Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Agnieszka Wozniak"'
Autor:
Bernd Kasper, Palma Dileo, Zsuzsanna Papai, Axelle Nzokirantevye, Antoine Italiano, Charlotte Benson, Katerina Kopeckova, Saskia Litière, Isabelle Vanden Bempt, Facundo Zaffaroni, Eva Wardelmann, A. Lecesne, Olivier Mir, Nasim Ali, Agnieszka Wozniak, Patrick Schöffski, Franka Menge, Sandrine Marreaud, Sophie Cousin, Jean-Yves Blay, Hans Gelderblom
Publikováno v:
European Journal of Cancer, 134, 62-74. ELSEVIER SCI LTD
Background Gastrointestinal stromal tumour (GIST) is commonly treated with tyrosine kinase inhibitors (TKIs), but most patients ultimately develop secondary resistance. Cabozantinib, a multi-targeted TKI inhibitor, has activity in patient-derived GIS
Autor:
Jasmien Wellens, Keith R. Mehalek, Harbir S. Dhillon, Agnieszka Wozniak, Sneha S. Patil, Aya Agha, Kathleen R. Makielski, Yemarshet K. Gebreyohannes, Areej A. Ali, Anette Duensing, Jessica L. Rausch, Maria Debiec-Rychter, Yanis Tolstov, Patrick Schöffski, Donna M. Lee
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The majority of gastrointestinal stromal tumors (GISTs) are driven by oncogenic KIT signaling and can therefore be effectively treated with the tyrosine kinase inhibitor (TKI) imatinib mesylate. However, most GISTs develop imatinib resistance through
Autor:
Olli Kallioniemi, Markku Varjosalo, Katherine Icay, John Patrick Mpindi, Olli Tynninen, Sampsa Hautaniemi, Agnieszka Wozniak, Astrid Murumägi, Evgeny Kulesskiy, Pirjo Laakkonen, Yemarshet K. Gebreyohannes, Maria Laaksonen, Rainer Lehtonen, Heikki Joensuu, Olli-Pekka Pulkka, Krister Wennerberg, Harri Sihto, Salla Keskitalo, Patrick Schöffski, Alejandra Cervera
Publikováno v:
Clinical Cancer Research. 25:1676-1687
Purpose: Gastrointestinal stromal tumor (GIST) is a common type of soft-tissue sarcoma. Imatinib, an inhibitor of KIT, platelet-derived growth factor receptor alpha (PDGFRA), and a few other tyrosine kinases, is highly effective for GIST, but advance
Autor:
Jasmien Cornillie, Madalina-Elena Zhai, Christoph Lengauer, Raf Sciot, Jasmien Wellens, Agnieszka Wozniak, Yemarshet K. Gebreyohannes, Ulla Vanleeuw, Maria Debiec-Rychter, Alexandra K. Gardino, Erica Evans, Patrick Schöffski
Publikováno v:
Clinical Cancer Research. 25:609-618
Purpose: Gastrointestinal stromal tumors (GIST) are commonly treated with tyrosine kinase inhibitors (TKI). The majority of patients with advanced GIST ultimately become resistant to TKI due to acquisition of secondary KIT mutations, whereas primary
Autor:
Marika Nespi, Elizabeth A. Burton, Gideon Bollag, Bernice Matusow, Raf Sciot, Guoxian Wu, Jasmien Wellens, Patrick Schöffski, Jasmien Cornillie, Maria Debiec-Rychter, Gaston Habets, Chao Zhang, Yemarshet K. Gebreyohannes, Jack Lin, Agnieszka Wozniak
Publikováno v:
Clinical and experimental medicine. 19(2)
The purpose of the present study was to investigate the in vitro and in vivo activity of PLX9486, a tyrosine kinase inhibitor (TKI) targeting both primary KIT exon 9 and 11 and secondary exon 17 and 18 mutations in gastrointestinal stromal tumors (GI
Publikováno v:
Expert review of anticancer therapy. 17(12)
The majority of gastrointestinal stromal tumors (GIST) are driven by an abnormal receptor tyrosine kinase (RTK) signaling, occurring mainly due to somatic mutations in KIT or platelet derived growth factor receptor alpha (PDGFRA). Although the introd
Autor:
Janusz Limon, Eva Wardelmann, Elżbieta Bylina, Maria Debiec-Rychter, Patrick Schöffski, Piotr Rutkowski, Isabelle Hostein, Jean-Yves Blay, Agnieszka Wozniak, Isabelle Ray-Coquard, Raf Sciot, Jean-Michel Coindre, Axel Le Cesne, Janusz A. Siedlecki, Hans-Ulrich Schildhaus
Publikováno v:
Clinical Cancer Research. 20:6105-6116
Purpose: Although the mutational status in gastrointestinal stromal tumors (GIST) can predict the response to treatment with tyrosine kinase inhibitors, the role of tumor genotype as a prognostic factor remains controversial. The ConticaGIST study so
Autor:
Paul W. Manley, Jonathan A. Fletcher, Raf Sciot, Patrick Schöffski, Ulla Vanleeuw, Maria Debiec-Rychter, Thomas Van Looy, Haifu Li, Giuseppe Floris, Agnieszka Wozniak, Jasmien Wellens
Publikováno v:
Clinical Cancer Research. 20:6071-6082
Introduction: The PI3K signaling pathway drives tumor cell proliferation and survival in gastrointestinal stromal tumor (GIST). We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-derived GIST xenograft models. Experimental Des
Autor:
Patrick Schöffski, Vanessa Vanspauwen, Thomas Van Looy, Anna Quattrone, Agnieszka Wozniak, Piotr Rutkowski, Giuseppe Floris, Raf Sciot, Barbara Dewaele, Maria Debiec-Rychter
Publikováno v:
Modern Pathology. 27:1510-1520
Insufficiency of phosphatase and tensin homolog (PTEN) occurs in numerous tumor types and has been implicated as a resistance mechanism to receptor tyrosine kinase-targeted therapies in human cancer. In this study, we have performed a comprehensive m
Autor:
Erik A.C. Wiemer, Patrick Schöffski, Antonius W. M. Boersma, Stefan Sleijfer, Caroline M.M. Gits, Ron H.J. Mathijssen, Moniek B E Jonkers, W F J van IJcken, Agnieszka Wozniak, Piotr Rutkowski, P F van Kuijk, Raf Sciot, Jaap Verweij, Takahiro Taguchi, Maria Debiec-Rychter
Publikováno v:
British Journal of Cancer, 109(6), 1625-1635. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer
BACKGROUND: Gastrointestinal stromal tumours (GIST) are characterised by high expression of KIT and ETV1, which cooperate in GIST oncogenesis. Our aim was to identify microRNAs that are deregulated in GIST, have a role in GIST pathogenesis, and could