Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jack Satsangi"'
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Crohn’s disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicat
Autor:
Renata D'Incà, Vlatka Zoldoš, Aleksandar Vojta, Jerko Štambuk, Gordan Lauc, Paula Dobrinić, Nicholas A. Kennedy, Ivana Samaržija, Mirna Šimurina, Genadij Razdorov, Jack Satsangi, Ana M. Dias, Marija Klasić, Dora Markulin, Nicholas T. Ventham, Anna Latiano, Ivan Biruš, Vito Annese, Salomé S. Pinho, Irena Trbojević-Akmačić
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
2018, ' Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease ', Clinical Epigenetics, vol. 10, pp. 75 . https://doi.org/10.1186/s13148-018-0507-y
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
2018, ' Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease ', Clinical Epigenetics, vol. 10, pp. 75 . https://doi.org/10.1186/s13148-018-0507-y
Background: Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic chan
Autor:
Natalie J. Prescott, Holm H. Uhlig, Alison Simmons, William G. Newman, Loukas Moutsianas, David C. Wilson, Sun-Gou Ji, John C. Mansfield, Christopher J. Hawkey, Graham A. Heap, Cathryn Edwards, Charlie W. Lees, Javier Gutierrez-Achury, James Lee, Nicholas A. Kennedy, Christopher A. Lamb, Jeffrey C. Barrett, Craig Mowat, Christopher G. Mathew, Jack Satsangi, Yang Luo, Daniel L. Rice, Carl A. Anderson, Paul Henderson, Ailsa Hart, Jeremy D. Sanderson, Tariq Ahmad, Elaine R. Nimmo, Mark Tremelling, Luke Jostins, Miles Parkes, Katrina M. de Lange
Publikováno v:
de Lange, K M, Moutsianas, L, James C. Lee, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Mathew, C G, Newman, W, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. ', Nature Genetics, vol. 49, pp. 256–261 . https://doi.org/10.1038/ng.3760
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowatt, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Matthew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256–261 . https://doi.org/10.1038/ng.3760
Nature genetics
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Mathew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256-261 . https://doi.org/10.1038/ng.3760
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowatt, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Matthew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256–261 . https://doi.org/10.1038/ng.3760
Nature genetics
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Mathew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256-261 . https://doi.org/10.1038/ng.3760
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals and conducted a meta-analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aa2a61e5e4729a3800e31b8cb129e0
https://doi.org/10.1038/ng.3760
https://doi.org/10.1038/ng.3760
Autor:
Graham A. Heap, James Lee, Nicholas A. Kennedy, Cathryn Edwards, Ailsa Hart, Daniel L. Rice, Javier Gutierrez-Achury, Christopher J. Hawkey, Jeremy D. Sanderson, Luke Jostins, Miles Parkes, Katrina M. de Lange, Mark Tremelling, David C. Wilson, Jeffrey C. Barrett, Carl A. Anderson, William G. Newman, Sun-Gou Ji, Elaine R. Nimmo, Paul Henderson, Natalie J. Prescott, Jack Satsangi, Christopher G. Mathew, Loukas Moutsianas, Yang Luo, Charlie W. Lees, Alison Simmons, Tariq Ahmad, Holm H. Uhlig, John C. Mansfield, Craig Mowat, Christopher A. Lamb
Genetic association studies have identified 210 risk loci for inflammatory bowel disease1–7, which have revealed fundamental aspects of the molecular biology of the disease, including the roles of autophagy and Th17 cell signaling and development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700dc483893cae56ee720e56c1510179
https://doi.org/10.1101/058255
https://doi.org/10.1101/058255
Autor:
Elaine R. Nimmo, Jack Satsangi, Colin Veal, Christopher G. Mathew, I. Vind, Peder Fode, Pia S. Munkholm, Edward J. Hollox, Natalie J. Prescott, John C. Mansfield, Paal Skyt Andersen, Shamik Polley
Publikováno v:
Polley, S, Prescott, N, Nimmo, E, Veal, C, Vind, I, Munkholm, P, Fode, P, Mansfield, J, Skyt Andersen, P, Satsangi, J, G Mathew, C & Hollox, E J 2016, ' Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn's disease ', European journal of human genetics : EJHG . https://doi.org/10.1038/ejhg.2015.280
Polley, S, Prescott, N, Nimmo, E, Veal, C, Vind, I, Munkholm, P, Fode, P, Mansfield, J, Skyt Andersen, P, Satsangi, J, Matthew, C G & Hollox, E J 2016, ' Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn's disease ', European Journal of Human Genetics . https://doi.org/10.1038/ejhg.2015.280
European Journal of Human Genetics
Polley, S, Prescott, N, Nimmo, E, Veal, C, Vind, I, Munkholm, P, Fode, P, Mansfield, J, Skyt Andersen, P, Satsangi, J, Matthew, C G & Hollox, E J 2016, ' Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn's disease ', European Journal of Human Genetics . https://doi.org/10.1038/ejhg.2015.280
European Journal of Human Genetics
Previous work has shown that the gene DMBT1, which encodes a large secreted epithelial glycoprotein known as salivary agglutinin, gp340, hensin or muclin, is an innate immune defence protein that binds bacteria. A deletion variant of DMBT1 has been p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1cd17bf71a1d8099ae198def90afc0
https://kclpure.kcl.ac.uk/ws/files/46527839/ejhg2015280a.pdf
https://kclpure.kcl.ac.uk/ws/files/46527839/ejhg2015280a.pdf
Autor:
Nicholas T. Ventham, Jack Satsangi, Ray Boyapati, Adriano G. Rossi, David A. Dorward, Rahul Kalla, Arina Tamborska, Gwo-Tzer Ho
Publikováno v:
Journal of Crohn's and Colitis. 11:S105-S106
Publikováno v:
Human Molecular Genetics. 15:797-805
Several lines of evidence suggest a role for the multidrug resistance gene (ABCB1/MDR1) and its product, P-glycoprotein 170, in the pathogenesis of inflammatory bowel disease (IBD). In addition, P-glycoprotein activity determines bioavailability of m
Publikováno v:
Inflammatory Bowel Diseases. 11:1013-1019
The chronic idiopathic inflammatory bowel diseases (IBDs), Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by an overly aggressive cell-mediated immune response to luminal commensal bacteria in genetically susceptible individual
Publikováno v:
Gastroenterology. 152:S79