Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Minoru Takada"'
Autor:
Akihito Kubo, Yoko Kusunoki, Kazuhiro Asami, Minoru Takada, Masahiko Ando, Shojiro Minomo, Shinji Atagi, Yoji Ogawa, Kazutaka Uehira, Yoshinobu Matsuda, Kaoru Maruyama, Mari Ishii, Tomoya Kawaguchi, Masaki Kanazu
Publikováno v:
Clinical Lung Cancer. 15:182-187
Early prediction of therapeutic outcome is important in determining whether the ongoing therapy is beneficial. In addition to anatomical response determined using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria, recent studies have
Autor:
Adusa Moriyama, Koji Takeda, Kazuhiko Nakagawa, Naoko Sueoka-Aragane, Hiroshige Yoshioka, Kaoru Matsui, Masashi Kobayashi, Minoru Takada, Nobuyuki Katakami, Yasuo Iwamoto
Publikováno v:
Japanese Journal of Clinical Oncology. 41:948-952
OBJECTIVE Elderly patients prefer to receive less-toxic therapy. Monotherapy using drugs such as vinorelbine, gemcitabine or docetaxel is a preferable chemotherapy in elderly patients with advanced non-small-cell lung cancer. Gefitinib shows remarkab
Autor:
Tomoya Kawaguchi, Minoru Takada, Isamu Okamoto, Junya Fukuoka, Yasuhiro Koh, Yoko Kusunoki, Kazuhiko Nakagawa, Akihito Kubo, Masanori Kitaichi, Shun Ichi Isa
Publikováno v:
Internal Medicine. 50:745-748
Small molecule inhibitors targeting epidermal growth factor receptor (EGFR) are known to be active against non-small cell lung cancer (NSCLC) although the pharmacodynamics of these agents on malignant pleural effusion (MPE) remains unclear. Here we d
Autor:
Akihide Matsumura, Meinoshin Okumura, Haruhiro Yukiue, Masaaki Kawahara, Minoru Takada, Motoki Yano, Hidefumi Sasaki, Shigeki Shimizu, Tomoya Kawaguchi, Akihito Kubo, Katsuhiro Okuda, Osamu Kawano, Yoshitaka Fujii, Keiji Iuchi, Naoto Kitahara
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 135:313-318
It has been reported that the R497K polymorphism of the epidermal growth factor receptor (EGFR) gene has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. On other hand, EGFR gene mutations at kinase domain i
Autor:
Masaaki Kawahara, Motoki Yano, Keiji Iuchi, Katsuhiro Okuda, Naoto Kitahara, Katsuhiko Endo, Tomoya Kawaguchi, Hisaichi Tanaka, Hidefumi Sasaki, Minoru Takada, Akihide Matsumura, Yoshitaka Fujii, Tomoki Yokoyama, Haruhiro Yukiue, Osamu Kawano
Publikováno v:
Journal of Surgical Research. 148:260-263
Background Mutations of the epidermal growth factor receptor (EGFR) gene at kinase domain have been reported in non-small-cell lung cancer (NSCLC), and some common somatic mutations in EGFR have been examined for their ability to predict sensitivity
Autor:
Hidefumi Sasaki, Naoto Kitahara, Motoki Yano, Katsuhiro Okuda, Haruhiro Yukiue, Katsuhiko Endo, Hisaichi Tanaka, Yoshitaka Fujii, Minoru Takada, Keiji Iuchi, Tomoki Yokoyama, Masaaki Kawahara, Tomoya Kawaguchi, Akihide Matsumura, Osamu Kawano
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 134:569-577
To evaluate the epidermal growth factor receptor (EGFR) protein expression, gene mutations and amplification as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC) receiving gefitinib, we have performed fluorescence in
Publikováno v:
Journal of Thoracic Oncology. 1:398-402
The benefits established in efficacy trials, usually randomized, controlled trials conducted under highly controlled circumstances with maximized internal validity, can frequently not be demonstrated in clinical practice at the community level. Effec
Autor:
Hidefumi Sasaki, Shigeki Shimizu, Minoru Takada, Masaaki Kawahara, Hisaichi Tanaka, Hiroshi Haneda, Katsuhiko Endo, Motoki Yano, Keiji Iuchi, Akihide Matsumura, Yoshitaka Fujii, Eriko Suzuki, Yoshihiro Kobayashi
Publikováno v:
International Journal of Cancer. 118:180-184
Much evidence has accumulated that the epidermal growth factor receptor (EGFR) and its family members are strongly implicated in the development and progression of lung cancers. Somatic mutations of the EGFR gene were found in about 25–40% of Japan
Autor:
Masaki, Kanazu, Kaoru, Maruyama, Masahiko, Ando, Kazuhiro, Asami, Mari, Ishii, Kazutaka, Uehira, Shojiro, Minomo, Yoshinobu, Matsuda, Tomoya, Kawaguchi, Shinji, Atagi, Yoji, Ogawa, Yoko, Kusunoki, Minoru, Takada, Akihito, Kubo
Publikováno v:
Clinical lung cancer. 15(3)
Early prediction of therapeutic outcome is important in determining whether the ongoing therapy is beneficial. In addition to anatomical response determined using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria, recent studies have
Autor:
Satoshi Morita, Miyako Satouchi, Kazuhiko Nakagawa, Yasushi Yatabe, Hirohito Tada, Junji Tsurutani, Shinichi Toyooka, Takashi Seto, Masahiro Fukuoka, Eiji Shimizu, Isamu Okamoto, Nobuyuki Katakami, Kazuhiro Asami, Tomonori Hirashima, Hiroshi Saito, Tetsuya Mitsudomi, Hiroshige Yoshioka, Shinzoh Kudoh, Shunichi Negoro, Minoru Takada, Kazuhiko Shibata
Publikováno v:
The Lancet. Oncology. 11(2)
Patients with non-small-cell lung cancer harbouring mutations in the epidermal growth factor receptor (EGFR) gene respond well to the EGFR-specific tyrosine kinase inhibitor gefitinib. However, whether gefitinib is better than standard platinum doubl