Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael P. Meers"'
Autor:
Carrie Myers, Steven J. Wu, Michael P. Meers, James M. Olson, Derek H. Janssens, Kami Ahmad, Steven Henikoff, Jay F. Sarthy
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-14 (2018)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introduced CUT&R
Autor:
Ekaterina Babaeva, Jay F. Sarthy, Michael P. Meers, Steven J. Wu, Soheil Meshinchi, Steven Henikoff, Kami Ahmad, Derek H. Janssens
Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving the Mixed Lineage Leukemia-1 gene, encoding the KMT2A lysine methyltransferase. The most common translocations produce in-frame fusions of KMT2A to other chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e807663e7e6bdc2a0c3a05bfd95d8a22
https://doi.org/10.1101/2020.10.06.328948
https://doi.org/10.1101/2020.10.06.328948
Autor:
Nicholas A Vitanza, Jay F. Sarthy, Christina M. Lockwood, Steven Henikoff, Patrick J. Paddison, Michael P. Meers, James M. Olson, Kami Ahmad, Heather Feldman, Derek H. Janssens, Jorja G. Henikoff
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown ho
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Autor:
Robert J. Duronio, Taylor J.R. Penke, A. Gregory Matera, Mary Leatham-Jensen, Michael P. Meers, Daniel J. McKay
Publikováno v:
Methods in Molecular Biology ISBN: 9781493986620
Histone post-translational modifications (PTMs) are thought to participate in a range of essential molecular and cellular processes, including gene expression, replication, and nuclear organization. Importantly, histone PTMs are also thought to be pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f52f8f5fb78a198195d55f8916b0677
https://doi.org/10.1007/978-1-4939-8663-7_17
https://doi.org/10.1007/978-1-4939-8663-7_17
Autor:
A. Gregory Matera, Michael P. Meers, Karen Adelman, Robert J. Duronio, Daniel J. McKay, Brian D. Strahl, Christopher A. Lavender, Telmo Henriques
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in D
Publikováno v:
RNA (New York, N.Y.). 19(11)
Reduced levels of survival motor neuron (SMN) protein lead to a neuromuscular disease called spinal muscular atrophy (SMA). Animal models of SMA recapitulate many aspects of the human disease, including locomotion and viability defects, but have thus