Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ida J. van der Klei"'
Publikováno v:
Biochemical and Biophysical Research Communications, 480(2), 228-233. ACADEMIC PRESS INC ELSEVIER SCIENCE
The non-bilayer forming lipids cardiolipin (CL) and phosphatidylethanolamine (PE) modulate membrane curvature, facilitate membrane fusion and affect the stability and function of membrane proteins. Yeast peroxisomal membranes contain significant amou
Publikováno v:
Biochimica et biophysica acta, 1863(5):17661, 902-910
This contribution describes the phenotypic differences of yeast peroxisome-deficient mutants (pex mutants). In some cases different phenotypes were reported for yeast mutants deleted in the same PEX gene. These differences are most likely related to
Publikováno v:
Autophagy, 9(7), 1044-1056. Taylor & Francis Group
We demonstrated that in the yeast Hansenula polymorpha peroxisome fission and degradation are coupled processes that are important to remove intra-organellar protein aggregates. Protein aggregates were formed in peroxisomes upon synthesis of a mutant
Publikováno v:
Metabolic Engineering, 18, 36-43. ACADEMIC PRESS INC ELSEVIER SCIENCE
Genetic engineering of fungal cell factories mainly focuses on manipulating enzymes of the product pathway or primary metabolism. However, despite the use of strong promoters or strains containing the genes of interest in multiple copies, the desired
Autor:
Jan A.K.W. Kiel, Richard J.S. Baerends, Ruchi Saraya, Arjen M Krikken, Marten Veenhuis, Ida J. van der Klei
Publikováno v:
Fems Yeast Research. 12(3):271-278
Hansenula polymorpha is an important yeast in industrial biotechnology. In addition, it is extensively used in fundamental research devoted to unravel the principles of peroxisome biology and nitrate assimilation. Here we present an overview of key c
Autor:
Roel A. L. Bovenberg, Marten Veenhuis, Magdalena Bartoszewska, Ida J. van der Klei, Jan A.K.W. Kiel
Publikováno v:
Applied and environmental microbiology, 77(4), 1413-1422. AMER SOC MICROBIOLOGY
We have investigated the significance of autophagy in the production of the β-lactam antibiotic penicillin (PEN) by the filamentous fungus Penicillium chrysogenum . In this fungus PEN production is compartmentalized in the cytosol and in peroxisomes
Autor:
Jan A.K.W. Kiel, Ida J. van der Klei
Publikováno v:
Fungal Genetics and Biology, 46(1), S62-S71. ACADEMIC PRESS INC ELSEVIER SCIENCE
Fungal microbodies (peroxisomes) are inducible organelles that Proliferate in response to nutritional Cues. Proteins involved in peroxisome biogenesis/proliferation are designated peroxins and are encoded by PEX genes. An autophagy-related process, t
Publikováno v:
FEBS Letters, 581(29), 5627-5634. Wiley
We have analyzed the highly conserved N-terminus of Hansenula polymorpha Pex14p for its function in peroxisomal matrix protein import. The region comprising aa 10-54 of HpPex14p is predicted to contain three alpha-helices. Its alpha-helical structure
Publikováno v:
Fems Yeast Research, 7(7), 1093-1102
We report on the rerouting of peroxisomal alcohol oxidase (AO) to the secretory pathway of Hansenula polymorpha. Using the leader sequence of the Saccharomyces cerevisiae mating factor alpha (MF alpha) as sorting signal, AO was correctly sorted to th
Autor:
Ida J. van der Klei, Eva Liebminger, Alice Lebreton, Gertrude Zisser, Lisa Kappel, Brigitte Pertschy, Alain Jacquier, Martin Tengg, Gregor Högenauer, Berthold Nobis, Helmut Bergler, Cosmin Saveanu, Micheline Fromont-Racine
Publikováno v:
Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩
Molecular and Cellular Biology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩
Molecular and Cellular Biology, 27(19), 6581-6592. AMER SOC MICROBIOLOGY
Molecular and Cellular Biology 19 (27), 6581-6592. (2007)
Molecular and Cellular Biology, American Society for Microbiology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩
Molecular and Cellular Biology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩
Molecular and Cellular Biology, 27(19), 6581-6592. AMER SOC MICROBIOLOGY
Molecular and Cellular Biology 19 (27), 6581-6592. (2007)
International audience; Allelic forms of DRG1/AFG2 confer resistance to the drug diazaborine, an inhibitor of ribosome biogenesis in Saccharomyces cerevisiae. Our results show that the AAA-ATPase Drg1 is essential for 60S maturation and associates wi