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Autor:
Mandaviya, Pooja, Joehanes, Roby, Aïssi, Dylan, Kühnel, Brigitte, Marioni, Riccardo, Truong, Vinh, Stolk, Lisette, Beekman, Marian, Bonder, Jan, Franke, Lude, Gieger, Christian, Huan, Tianxiao, Ikram, M. Arfan, Kunze, Sonja, Liang, Liming, Lindemans, Jan, Liu, Chunyu, McRae, Allan, Mendelson, Michael, Müller-Nurasyid, Martina, Peters, Annette, Slagboom, P. Eline, Starr, John, Trégouët, David-Alexandre, Uitterlinden, Andre, van Greevenbroek, Marleen, Van Heemst, Diana, van Iterson, Maarten, Wells, Philip, Yao, Chen, Deary, Ian, Gagnon, France, Heijmans, Bastiaan, Lévy, Daniel, Morange, Pierre-Emmanuel, Waldenberger, Melanie, Heil, Sandra, van Meurs, Joyce, Zeller, Tanja, Kü Hnel, Brigitte, Bonder, Marc, Tré Gouë T, David-Alexandre, Uitterlinden, André
Publikováno v:
PLoS ONE
PLoS One (online), 12(10):e0182472. Public Library of Science
PLoS ONE, 12(10):e0182472. PUBLIC LIBRARY SCIENCE
PLoS ONE, Public Library of Science, 2017, 12 (10), ⟨10.1371/journal.pone.0182472⟩
PLoS ONE, 12(10)
PLoS ONE 12:e0182472 (2017)
PLoS ONE, 2017, 12 (10), ⟨10.1371/journal.pone.0182472⟩
PLOS ONE, 12(10):0182472. Public Library of Science
Plos One 10 (12), . (2017)
PLoS ONE, Vol 12, Iss 10, p e0182472 (2017)
Mandaviya, P R, Joehanes, R, Aïssi, D, Kühnel, B, Marioni, R E, Truong, V, Stolk, L, Beekman, M, Bonder, M J, Franke, L, Gieger, C, Huan, T, Ikram, M A, Kunze, S, Liang, L, Lindemans, J, Liu, C, McRae, A F, Mendelson, M M, Müller-Nurasyid, M, Peters, A, Slagboom, P E, Starr, J M, Trégouët, D-A, Uitterlinden, A G, van Greevenbroek, M M J, van Heemst, D, van Iterson, M, Wells, P S, Yao, C, Deary, I J, Gagnon, F, Heijmans, B T, Levy, D, Morange, P-E, Waldenberger, M, Heil, S G, van Meurs, J B J 2017, ' Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes ', PLoS ONE, vol. 12, no. 10, e0182472, pp. 1-19 . https://doi.org/10.1371/journal.pone.0182472
PLoS One (online), 12(10):e0182472. Public Library of Science
PLoS ONE, 12(10):e0182472. PUBLIC LIBRARY SCIENCE
PLoS ONE, Public Library of Science, 2017, 12 (10), ⟨10.1371/journal.pone.0182472⟩
PLoS ONE, 12(10)
PLoS ONE 12:e0182472 (2017)
PLoS ONE, 2017, 12 (10), ⟨10.1371/journal.pone.0182472⟩
PLOS ONE, 12(10):0182472. Public Library of Science
Plos One 10 (12), . (2017)
PLoS ONE, Vol 12, Iss 10, p e0182472 (2017)
Mandaviya, P R, Joehanes, R, Aïssi, D, Kühnel, B, Marioni, R E, Truong, V, Stolk, L, Beekman, M, Bonder, M J, Franke, L, Gieger, C, Huan, T, Ikram, M A, Kunze, S, Liang, L, Lindemans, J, Liu, C, McRae, A F, Mendelson, M M, Müller-Nurasyid, M, Peters, A, Slagboom, P E, Starr, J M, Trégouët, D-A, Uitterlinden, A G, van Greevenbroek, M M J, van Heemst, D, van Iterson, M, Wells, P S, Yao, C, Deary, I J, Gagnon, F, Heijmans, B T, Levy, D, Morange, P-E, Waldenberger, M, Heil, S G, van Meurs, J B J 2017, ' Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes ', PLoS ONE, vol. 12, no. 10, e0182472, pp. 1-19 . https://doi.org/10.1371/journal.pone.0182472
BackgroundDNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildly