Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jean Buteau"'
Autor:
Patrick E. MacDonald, Austin Bautista, Ying Wayne Wang, Jean Buteau, Mourad Ferdaoussi, Aliya F. Spigelman, Sophie L. Lewandowski, Matthew J. Merrins, Tamadher A. Alghamdi, Yaxing Jin, Nancy Smith, Haopeng Lin, Jocelyn E. Manning Fox, Kunimasa Suzuki
Publikováno v:
Diabetes
SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific protease 1 (SENP1) following metabolic stress, we put pancreas/gut-specific
Publikováno v:
Diabetologia. 60:1432-1441
Heat shock factor protein 1 (HSF1) is a transcription factor that regulates the expression of key molecular chaperones, thereby orchestrating the cellular response to stress. This system was recently implicated in the control of insulin sensitivity a
Autor:
Tsonwin Hai, David Ron, Wendy L. Frankel, Jean Buteau, Gary J. Kociba, Dan Lu, Tala Shukri, Matthew G. Hartman, Shane T. Grey, Marc Prentki, Denis C. Guttridge, Mi Lyang Kim, Xiaozhong Wang
Publikováno v:
Molecular and Cellular Biology. 24:5721-5732
Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a member of the ATF/CREB family of transcription factors. However, the physiological significance of ATF3 induction by stress signals is not clear. In this report, we des
Publikováno v:
The Journal of biological chemistry. 289(12)
The tumor suppressor gene ST18 was originally characterized as the third member of the neural zinc finger transcription factor family. However, little is known about its biological functions. Herein, we demonstrate that, in the pancreas, ST18 express
Publikováno v:
Molecular and cellular endocrinology. 364(1-2)
Glucagon-like peptide-1 (GLP-1), a glucoincretin hormone secreted by intestinal L cells, is a potent growth factor for the pancreatic β-cell. The development of GLP-1 mimetics and enhancers as a novel class of anti-diabetes medications underpins the