Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Bong-Jo Kim"'
Autor:
Jiwoo Lim, Jun Ho Yun, Kwangwoo Kim, So Young Bang, Eunji Ha, Bong Jo Kim, Jae Bum Bae, Hye Soon Lee, Jeongmin Kim, Sang Cheol Bae
Publikováno v:
Annals of the Rheumatic Diseases. 80:876-883
ObjectiveCD4+ T cells have been suggested as the most disease-relevant cell type in rheumatoid arthritis (RA) in which RA-risk non-coding variants exhibit allele-specific effects on regulation of RA-driving genes. This study aimed to understand RA-sp
Autor:
Takahiro Okawa, Hiroyuki Suetsugu, Tomoya Miyamura, So-Young Bang, Tomokazu Yoshioka, Yoshiya Tanaka, Akari Suzuki, Chikashi Terao, Koichi Amano, Takeshi Kuroda, Hiroaki Niiro, Koichi Matsuda, Bong-Jo Kim, Takashi Atsumi, Masaya Mukai, Tomomichi Kajino, Katsunori Ikari, Goro Motomura, Junichi Nakamura, Masaru Koido, Young-Chang Kwon, Yohei Naito, Yuta Kochi, Ayumi Kaneuji, G.Y. Ahn, Koichiro Ohmura, Yuji Yasunaga, Yeon-Kyung Lee, Kohei Karino, Ryo Hisada, Takuaki Yamamoto, Shiro Ikegawa, Mihoko Yamazaki, Kohei Tomizuka, Nobuhiko Sugano, Kenji Ohzono, Jihye Kim, Masato Shimizu, Takeshi Miyamoto, Sang Cheol Bae, Yoichi Ohta, Tsutomu Takeuchi, Tamon Kabata, Jung-Min Shin, Ken Yamaji, Kwangwoo Kim, Hye-Soon Lee, Taisuke Seki, Toshikazu Kubo, Yoshifumi Tada, Ji Soong Kim, Daisuke Takahashi, Yukinori Okada, Yuma Sakamoto, Dae Jin Park
Publikováno v:
Hum Mol Genet
Osteonecrosis of the femoral head (ONFH) involves necrosis of bone and bone marrow of the femoral head caused by ischemia with unknown etiology. Previous genetic studies on ONFH failed to produce consistent results, presumably because ONFH has variou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a55a2b99b9c715161809420905a02d5
https://europepmc.org/articles/PMC8976424/
https://europepmc.org/articles/PMC8976424/
Autor:
Bong-Jo Kim, Hyongbum Kim, Seokjoong Kim, Mi Yeong Hwang, Young-Jin Kim, Yun Kyoung Kim, Kwaku Dad Abu-Bonsrah, Eun-Seo Lee, Nathaniel S. Hwang, Sanghoon Moon
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 14, Iss, Pp 253-265 (2019)
Molecular Therapy: Oncolytics, Vol 14, Iss, Pp 253-265 (2019)
Here, we found two genomic safe harbor (GSH) candidates from chromosomes 3 and 8, based on large-scale population-based cohort data from 4,694 Koreans by CNV analysis. Furthermore, estimated genotype of these CNVRs was validated by quantitative real-
Autor:
Marju Orho-Melander, Humberto García-Ortiz, Xueling Sim, Amp-T D-Genes, Cheol Joo Park, Gina M. Peloso, Jason Flannick, Brian Tomlinson, Hyun Min Kang, Emilio J. Cordova, Stephen S. Rich, Richard A. Gibbs, Angélica Martínez-Hernández, Lorena Orozco, Harsha Doddapaneni, Lisa R. Yanek, Jiwon Lee, Namrata Gupta, Valeriya Lyssenko, Sohee Han, James B. Meigs, Bong-Jo Kim, Bruce M. Psaty, Leslie S. Emery, Kerrin S. Small, Pradeep Natarajan, May E. Montasser, Christian Gieger, Sharon L.R. Kardia, Sarah C. Nelson, Craig L. Hanis, Heikki A. Koistinen, María Elena González-Villalpando, Edmund Chan, Michael Y. Tsai, Benjamin Glaser, Thomas Meitinger, Matthew J. Bown, Mariaelisa Graff, John Danesh, Sekar Kathiresan, Tiinamaija Tuomi, Ramachandran S. Vasan, Gil Atzmon, Alyna T. Khan, Diego Ardissino, Yii-Der Ida Chen, David Zhang, Rob M. van Dam, Wendy S. Post, Barry I. Freedman, D. C. Rao, Michael Preuss, Donna M. Lehman, L. Adrienne Cupples, Colin N. A. Palmer, Claudia H. T. Tam, Hortensia Moreno-Macías, Markku Laakso, Peter Dornbos, Teresa Tusié-Luna, Stella Aslibekyan, Marguerite R. Irvin, Daniel J. Rader, Jee-Young Moon, Eimear E. Kenny, Lisa W. Martin, Jennifer A. Brody, Amit Khera, Erwin P. Bottinger, Sarah E. Graham, Myriam Fornage, Ruth McPherson, Nancy L. Heard-Costa, Michael Boehnke, Clicerio Gonzalez, Ryan W. Kim, Yi-Cheng Chang, Peter M. Nilsson, Yik Ying Teo, Robert Sladek, Cristen J. Willer, Fei Fei Wang, Donna K. Arnett, Mark Chaffin, Karine A. Viaud Martinez, Alanna C. Morrison, Leslie A. Lange, Ravindranath Duggirala, Donna M. Muzny, Kent D. Taylor, Niels Grarup, Soren Germer, Patricia A. Peyser, Brian E. Cade, Lewis C. Becker, Steven A. Lubitz, Nicholette D. Palmer, Susan K. Dutcher, Ronald C.W. Ma, Xuenan Mi, Xiuqing Guo, Hugh Watkins, Eric Boerwinkle, Qibin Qi, Johanna Kuusisto, Christie M. Ballantyne, Tanika N. Kelly, Rajiv Chowdhury, Elvia Mendoza-Caamal, Wing-Yee So, Tien Yin Wong, Torben Hansen, Cecilia Contreras-Cubas, Jeong-Sun Seo, Mi Yeong Hwang, Daekwan Seo, Dajiang J. Liu, Cristina Revilla-Monsalve, Paul S. de Vries, Daniel R. Witte, Yi-Jen Hung, Olle Melander, Karen L. Mohlke, Lucinda Antonacci-Fulton, Francisco Barajas-Olmos, Soo Heon Kwak, Daniel E. Weeks, Claudia Schurmann, Ginger A. Metcalf, Young-Jin Kim, Adrienne M. Stilp, Lori L. Bonnycastle, John Blangero, Ralph A. DeFronzo, Donald W. Bowden, Rasika A. Mathias, Oluf Pedersen, Rozenn N. Lemaitre, Stephen T. McGarvey, Heribert Schunkert, Jaakko Tuomilehto, Farook Thameem, Valentin Fuster, Joshua C. Bis, George Hindy, Allan Linneberg, James G. Wilson, Kyong Soo Park, Sergio A. Islas-Andrade, Ching-Yu Cheng, Won Jung Choi, Minxian X. Wang, Xuzhi Wang, Adolfo Correa, Jai G. Broome, Gail P. Jarvik, Alexander P. Reiner, E. Shyong Tai, Juyoung Lee, Mark I. McCarthy, Nilesh J. Samani, Susan Redline, Carlos A. Aguilar-Salinas, Jerome I. Rotter, Ma. Eugenia Garay-Sevilla, Jiang He, Patrick T. Ellinor, Joseph Park, Joanne E. Curran, Nir Barzilai, Federico Centeno-Cruz, Seonwook Lee, Lawrence F. Bielak, Jianjun Liu, Charles Kooperberg, Juan M. Peralta, Jose C. Florez, Leif Groop, Noël P. Burtt, Margaret Sunitha Selvaraj, Jeffrey R. O'Connell, Ruth J. F. Loos
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency170,000 individuals f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cffcbe73ed87d1953f10593c831399
https://doi.org/10.1101/2020.12.22.423783
https://doi.org/10.1101/2020.12.22.423783
Autor:
Anubha Mahajan, Cassandra N Spracklen, Weihua Zhang, Maggie CY Ng, Lauren E Petty, Hidetoshi Kitajima, Grace Z Yu, Sina Rüeger, Leo Speidel, Young Jin Kim, Momoko Horikoshi, Josep M Mercader, Daniel Taliun, Sanghoon Moon, Soo-Heon Kwak, Neil R Robertson, Nigel W Rayner, Marie Loh, Bong-Jo Kim, Joshua Chiou, Irene Miguel-Escalada, Pietro della Briotta Parolo, Kuang Lin, Fiona Bragg, Michael H Preuss, Fumihiko Takeuchi, Jana Nano, Xiuqing Guo, Amel Lamri, Masahiro Nakatochi, Robert A Scott, Jung-Jin Lee, Alicia Huerta-Chagoya, Mariaelisa Graff, Jin-Fang Chai, Esteban J Parra, Jie Yao, Lawrence F Bielak, Yasuharu Tabara, Yang Hai, Valgerdur Steinthorsdottir, James P Cook, Mart Kals, Niels Grarup, Ellen M Schmidt, Ian Pan, Tamar Sofer, Matthias Wuttke, Chloe Sarnowski, Christian Gieger, Darryl Nousome, Stella Trompet, Jirong Long, Meng Sun, Lin Tong, Wei-Min Chen, Meraj Ahmad, Raymond Noordam, Victor JY Lim, Claudia HT Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, Laura M Raffield, Cécile Lecoeur, Nisa M Maruthur, Bram Peter Prins, Aude Nicolas, Lisa R Yanek, Guanjie Chen, Richard A Jensen, Salman Tajuddin, Edmond Kabagambe, Ping An, Anny H Xiang, Hyeok Sun Choi, Brian E Cade, Jingyi Tan, Fernando Abaitua, Linda S Adair, Adebowale Adeyemo, Carlos A Aguilar-Salinas, Masato Akiyama, Sonia S Anand, Alain Bertoni, Zheng Bian, Jette Bork-Jensen, Ivan Brandslund, Jennifer A Brody, Chad M Brummett, Thomas A Buchanan, Mickaël Canouil, Juliana CN Chan, Li-Ching Chang, Miao-Li Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Mary Cushman, Swapan K Das, H. Janaka de Silva, George Dedoussis, Latchezar Dimitrov, Ayo P Doumatey, Shufa Du, Qing Duan, Kai-Uwe Eckardt, Leslie S Emery, Daniel S Evans, Michele K Evans, Krista Fischer, James S Floyd, Ian Ford, Myriam Fornage, Oscar H Franco, Timothy M Frayling, Barry I Freedman, Christian Fuchsberger, Pauline Genter, Hertzel C Gerstein, Vilmantas Giedraitis, Clicerio González-Villalpando, Maria Elena González-Villalpando, Mark O Goodarzi, Penny Gordon-Larsen, David Gorkin, Myron Gross, Yu Guo, Sophie Hackinger, Sohee Han, Andrew T Hattersley, Christian Herder, Annie-Green Howard, Willa Hsueh, Mengna Huang, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Mohammad Arfan Ikram, Martin Ingelsson, Md. Tariqul Islam, Masato Isono, Hye-Mi Jang, Farzana Jasmine, Guozhi Jiang, Jost B Jonas, Marit E Jørgensen, Torben Jørgensen, Yoichiro Kamatani, Fouad R Kandeel, Anuradhani Kasturiratne, Tomohiro Katsuya, Varinderpal Kaur, Takahisa Kawaguchi, Jacob M Keaton, Abel N Kho, Chiea-Chuen Khor, Muhammad G Kibriya, Duk-Hwan Kim, Katsuhiko Kohara, Jennifer Kriebel, Florian Kronenberg, Johanna Kuusisto, Kristi Läll, Leslie A Lange, Myung-Shik Lee, Nanette R Lee, Aaron Leong, Liming Li, Yun Li, Ruifang Li-Gao, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Adam E Locke, Tin Louie, Jian’an Luan, Andrea O Luk, Xi Luo, Jun Lv, Valeriya Lyssenko, Vasiliki Mamakou, K Radha Mani, Thomas Meitinger, Andres Metspalu, Andrew D Morris, Girish N. Nadkarni, Jerry L Nadler, Michael A Nalls, Uma Nayak, Ioanna Ntalla, Yukinori Okada, Lorena Orozco, Sanjay R Patel, Mark A Pereira, Annette Peters, Fraser J Pirie, Bianca Porneala, Gauri Prasad, Sebastian Preissl, Laura J Rasmussen-Torvik, Alexander P Reiner, Michael Roden, Rebecca Rohde, Katheryn Roll, Charumathi Sabanayagam, Maike Sander, Kevin Sandow, Naveed Sattar, Sebastian Schönherr, Claudia Schurmann, Mohammad Shahriar, Jinxiu Shi, Dong Mun Shin, Daniel Shriner, Jennifer A Smith, Wing Yee So, Alena Stančáková, Adrienne M Stilp, Konstantin Strauch, Ken Suzuki, Atsushi Takahashi, Kent D Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Brian Tomlinson, Jason M Torres, Fuu-Jen Tsai, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S Udler, Adan Valladares-Salgado, Rob M van Dam, Jan B van Klinken, Rohit Varma, Marijana Vujkovic, Niels Wacher-Rodarte, Ellie Wheeler, Eric A Whitsel, Ananda R Wickremasinghe, Konstantin Willems van Dijk, Daniel R Witte, Chittaranjan S Yajnik, Ken Yamamoto, Toshimasa Yamauchi, Loïc Yengo, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, Liang Zhang, Wei Zheng, null FinnGen, Leslie J Raffel, Michiya Igase, Eli Ipp, Susan Redline, Yoon Shin Cho, Lars Lind, Michael A Province, Craig L Hanis, Patricia A Peyser, Erik Ingelsson, Alan B Zonderman, Bruce M Psaty, Ya-Xing Wang, Charles N Rotimi, Diane M Becker, Fumihiko Matsuda, Yongmei Liu, Eleftheria Zeggini, Mitsuhiro Yokota, Stephen S Rich, Charles Kooperberg, James S Pankow, James C Engert, Yii-Der Ida Chen, Philippe Froguel, James G Wilson, Wayne HH Sheu, Sharon LR Kardia, Jer-Yuarn Wu, M Geoffrey Hayes, Ronald CW Ma, Tien-Yin Wong, Leif Groop, Dennis O Mook-Kanamori, Giriraj R Chandak, Francis S Collins, Dwaipayan Bharadwaj, Guillaume Paré, Michèle M Sale, Habibul Ahsan, Ayesha A Motala, Xiao-Ou Shu, Kyong-Soo Park, J Wouter Jukema, Miguel Cruz, Roberta McKean-Cowdin, Harald Grallert, Ching-Yu Cheng, Erwin P Bottinger, Abbas Dehghan, E-Shyong Tai, Josee Dupuis, Norihiro Kato, Markku Laakso, Anna Köttgen, Woon-Puay Koh, Colin NA Palmer, Simin Liu, Goncalo Abecasis, Jaspal S Kooner, Ruth JF Loos, Kari E North, Christopher A Haiman, Jose C Florez, Danish Saleheen, Torben Hansen, Oluf Pedersen, Reedik Mägi, Claudia Langenberg, Nicholas J Wareham, Shiro Maeda, Takashi Kadowaki, Juyoung Lee, Iona Y Millwood, Robin G Walters, Kari Stefansson, Simon R Myers, Jorge Ferrer, Kyle J Gaulton, James B Meigs, Karen L Mohlke, Anna L Gloyn, Donald W Bowden, Jennifer E Below, John C Chambers, Xueling Sim, Michael Boehnke, Jerome I Rotter, Mark I McCarthy, Andrew P Morris
We assembled an ancestrally diverse collection of genome-wide association studies of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). We identified 277 loci at genome-wide significance (p-8), including 237 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be91c56feb95ce8411ba72966d78fe8d
https://doi.org/10.1101/2020.09.22.20198937
https://doi.org/10.1101/2020.09.22.20198937
Autor:
Leilei Wen, Tomoya Miyamura, Xiaodong Zheng, So-Young Bang, Eunji Ha, Cheng-Xu Li, Sungsin Jo, Changbing Shen, Weiran Li, Yukinori Okada, Koichiro Ohmura, Shruti Eswar, Ken Yamaji, Sen Yang, Huihua Ding, Takayuki Sumida, Chang-Hee Suh, Seung-Cheol Shim, Yuta Kochi, Tae-Hwan Kim, Takuaki Yamamoto, Won Tae Chung, Yong Beom Park, Masaru Koido, John B. Harley, Goro Motomura, Yujun Sheng, G.Y. Ahn, Jung-Yoon Choe, Takeshi Miyamoto, Rui-Xue Leng, Xuejun Zhang, Takashi Atsumi, Chikashi Terao, Jung-Min Shin, Yoshifumi Tada, Xiaoting Chen, Young-Ho Park, Nobuhiko Sugano, He Huang, Keitaro Matsuo, Hiroaki Niiro, Hanan Salim, Leah C. Kottyan, Young Mo Kang, Masaya Mukai, Yong Cui, Junichi Nakamura, Young-Chang Kwon, Yeon-Kyung Lee, Minglong Cai, Sreeja Parameswaran, Wanling Yang, Kwangwoo Kim, Mi Yeong Hwang, Takeshi Kuroda, Masato Shimizu, Yasushi Kawaguchi, Xianyong Yin, Kyungheon Yoon, Daisuke Takahashi, Sang Cheol Bae, Keke Li, Hye-Soon Lee, Matthew T. Weirauch, Yuma Sakamoto, Nao Otomo, Tsutomu Takeuchi, Yuanjia Tang, Kohei Karino, Koichi Matsuda, Bong-Jo Kim, Shiro Ikegawa, Nan Shen, Wen-Min Fei, Hiroyuki Suetsugu, Lu Liu, Akari Suzuki, Dong-Qing Ye, Mengwei Wang, Kazuhiko Yamamoto, Yong-Fei Wang, Viktoryia Laurynenka, Shin-Seok Lee, Koichi Amano, Kazuyoshi Ishigaki
Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci1-8. Nevertheless, these loci only partially explain SLE heritability and provide limited biological insight. We report the largest stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7942117567ab64305a3bac6c7bfc6f9
https://doi.org/10.1101/2020.08.22.20178939
https://doi.org/10.1101/2020.08.22.20178939
Autor:
Jun Ho Yun, Nak-Hyeon Choi, Bong-Jo Kim, Jinhwa Kong, Song Cheol Kim, Hyo Jin Kim, Ho-Yeong Yu, Kibaick Lee, Sanghoon Moon, In-Uk Koh, Song Lee
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care
IntroductionObesity is growing global health concern and highly associated with increased risk of metabolic diseases including type 2 diabetes. We aimed to discover new differential DNA methylation patterns predisposing obesity and prioritize surroga
Autor:
Chien-Hsiun Chen, Anna L. Gloyn, Atsushi Takahashi, Sohee Han, Ken Suzuki, Mark A Pereira, Shi Jinxiu, Fiona Bragg, Yii-Der Ida Chen, Robin G. Walters, Takashi Kadowaki, Charumathi Sabanayagam, Annie-Green Howard, Mark I. McCarthy, Zheng Bian, Zhengming Chen, E-Shyong Tai, Chii-Min Hwu, Cassandra N. Spracklen, Yuan-Tsong Chen, Linda S. Adair, Momoko Horikoshi, Guozhi Jiang, Ching-Yu Cheng, Mi Yeong Hwang, Andrew P. Morris, Karen L. Mohlke, John C. Chambers, Jian-Min Yuan, Woon-Puay Koh, Hyeok Sun Choi, Ju Young Lee, Bong-Jo Kim, Masato Akiyama, Sahoko Ichihara, Xueling Sim, Norihiro Kato, Kuang Lin, Jirong Long, Xiuqing Guo, Fumihiko Takeuchi, Penny Gordon-Larsen, Hannah J Perrin, Young Jin Kim, Lee-Ming Chuang, Weihua Zhang, Rob M. van Dam, Andrea O.Y. Luk, Masahiro Nakatochi, Yukinori Okada, Katsuhiko Kohara, Yoichiro Kamatani, Jerome I. Rotter, Iona Y Millwood, Jer-Yuarn Wu, Canqing Yu, Wayne Huey-Herng Sheu, Shiro Maeda, Jost B. Jonas, Yasuharu Tabara, Mitsuhiro Yokota, Li-Ching Chang, Toshimasa Yamauchi, Shufa Du, Yu Guo, Yoon Shin Cho, Yi-Jen Hung, Jie Yao, Soo Heon Kwak, Hye-Mi Jang, Maggie C.Y. Ng, Xiao-Ou Shu, Myung-Shik Lee, Kyungheon Yoon, Sarah M Brotman, Sanghoon Moon, Tien Yin Wong, Martijn van de Bunt, Michiya Igase, Claudia H. T. Tam, Fumihiko Matsuda, Wei Zheng, Liang Zhang, Yong-Bing Xiang, Victor Jun Yu Lim, Ronald Cw Ma, Liming Li, Tomohiro Katsuya, Jianjun Liu, Jun Lv, Jennifer E. Below, Anubha Mahajan, Kyong-Soo Park, Masato Isono, Wing-Yee So, Nanette R. Lee, Brian Tomlinson, Juliana C.N. Chan, Lauren E. Petty, Chiea Chuen Khor, Miao-Li Chee, Ken Yamamoto, Wei Huang, Michael Boehnke, Jin-Fang Chai, Donald W. Bowden, Apoorva K Iyengar, Dong Mun Shin, Myron D. Gross, Takahisa Kawaguchi, Ya Xing Wang, Fuu Jen Tsai
Publikováno v:
Spracklen, C N, Horikoshi, M, Kim, Y J, Lin, K, Bragg, F, Moon, S, Suzuki, K, Tam, C H T, Tabara, Y, Kwak, S, Takeuchi, F, Long, J, Lim, V J Y, Chai, J, Chen, C, Nakatochi, M, Yao, J, Choi, H S, Iyengar, A K, Perrin, H J, Brotman, S M, Van De Bunt, M, Gloyn, A L, Below, J E, Boehnke, M, Bowden, D W, Chambers, J C, Mahajan, A, Mccarthy, M I, Ng, M C Y, Petty, L E, Zhang, W, Morris, A P, Adair, L S, Akiyama, M, Bian, Z, Chan, J C N, Chang, L, Chee, M, Chen, Y I, Chen, Y, Chen, Z, Chuang, L, Du, S, Gordon-larsen, P, Gross, M, Guo, X, Guo, Y, Han, S, Howard, A, Huang, W, Hung, Y, Hwang, M Y, Hwu, C, Ichihara, S, Isono, M, Jang, H, Jiang, G, Jonas, J B, Kamatani, Y, Katsuya, T, Kawaguchi, T, Khor, C, Kohara, K, Lee, M, Lee, N R, Li, L, Liu, J, Luk, A O, Lv, J, Okada, Y, Pereira, M A, Sabanayagam, C, Shi, J, Shin, D M, So, W Y, Takahashi, A, Tomlinson, B, Tsai, F, Van Dam, R M, Xiang, Y, Yamamoto, K, Yamauchi, T, Yoon, K, Yu, C, Yuan, J, Zhang, L, Zheng, W, Igase, M, Cho, Y S, Rotter, J I, Wang, Y, Sheu, W H H, Yokota, M, Wu, J, Cheng, C, Wong, T, Shu, X, Kato, N, Park, K, Tai, E, Matsuda, F, Koh, W, Ma, R C W, Maeda, S, Millwood, I Y, Lee, J, Kadowaki, T, Walters, R G, Kim, B, Mohlke, K L & Sim, X 2020, ' Identification of type 2 diabetes loci in 433,540 East Asian individuals ', Nature, vol. 582, no. 7811, pp. 240-245 . https://doi.org/10.1038/s41586-020-2263-3
Nature
Nature
SUMMARYMeta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9f9cbd13806bc109661a1ec4ed25e6
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-13 (2019)
Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-13 (2019)
Rheumatoid arthritis (RA) is a complex chronic systematic disease with progressive destruction of the joints by invasive synoviocytes. To characterize the key regulators involved in the development of RA, we obtained multilayer epigenomics data inclu
Autor:
Min Jin Go, Joo-Yeon Hwang, Juan E. Castillo-Fernandez, Bong-Jo Kim, Hyojung Lee, Tim D. Spector, Han Byul Jang, Hye-Ja Lee, Jordana T. Bell, Nak-Hyun Choi, Jae Bum Bae
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Genome-wide DNA methylation has been implicated in complex human diseases. Here, we identified epigenetic biomarkers for type 2 diabetes (T2D) underlying obesogenic environments. In a blood-based DNA methylation analysis of 11 monozygotic twins (MZTW