Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Eckhard Wolf"'
Autor:
Alessandra Moretti, Wolfgang Wurst, Alina Windisch, Maggie C. Walter, Eckhard Wolf, Christian Kupatt
Publikováno v:
Gene Therapy
Gene therapy 28(9), 542-548 (2021). doi:10.1038/s41434-021-00222-4
Gene Ther. 28, 542–548 (2021)
Gene therapy 28(9), 542-548 (2021). doi:10.1038/s41434-021-00222-4
Gene Ther. 28, 542–548 (2021)
Mutations in Dystrophin, one of the largest proteins in the mammalian body, are causative for a severe form of muscle disease, Duchenne Muscular Dystrophy (DMD), affecting not only skeletal muscle, but also the heart. In particular, exons 45–52 con
Autor:
Daniel Wise, Harald Luksch, Lucie Carrier, James C. Kaufman, Lutz Kettler, Nina Simm, Tatiana Flisikowska, Tarik Bozoglu, Carolin Perleberg, Benedikt B. Kaufer, Denise Duda, Valeri Zakhartchenko, Hicham Sid, Antonina Schlickenrieder, Mayuko Kurome, Angelika Schnieke, Eckhard Wolf, Beate Rieblinger, Christian Kupatt, Ibrahim T. Hagag, Alessandro Grodziecki, Barbara Kessler, Kamila Lengyel, Krzysztof Flisikowski, Benjamin Schusser, Andrea Bähr, Romina Klinger
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Genetically modified animals are crucial for functional studies and translational biomedical research. However, the generation of genome-edited large animals is time consuming and inefficient. Here, we report the generation of transgenic
Autor:
Benjamin Schusser, Romina Hellmich, Eckhard Wolf, Denise Bartsch, Daniel Wise, Krzysztof Flisikowski, Harald Luksch, Hicham Sid, Antonina Schlickenrieder, Beate Rieblinger, Lutz Kettler, James C. Kaufman, Benedikt B. Kaufer, Christian Kupatt, Nina Simm, Angelika Schnieke, Ibrahim T. Hagag, Kamila Lengyel, Alessandro Grodziecki, Tatiana Flisikowska, Barbara Kessler, Carolin Perleberg
Genetically modified animals continue to provide important insights in biomedical sciences. Research has focused mostly on genetically modified mice so far, but other species like pigs resemble more closely the human physiology. In addition, cross-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defe8dc1a84796c8c7906b790e943e58
https://doi.org/10.1101/2020.04.01.019679
https://doi.org/10.1101/2020.04.01.019679
Autor:
Ayuko Uchikura, Hitomi Matsunari, A. Wuensch, Shin Enosawa, Kazuaki Nakano, Nikolai Klymiuk, Barbara Kessler, Hiroshi Nagashima, Hiromitsu Nakauchi, Masahito Watanabe, Toru Fukuda, Yutaka Hanazono, Akihiro Umezawa, Kazuhiro Umeyama, Sayaka Yashima, Masaki Nagaya, Mayuko Kurome, Valeri Zakhartchenko, Eckhard Wolf
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The development of therapies for rare and intractable genetic disorders represents a significant unmet medical need. Disease model pigs characterized by physiological, anatomical, and pathogenetic similarities to humans allow translation
Autor:
Beatrix Foerster, Nikolai Klymiuk, Elisabeth Kemter, Valeri Zakhartchenko, Mayuko Kurome, Eckhard Wolf, Simon Leuchs, Eva-Maria Jemiller, Barbara Kessler
Publikováno v:
Transgenic Research. 26:309-318
Due to a rising demand of porcine models with complex genetic modifications for biomedical research, the approaches for their generation need to be adapted. In this study we describe the direct introduction of a gene construct into the pronucleus (PN
Autor:
Florian Geier, Virginie Tissières, Javier Lopez-Rios, Eckhard Wolf, Rolf Zeller, Barbara Kessler
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports
Cell Reports, Vol 31, Iss 1, Pp-(2020)
instname
Cell Reports
Cell Reports, Vol 31, Iss 1, Pp-(2020)
Summary Digit loss/reductions are evolutionary adaptations in cursorial mammals such as pigs. To gain mechanistic insight into these processes, we performed a comparative molecular analysis of limb development in mouse and pig embryos, which revealed
Within the mammalian class, formation of the blastocyst is morphologically highly conserved among different species. The molecular and cellular events during preimplantation embryo development have been studied extensively in the mouse as model organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9ff2ea214879acf2785fe2a7704c17
https://europepmc.org/articles/PMC6133330/
https://europepmc.org/articles/PMC6133330/
Autor:
Eckhard Wolf, Helmut Blum, A. Beck, Stefan Krebs, Valeri Zakhartchenko, Ilaria Lavagi, Kilian Simmet
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Embryonic development is initially controlled by maternal RNAs and proteins stored in the oocyte, until gene products gradually generated by the embryo itself take over. Major embryonic genome activation (EGA) in bovine embryos occurs at the eight- t
Functional dissection of the insulin-like growth factor (IGF) svstem – prospects for animal breeding
Growth is a biological phenomenon that is subject to complex endo-, para-, and autocrine control mechanisms. In addition to insulin, thyroid hormones, sex steroids, and growth hormone (GH), components of the IGF system have been identified as key pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac20a1dccf62f2729bed2f1a0919f2c
https://www.arch-anim-breed.net/43/223/2000/
https://www.arch-anim-breed.net/43/223/2000/
Autor:
Andreas W. Kuss, Ildiko Racz, Lore Becker, Thomas Klopstock, Lillian Garrett, Lars R. Jensen, Markus Ralser, Jozef Gecz, Martin Hrabě de Angelis, Matthias Rath, Hans-Hilger Ropers, Martin Klingenspor, Eckhard Wolf, Juan Antonio Aguilar-Pimentel, Thure Adler, Wolfgang Wurst, Anke Van Dijck, Sabine Müller, Jan Rozman, Viola von Bohlen und Halbach, Andreas Zimmer, Kristin Moreth, Harry Scherthan, Katharina Blümlein, Martin B. Delatycki, Birgit Rathkolb, Diego J. Walther, Jochen Graw, R. Frank Kooy, Jerzy Adamski, Valerie Gailus-Durner, Oliver Puk, Helmut Fuchs, Sabine M. Hölter, Bettina Bert, Oliver von Bohlen und Halbach, Cornelia Prehn, Wolfgang Hans, Zornitza Stark, Monika Dopatka, Dirk H. Busch, Heidrun Fink
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Biochimica et biophysica acta : molecular basis of disease
Biochimica et biophysica acta / Molecular basis of disease 1865(9), 2083-2093 (2019). doi:10.1016/j.bbadis.2018.12.011
Biochimica et biophysica acta : molecular basis of disease
Biochimica et biophysica acta / Molecular basis of disease 1865(9), 2083-2093 (2019). doi:10.1016/j.bbadis.2018.12.011
Mutations in the X chromosomal tRNA 2'-O-methyltransferase FTSJ1 cause intellectual disability (ID). Although the gene is ubiquitously expressed affected individuals present no consistent clinical features beyond ID. In order to study the pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7c5352c82f2abde8ba3f3cd43a40d0
https://hdl.handle.net/21.11116/0000-0003-587A-221.11116/0000-0003-587C-0
https://hdl.handle.net/21.11116/0000-0003-587A-221.11116/0000-0003-587C-0