Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Srinivasan Yegnasubramanian, Jonathan W. Simons, William G. Nelson, Michael C. Haffner, Andries M. Bergman, Lodewyk F. A. Wessels, Tesa M. Severson, Matthew L. Freedman, Wilbert Zwart, Tracy Jones, Yanyun Zhu, Angelo M. De Marzo
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Autor:
Zhongyuan Zhang, W. Nathaniel Brennen, Angelo M. De Marzo, Alexandria Brame, Levent Trabzonlu, Sarah R. Amend, Denis Wirtz, Timothy E. G. Krueger, Ashley Kiemen, Amber E. de Groot, Kayla V. Myers, Kenneth J. Pienta, Vicente E Torres, Natalia H Nagy
Publikováno v:
Prostate
Background Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and
Autor:
Mohammed Alshalalfa, Peter A. Sims, Ilsa Coleman, Jaime Yeji Kim, Angelo M. De Marzo, Onur Ertunc, Junfei Zhao, Renu K. Virk, Felix Y. Feng, Min Zou, Antonina Mitrofanova, Jun Luo, Antonio Rodriguez, Cory Abate-Shen, R. Jeffrey Karnes, Julia Fountain, Hanina Hibshoosh, Juan Arriaga, Sukanya Panja, Peter S. Nelson, Raul Rabadan, Emmanuel S. Antonarakis, Arianna Giacobbe, Busra Ozbek, Chioma J. Madubata, Mark A. Rubin
Publikováno v:
Nat Cancer
Understanding the intricacies of lethal prostate cancer poses specific challenges due to difficulties in accurate modeling of metastasis in vivo. Here we show that NPKEYFP mice (for Nkx3.1CreERT2/+; Ptenflox/flox; KrasLSL-G12D/+; R26R-CAG-LSL-EYFP/+)
Autor:
Susan L. Dalrymple, Yezi Zhu, Peter S. Nelson, Jun Luo, Jianfeng Xu, Alan K. Meeker, Samuel R. Denmeade, Emmanuel S. Antonarakis, S. Lilly Zheng, William B. Isaacs, Angelo M. De Marzo, Jody E. Hooper, Ilsa Coleman, John T. Isaacs, W. Nathaniel Brennen
Publikováno v:
Oncogene
The role of truncated androgen receptor splice variant-7 (AR-V7) in prostate cancer biology is an unresolved question. Is it simply a marker of resistance to 2nd-generation androgen receptor signaling inhibitors (ARSi) like abiraterone acetate (Abi)
Autor:
Lionel Chia, Mindy K. Graham, Alan K. Meeker, Michael C. Haffner, Anthony J. Rizzo, Jacqueline A. Brosnan-Cashman, Angelo M. De Marzo, Qizhi Zheng, Javier A. Baena Del Valle, Michael Rubenstein, Michael Considine, Jiyoung Kim, Christine Davis, Leslie Cope, Joseph Da, Christopher M. Heaphy
Publikováno v:
Mol Cancer Res
A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up
Autor:
Jessica L. Hicks, Tamara L. Lotan, Angelo M. De Marzo, Ayanna M Carter, Lauren B. Peiffer, Luke Mummert, Rebecca Y Sosa, Jiayun Lu, Corinne E. Joshu, Karen S. Sfanos, Ryan Kempski, Igor Vidal, Tamirat Ali, Janielle P. Maynard
Publikováno v:
J Pathol
Prostate cancer (PCa) remains a leading cause of cancer-related deaths in American men and treatment options for metastatic PCa are limited. There is a critical need to identify new mechanisms that contribute to PCa progression, that distinguish beni
Autor:
Srinivasan Yegnasubramanian, Jiayu Chen, Sarah E. Ernst, Jessica L. Hicks, Angelo M. De Marzo, William G. Nelson, Igor Vidal, Bruce J. Trock, Javier Valle, Karen S. Sfanos, Ibrahim Kulac, Qizhi Zheng, Elizabeth A. Platz, Janielle P. Maynard, Tracy Jones, Stephanie Glavaris
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0241934 (2021)
PLOS One
PLoS ONE
PLOS One
PLoS ONE
GSTP1 is a member of the Glutathione-S-transferase (GST) family silenced by CpG island DNA hypermethylation in 90-95% of prostate cancers. However, prostate cancers expressing GSTP1 have not been well characterized. We used immunohistochemistry again
Autor:
Janielle P. Maynard, Angelo M. De Marzo, Corey M. Porter, Karen S. Sfanos, Ibrahim Kulac, Michael C. Haffner, Javier Valle, William B. Isaacs, Srinivasan Yegnasubramanian
Publikováno v:
Am J Pathol
Lactoferrin (LTF) is an iron-binding protein canonically known for its innate and adaptive immune functions. LTF may also act as a tumor suppressor with antiproliferative action. LTF is inactivated genetically or epigenetically in various cancers, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a710a412d6ff9bc890a3ef606bfbcfb2
https://europepmc.org/articles/PMC6892185/
https://europepmc.org/articles/PMC6892185/
Autor:
Donald J. Vander Griend, Calvin VanOpstall, Erin M. McAuley, Jorge Andrade, Juan Manuel Vasquez, Gladell P. Paner, Marc Gillard, Raj Bhanvadia, Hannah Brechka, Angelo M. De Marzo, Russell Z. Szmulewitz, Wen-Ching Chan, Misop Han, Nimrod S. Barashi
Publikováno v:
Clinical Cancer Research. 24:3668-3680
Purpose: Germline mutations within the MEIS-interaction domain of HOXB13 have implicated a critical function for MEIS–HOX interactions in prostate cancer etiology and progression. The functional and predictive role of changes in MEIS expression wit
Autor:
Charles J. Bieberich, Angelo M. De Marzo, Srinivasan Yegnasubramanian, David M. Esopi, Qizhi Zheng, Gretchen K. Hubbard, Apurv Rege, Jessica Hicks, Mark C. Markowski, Alexia King
Publikováno v:
Prostate
Background Loss or mutation of PTEN alleles at 10q23 in combination with 8q24 amplification (encompassing MYC) are common findings in aggressive, human prostate cancer. Our group recently developed a transgenic murine model of prostate cancer involvi