Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tetsuya Oguri"'
Autor:
Tetsuya Oguri, Hiroaki Ozasa, Ken Maeno, Osamu Takakuwa, Shigeki Sato, Mikinori Miyazaki, Ryuzo Ueda, Takehiro Uemura
Publikováno v:
Cancer Science. 101:2404-2410
We have previously shown that overexpression of thymidylate synthetase (TS) resulted in pemetrexed (MTA) resistance. To investigate another mechanism of MTA resistance, we investigated the expression of ATP-binding cassette (ABC)-transporters in MTA-
Autor:
Takehiro Uemura, Hiroaki Ozasa, Yuji Bessho, Ken Maeno, Tetsuya Oguri, Hiroyoshi Maeda, Ryuzo Ueda, Shigeki Sato, Mikinori Miyazaki
Publikováno v:
Molecular Cancer Therapeutics. 7:1150-1155
We used the paclitaxel-resistant human small cell lung cancer subline PC-6/TAX1-1, selected from PC-6 cells by paclitaxel, to test whether MRP7/ABCC10 (ABCC10) confers paclitaxel resistance. We found that gene expression of both ABCB1/MDR1 (ABCB1) an
Autor:
Hideki Muramatsu, Yuko Takano, Mikinori Miyazaki, Shigeki Sato, Tetsuya Oguri, Hiroyuki Achiwa, Takashi Niimi, Hiroyoshi Maeda, Yuji Bessho, Ryuzo Ueda
Publikováno v:
Molecular Cancer Therapeutics. 5:1800-1806
We examined the expression levels of the multidrug resistance protein 5 (ABCC5) gene in non–small cell lung cancer (NSCLC) cell lines to clarify the relationship with the sensitivity to gemcitabine. The expression levels of ABCC5 were inversely cor
Publikováno v:
Cancer Chemotherapy and Pharmacology. 48:42-46
Several recent studies have demonstrated that the cytochrome p450 (CYP) family plays an important role in the metabolism of taxanes. However, the role of CYP gene expression in tumors and peripheral mononuclear cells (PMN) is unknown. We therefore in
Publikováno v:
International Journal of Cancer. 93:584-589
To investigate the roles played by the multidrug resistance-associated protein (MRP1) homologues MRP3 and MRP4 in resistance to platinum drugs, we examined steady-state levels of mRNA for both MRP3 and MRP4 in normal lung and lung cancer specimens as
Autor:
Yasuhiro Fujiwara, Osamu Katoh, Nobuhisa Ishikawa, Michiya Yokozaki, Shinichi Ishioka, Takeshi Isobe, Tetsuya Oguri, Masahiro Yamasaki, Haruko Daga, Michio Yamakido, Kazunori Fujitaka
Publikováno v:
Cancer Letters. 156:93-99
We examined the association between the gene expression levels of glutathione S-transferase-pi (GST-pi) and platinum drug exposure in human lung cancer. First we monitored GST-pi gene expression levels in two lung cancer cell lines and in peripheral
Autor:
Osamu Katoh, Kazuto Nishio, Yasuhiro Fujiwara, Michio Yamakido, Tetsuya Oguri, Toshihiro Suzuki, Takeshi Isobe
Publikováno v:
International Journal of Cancer. 86:95-100
To investigate the role of the multidrug resistance-associated protein (MRP1) homologue MRP5 in relation to platinum drug resistance, we examined the steady-state levels of the mRNAs for MRP5 in both lung cancer cell lines and peripheral mononuclear
Publikováno v:
Japanese Journal of Cancer Research : Gann
We examined the expression levels of mRNA for multidrug resistance 1 (MDR1), multidrug resistance-associated protein (MRP), human canalicular multispecific organic anion transporter (cMOAT), lung resistance-related protein (LRP), topoisomerase IIalph
Publikováno v:
Japanese Journal of Cancer Research : Gann
Glucose uptake is mediated by members of the facilitative glucose transporter (GLUT) family. Malignant cells take up more glucose than their normal counterparts. The aim of this study was to investigate the gene expression levels of the GLUT family,
Autor:
Michio Yamakido, Tetsuya Oguri, Takeshi Isobe, Toshiaki Takahashi, Elisna Syahruddin, Yasuhiro Fujiwara
Publikováno v:
Japanese Journal of Cancer Research : Gann
DNA topoisomerase II (Topo II) inhibitors are widely used in lung cancer chemotherapy, but small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) show different sensitivity to them. In this study, we examined the gene expression levels