Zobrazeno 1 - 10
of 496
pro vyhledávání: '"11"'
Autor:
Chen Xie, Liping Su, Sebastian Schafer, Sze-Yun Lim, Xiu-Yi Kwek, W. Lim, Benjamin Ng, Nicole S. J. Ko, Stuart A. Cook, Anissa A. Widjaja, Stella Lim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-sp
Autor:
Robert J. Homer, Geoffrey L. Chupp, Zhou Zhu, Jingming Wang, Tao Zheng, Jack A. Elias, Paul W. Noble, Qutayba Hamid, Chun Guen Lee
Publikováno v:
American journal of respiratory and critical care medicine. 164(10 Pt 2)
Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, a
Autor:
Suren R. Sooranna, Bronwen R. Herbert, Steven M. Yellon, Anya Das, Mark R. Johnson, Gavin Sooranna, Natasha Singh
Publikováno v:
Biol Reprod
Preterm labor (PTL) is the predominant cause of childhood morbidity and mortality. It has several phenotypes, each with a distinct etiology often involving inflammation. Here, in samples of reproductive tissues obtained in early PTL from women with p
Autor:
Daniel Todd, David W. Burt, Peter K. Kaiser, Tuanjun Hu, A. N. J. Scott, Efstathios S. Giotis, Richard Talbot, Lisa Rothwell, Elizabeth Glass
Publikováno v:
Giotis, E S, Scott, A, Rothwell, L, Hu, T, Talbot, R, Todd, D, Burt, D W, Glass, E J & Kaiser, P 2018, ' Chicken anaemia virus evades host immune responses in transformed lymphocytes ', Journal of General Virology, vol. 99, no. 3, pp. 321-327 . https://doi.org/10.1099/jgv.0.001011
Chicken anaemia virus (CAV) is a lymphotropic virus that causes anaemia and immunosuppression in chickens. Previously, we proposed that CAV evades host antiviral responses in vivo by disrupting T-cell signalling, but the precise cellular targets and
Autor:
Amy Winship, Evdokia Dimitriadis
Publikováno v:
Placenta. 50:99-101
Decidual inflammation and inflammasome activation contribute to the pathogenesis of preterm birth (PTB). Interleukin-(IL)11 exerts complex regulatory effects on inflammation and IL-11 protein is elevated in PTB decidua. We aimed to determine a functi
IL-2 modulates Th2 cell responses to glucocorticosteroid: A cause of persistent type 2 inflammation?
Autor:
Harissios Vliagoftis, Lauren A. Solomon, Meerah Vijeyakumaran, Lisa Cameron, Nami Shrestha Palikhe, Tharsan Kanagalingam
Publikováno v:
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease, Vol 7, Iss 3, Pp 112-124 (2019)
Immunity, Inflammation and Disease, Vol 7, Iss 3, Pp 112-124 (2019)
Background Glucocorticosteroids (GCs) are the main treatment for asthma as they reduce type 2 cytokine expression and induce apoptosis. Asthma severity is associated with type 2 inflammation, circulating Th2 cells and higher GC requirements. Objectiv
Publikováno v:
Journal of the Korean Society of Food Science and Nutrition. 42:1552-1559
Rubus coreanus Miquel (RCM) has been used as one of the Korean traditional medicines for prostate health. In addition, recent studies have reported that RCM reduced chronic inflammatory diseases such as cancer, and rheumatoid arthritis. Therefore, in
Autor:
Per Bakke, Ratko Djukanovic, Paolo Montuschi, Christos Rossios, René Lutter, Bertrand De Meulder, Kian Fan Chung, Uruj Hoda, Ana R. Sousa, Massimo Caruso, Stelios Pavlidis, Matthew J. Loza, Peter J. Sterk, F. Baribaud, Yike Guo, Ian M. Adcock, Pascal Chanez, Dominic E. Shaw, Francois Ng Kee Kwong, Louise Fleming, Ildiko Horvath, Jacek Musiał, Steve J. Fowler, Norbert Krug, Kai Sun, Barbro Dahlén, Florian Singer, Kentaro Takahashi, Charles Auffray, Diane Lefaudeux, Peter H. Howarth, SE Dahlen, Julie Corfield, Thomas Sandström
Publikováno v:
U-BIOPRED Study Group & Fowler, S J 2018, ' Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED : An exploratory analysis ', European Respiratory Journal, vol. 51, no. 5, 1702173 . https://doi.org/10.1183/13993003.02173-2017
European respiratory journal, 51(5):1702173. European Respiratory Society
European respiratory journal, 51(5):1702173. European Respiratory Society
Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes.The U-BIOPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc3d20151675d62ba29b3c941e4b95f
https://eprints.soton.ac.uk/418512/
https://eprints.soton.ac.uk/418512/
Autor:
Vinko Tosevski, Michaela Caj, Michael Fried, Martin Hausmann, P. Cippà, B. L. McRae, C. L. Graff, Gerhard Rogler, M. Mozaffari, Christian Lutz
Publikováno v:
Clinical and Experimental Immunology. 181:343-356
Summary Exaggerated activation of lymphocytes contributes to the pathogenesis of inflammatory bowel disease (IBD). Medical therapies are linked to the BCL-2 family-mediated apoptosis. Imbalance in BCL-2 family proteins may cause failure in therapeuti
Autor:
Yuanrong Dai, Xuejun Qin, Songmin Ying, Jiesen Zhou, Fang Liu, Zhihua Chen, Wen Li, Huahao Shen, Yuehai Ke, Zhangwei Qiu
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177334 (2017)
PLoS ONE
PLoS ONE
Shp2 played an important role in cigarette-smoke-mediated inflammation, surfactant homeostasis and asthmatic airway remodeling. However, whether shp2 plays a key role in epithelium-associated allergic reaction is still unknown. In this study, LPS and