Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Bart Staels"'
Autor:
Lianggong Ding, Wenfei Sun, Miroslav Balaz, Anyuan He, Manuel Klug, Stefan Wieland, Robert Caiazzo, Violeta Raverdy, Francois Pattou, Philippe Lefebvre, Irfan J. Lodhi, Bart Staels, Markus Heim, Christian Wolfrum
Publikováno v:
Nature Metabolism
Nature Metabolism, 2021, 3 (12), pp.1648-1661. ⟨10.1038/s42255-021-00489-2⟩
Nature Metabolism, Nature Publishing Group, 2021, 3 (12), pp.1648-1661. ⟨10.1038/s42255-021-00489-2⟩
Nature Metabolism, 2021, 3 (12), pp.1648-1661. ⟨10.1038/s42255-021-00489-2⟩
Nature Metabolism, Nature Publishing Group, 2021, 3 (12), pp.1648-1661. ⟨10.1038/s42255-021-00489-2⟩
To liberate fatty acids (FAs) from intracellular stores, lipolysis is regulated by the activity of the lipases adipose triglyceride lipase (ATGL), hormone-sensitive lipase and monoacylglycerol lipase. Excessive FA release as a result of uncontrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3aba8e8e184337f9b05e50886b3d0d
https://www.hal.inserm.fr/inserm-03507759
https://www.hal.inserm.fr/inserm-03507759
Publikováno v:
Epigenomics. 12:715-723
Super-enhancers (SE) have become a popular concept and are widely used as a feature defining key identity genes. Here, we provide perspectives on the use of SE to define and identify cell/tissue-identity genes. By mining SE and their associated genes
Autor:
Philippe Gailly, Anna Kreis, Karelle Leroy, Bart Staels, Nathalie Pierrot, Jean Pierre Brion, Francisco Saez-Orellana, Eric Bauge, Charles Duyckaerts, Jean-Noël Octave, Floriane Ribeiro, Thomas Leroy, Fanny Lalloyer
Publikováno v:
JCI Insight
JCI Insight, American Society for Clinical Investigation, 2021, ⟨10.1172/jci.insight.150099⟩
JCI insight, 6 (16
JCI Insight, 2021, ⟨10.1172/jci.insight.150099⟩
JCI Insight, American Society for Clinical Investigation, 2021, ⟨10.1172/jci.insight.150099⟩
JCI insight, 6 (16
JCI Insight, 2021, ⟨10.1172/jci.insight.150099⟩
Among genetic susceptibility loci associated with late-onset Alzheimer disease (LOAD), genetic polymorphisms identified in genes encoding lipid carriers led to the hypothesis that a disruption of lipid metabolism could promote disease progression. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee14c391640ff77c086cb59c2c3a440
https://hal.sorbonne-universite.fr/hal-03280763/file/150099.1-20210701105952-covered-e0fd13ba177f913fd3156f593ead4cfd.pdf
https://hal.sorbonne-universite.fr/hal-03280763/file/150099.1-20210701105952-covered-e0fd13ba177f913fd3156f593ead4cfd.pdf
Autor:
Denis A. Mogilenko, Delphine Staumont-Sallé, Geert van Loo, Wim Declercq, Peter Vandenabeele, Michael Devos, David Dombrowicz, Peter Tougaard, C. Becquart, Claus Bachert, Sandrine Quemener, Bart Staels, Barbara Gilbert, Hélène Dehondt, Sébastien Fleury
Publikováno v:
Journal of Investigative Dermatology. 139:135-145
Keratinocytes are key players in chronic inflammatory skin diseases. A20 regulates NF-κB-dependent expression of proinflammatory genes and cell death, but the impact of its expression in keratinocytes on systemic inflammation and skin disorders has
Autor:
François Pattou, Violeta Raverdy, Steve Lancel, Gregory Baud, Alexis Boulinguiez, Christian Duhem, Hélène Duez, Hélène Verkindt, Robert Caiazzo, Bart Staels, Camille Marciniak
Publikováno v:
Acta Diabetologica
Acta Diabetologica, 2020, 57 (7), pp.819-826. ⟨10.1007/s00592-020-01490-z⟩
Acta Diabetologica, Springer Verlag, 2020, 57 (7), pp.819-826. ⟨10.1007/s00592-020-01490-z⟩
Acta Diabetologica, Springer Verlag, 2020, ⟨10.1007/s00592-020-01490-z⟩
Acta Diabetologica, 2020, 57 (7), pp.819-826. ⟨10.1007/s00592-020-01490-z⟩
Acta Diabetologica, Springer Verlag, 2020, 57 (7), pp.819-826. ⟨10.1007/s00592-020-01490-z⟩
Acta Diabetologica, Springer Verlag, 2020, ⟨10.1007/s00592-020-01490-z⟩
International audience; AIMS:Not all people with obesity become glucose intolerant, suggesting differential activation of cellular pathways. The unfolded protein response (UPR) may contribute to the development of insulin resistance in several organs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b47d963840df2752a56cf4bf3e6fb8
https://www.hal.inserm.fr/inserm-02488979
https://www.hal.inserm.fr/inserm-02488979
Autor:
David Montaigne, Bart Staels
Publikováno v:
Circulation Research. 123:648-650
Autor:
Dicky Struik, Niels Hellings, Anja Kerksiek, Melissa Schepers, Ilse Dewachter, Frank P.J. Leijten, Johan W. Jonker, Yupyn Chintapakorn, Thiti Suttiyut, Monique T. Mulder, Hong-Bing Liu, Tim Vanmierlo, Eric J.G. Sijbrands, Jochen Walter, Surachai Pornpakakul, Jeroen F. J. Bogie, Dieter Lütjohann, Assia Tiane, Bart Staels, Ann Cuypers, Albert K. Groen, Jerome J. A. Hendriks, Cindy Hoeks, Pilar Martinez-Martinez
Publikováno v:
Scientific reports, 9(1):4908. Nature Publishing Group
Scientific Reports
Scientific Reports, 9:4908. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, 9(1):4908. Nature Publishing Group
Scientific Reports
Scientific Reports, 9:4908. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, 9(1):4908. Nature Publishing Group
Activation of liver X receptors (LXRs) by synthetic agonists was found to improve cognition in Alzheimer’s disease (AD) mice. However, these LXR agonists induce hypertriglyceridemia and hepatic steatosis, hampering their use in the clinic. We hypot
Autor:
Agnès Hovasse, Manjula Vinod, Jérôme Eeckhoute, Jeremy Alexandre, Alexandre Berthier, Julie Dubois-Chevalier, Fabrice Bray, Maheul Ploton, Xavier Marechal, Bart Staels, Christine Schaeffer-Reiss, Agata Steenackers, Hélène Duez, Philippe Lefebvre, Geoffrey Porez, Sarah Cianférani, Christian Rolando, Nao Yamakawa, Céline Gheeraert, Tony Lefebvre
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (47), pp.11033-11042. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, Epub ahead of print. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (47), pp.11033-11042. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (47), pp.11033-11042. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, Epub ahead of print. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (47), pp.11033-11042. ⟨10.1073/pnas.1805397115⟩
Significance Using an interactomic approach, we have identified the nuclear receptor REV-ERBα as a O-GlcNAc transferase (OGT) protein partner. REV-ERBα protects cytoplasmic OGT from proteasomal degradation and facilitates cytosolic and nuclear prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fffa5683cae464f4eb9d55a699cd33
https://www.hal.inserm.fr/inserm-01924835/document
https://www.hal.inserm.fr/inserm-01924835/document
Autor:
Manjula Vinod, Corinne Copin, Giulia Chinetti-Gbaguidi, Stéphan Haulon, Bart Staels, Sophie Susen, Bruno Derudas, Christophe Zawadzki, Jonathan Vanhoutte, Federica De Paoli, François Pattou, Jérôme Eeckhoute
Publikováno v:
FEBS Letters. 590:43-52
Macrophages display heterogeneous phenotypes, including the classical M1 proinflammatory and the alternative M2 anti-inflammatory polarization states. The transducin-like enhancer of split-1 (TLE1) is a transcriptional corepressor whose functions in
Autor:
Philippe Lefebvre, Mathieu Lupien, Jérôme Eeckhoute, Parisa Mazrooei, Bart Staels, Julie Dubois-Chevalier
Publikováno v:
Transcription
Transcription, 2018, 9 (4), pp.233-239. ⟨10.1080/21541264.2017.1394424⟩
Transcription, Taylor & Francis, 2018, 9 (4), pp.233-239. ⟨10.1080/21541264.2017.1394424⟩
PubMed Central
Transcription, 2018, 9 (4), pp.233-239. ⟨10.1080/21541264.2017.1394424⟩
Transcription, Taylor & Francis, 2018, 9 (4), pp.233-239. ⟨10.1080/21541264.2017.1394424⟩
PubMed Central
International audience; Gene transcriptional regulation relies on cis-regulatory DNA modules (CRMs), which serve as nexus sites for integration of multiple transcription factor (TF) activities. Here, we provide evidence and discuss recent literature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42dc9c2373cc18fd69eedf09fa8ada8d
https://europepmc.org/articles/PMC6104691/
https://europepmc.org/articles/PMC6104691/