Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Ryan C. Gimple, Guoxin Zhang, Linjie Zhao, Leo J.Y. Kim, Jia Z. Shen, Cheryl Kim, Briana C. Prager, Xujun Wang, Jean A. Bernatchez, Xiang-Dong Fu, Jeremy N. Rich, Kailin Yang, Jair L. Siqueira-Neto, Deobrat Dixit, Zhixin Qiu, Lukas Chavez, Zhe Zhu, Deguan Lv, Ye Zheng, Denise Hinz, Zhengyu Liang, Charles Spruck, Xiuxing Wang, Chunyu Jin, Qiyuan Yang, Qiulian Wu, Lihua Min, Katherine A. Jones, Zhen Dong, Shruti Bhargava
Publikováno v:
Cancer Discov
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSC). Here, we interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-de
Autor:
Stephen C. Mack, Leo J.Y. Kim, Hu Cang, Zhen Dong, Deguan Lv, Jeremy N. Rich, Megan E Wolf, Reilly L. Kidwell, Qi Xie, Tao Huan, Qing Ye, J. Mark Brown, Xiuxing Wang, Tengqian Sun, Junfeng Bi, Guoxin Zhang, Derrick Lee, Ryan C. Gimple, Andrew E. Sloan, Zhe Zhu, Shruti Bhargava, Anthony D. Gromovsky, Linjie Zhao, Briana C. Prager, Li Jiang, Qiulian Wu, Paul S. Mischel
Publikováno v:
Cancer Discovery. 9:1248-1267
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSC) contribute to this poor prognosis by driving therapeutic resistance and maintaining cellular heterogeneity. To understand the m
Autor:
Briana C. Prager, Kristopher Berrett, Jeremy N. Rich, Michael N. Wilkinson, Joshua B. Rubin, Sumithra Sankararaman, Lauren Broestl, Xuhua Chen, Robi D. Mitra, Zongtai Qi, Najla Kfoury, Jason Gertz, Arnav Moudgil
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Consistent sex differences in incidence and outcome have been reported in numerous cancers including brain tumors. GBM, the most common and aggressive primary brain tumor, occurs with higher incidence and shorter survival in males compar
Autor:
Thomas H. Keller, Heide L. Ford, Guoxin Zhang, Lingdi Zhang, Leo J.Y. Kim, Lisa M Wood, Ryan L Anderson, Jia Z. Shen, Grace Lin, Li Jiang, Zhen Dong, Qiulian Wu, Xiuxing Wang, Petra Hamerlik, Arthur Wolin, Ryan C. Gimple, Zhixin Qiu, CongBao Kang, Shideng Bao, Jeremy N. Rich, Deguan Lv, Linjie Zhao, Jeffrey K. Moore, Rui Zhao, Briana C. Prager
Publikováno v:
Zhang, G, Dong, Z, Gimple, R, Wolin, A, Wu, Q, Qiu, Z, Wood, L, Shen, J, Jiang, L, Zhao, L, Lv, D, Prager, B C, Kim, L J Y, Wang, X, Zhang, L, Anderson, R L, Moore, J K, Bao, S, Keller, T H, Lin, G, Kang, C, Hamerlik, P, Zhao, R, Ford, H L & Rich, J N 2021, ' Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe ', Journal of Experimental Medicine, vol. 218, no. 11, e20202669 . https://doi.org/10.1084/jem.20202669
Glioblastoma ranks among the most lethal of primary brain malignancies, with glioblastoma stem cells (GSCs) at the apex of tumor cellular hierarchies. Here, to discover novel therapeutic GSC targets, we interrogated gene expression profiles from GSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45edb88141fa3497ff826b487577c767
https://curis.ku.dk/ws/files/285939506/jem_20202669_1_.pdf
https://curis.ku.dk/ws/files/285939506/jem_20202669_1_.pdf
Autor:
Xiuxing Wang, Guoxin Zhang, Leo J.K. Kim, Petra Hamerlik, Briana C. Prager, Ryan C. Gimple, Zhen Dong, Jeremy N. Rich, Shideng Bao, Qiulian Wu
Publikováno v:
JCI Insight. 4
Glioblastomas, which contain stem cell-like glioblastoma stem cells (GSCs), are universally lethal cancers. While neural stem cells (NSCs) are usually quiescent, single-cell studies suggest that proliferating glioblastoma cells reside in the GSC popu
Autor:
Guoxin Zhang, Haidong Huang, Ryan C. Gimple, Zhixin Qiu, Stephen C. Mack, Shideng Bao, Zhen Dong, Leo J.Y. Kim, Lukas Chavez, Deobrat Dixit, Bin Li, Briana C. Prager, Andrew R. Morton, Xiuxing Wang, Zhe Zhu, Meng Qu, Steve A. Kay, Jeremy N. Rich, Wenchao Zhou, Qiulian Wu
Publikováno v:
Cancer Discov
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant brain cultures all displayed robust circadian rhythms, yet GSCs alone
Autor:
Xiuxing Wang, Wenchao Zhou, Lukas Chavez, Shideng Bao, Andrew E Sloan, Michael A. Vogelbaum, Jean A. Bernatchez, Kelsey C. Bertrand, Peter C. Scacheri, Q Wu, Irtisha Singh, Clarence K. Mah, Stephen C. Mack, Jair L. Siqueira-Neto, Zhixin Qiu, Andrew R. Morton, Rosie Villagomez, Sisi Lai, Gene H. Barnett, Christine Lee, Rachel A. Hirsch, Briana C. Prager, Jeremy N. Rich, Zhe Zhu, Ryan C. Gimple, Charles Y. Lin, Leo J.Y. Kim
Publikováno v:
The Journal of Experimental Medicine
Mack et al. defined active chromatin landscapes of glioblastoma stem cells (GSCs) and primary tumor specimens, revealing novel transcriptional regulatory circuits and therapeutic targets. Super-enhancers identified essential transcription factors tha
Autor:
Juan Qian, David M. Valenzuela, Jeongwu Lee, Hong Guo, Andrew J. Murphy, George D. Yancopoulos, Nickolas W. Gale, Bingcheng Wang, Aaron Petty, Jeremy N. Rich, Justin D. Lathia, Dolores Hambardzumyan, Hui Miao, James Kaspar
Publikováno v:
Oncogene
Diffuse infiltrative invasion is a major cause for the dismal prognosis of glioblastoma (GBM), but the underlying mechanisms remain incompletely understood. Using human glioblastoma stem cells (GSCs) that recapitulate the invasive propensity of prima
Autor:
Maricruz Rivera, S Minhas, Justin D. Lathia, Q Wu, Jeremy N. Rich, John M. Heddleston, Andrew E. Sloan, Anita B. Hjelmeland, Othon Iliopoulos
Publikováno v:
Cell Death & Differentiation. 19:428-439
Normal stem cells reside in functional niches critical for self-renewal and maintenance. Neural and hematopoietic stem cell niches, in particular, are characterized by restricted availability of oxygen and the resulting regulation by hypoxia-inducibl
Autor:
Justin D. Lathia, Stephen C. Mack, Claudia L.L. Valentim, Erin E. Mulkearns-Hubert, Jeremy N. Rich
Publikováno v:
Genesdevelopment. 29(12)
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and maligna