer (CRC); however, evidence for a direct role for IMP1 in CRC metastasis is lacking. IMP1 is regulated by let-7 microRNA, which bind
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma
Autor:
Carsten Weishaupt, Björn Kemper, Agatha Stegemann, Mauro Picardo, Andres J. Klein-Szanto, Arianna Mastrofrancesco, Markus Böhm, Dieter Metze
Publikováno v:
Acta Dermato Venereologica. 100:adv00157
Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing prefo
Autor:
Kathleen Schuck, N. Volkan Adsay, Anil K. Rustgi, Albert B. Reynolds, Lauren Simon, Karin Feldmann, Dieter Saur, Wilko Weichert, Matthias Wirth, Anna Melissa Schlitter, Basil Bakir, Burcin Pehlivanoglu, Andres J. Klein-Szanto, Andrew D. Rhim, Leticia Moreira, Günter Schneider, Bahar Memis, Maximilian Reichert, Kensuke Suzuki, Ravikanth Maddipati, Jason R. Pitarresi, Mark Kriegsmann
Publikováno v:
Developmental Cell
Summary The regulation of metastatic organotropism in pancreatic ductal a denocarcinoma (PDAC) remains poorly understood. We demonstrate, using multiple mouse models, that liver and lung metastatic organotropism is dependent upon p120catenin ( p120ct