Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gaojie Song"'
Autor:
Yueming Xu, Yang Wang, Gaojie Song, Deqiang Yao, Yao Peng, Kaiwen Liu, Houchao Tao, Yuxia Wang, Haiguang Liu
Publikováno v:
IUCrJ
IUCrJ, Vol 6, Iss 6, Pp 996-1006 (2019)
IUCrJ, Vol 6, Iss 6, Pp 996-1006 (2019)
The ∼100 mutations used during the structural determination of GLP-1R suggest multiple mutagenesis strategies, which may find applications in the crystallization of G-protein-coupled receptors and other membrane proteins, and potentially in functio
Autor:
Victor May, Karen M. Braas, David Chatenet, Chenyi Liao, Gaojie Song, Severin T. Schneebeli, Matthias Brewer, Jianing Li, Mathilde Poujol de Molliens
Publikováno v:
Current Topics in Medicinal Chemistry. 19:1399-1417
The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to
Previously we reported a common activation pathway of the class A G protein-coupled receptors (GPCRs) in which a series of conserved residues/motifs undergo conformational change during extracellular agonist binding and finally induce the coupling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1161f9e6a8086ef9b8e6fe31b33b29d
https://doi.org/10.1101/2021.09.08.459393
https://doi.org/10.1101/2021.09.08.459393
Autor:
Yan Lu, Antao Dai, Gaojie Song, Qingtong Zhou, Wenwen Bai, Zhi-Jie Liu, Shanshan Qin, Dehua Yang, Raymond C. Stevens, Wenqing Shui, John D. McCorvy, Michael A. Hanson, Suwen Zhao, Ming-Wei Wang, Mengmeng Meng, Bryan L. Roth, Xi Ping Huang, Yao Peng, Xiaoqing Cai, Yiran Wu
Publikováno v:
Chemical Science. 9:3192-3199
G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins and thus constitute an important family of therapeutic targets. Therefore, significant effort has been put towards the identification of novel ligands that can m
Autor:
Venkatasubramanian Dharmarajan, Anna Qiao, Xiaoai Wu, Guangyao Lin, Raymond G. Sierra, Michael A. Hanson, Patrick R. Griffin, Gye Won Han, Thomas D. Grant, Hui Zhang, Yanhong Wu, Steffen Reedtz-Runge, Linlin Yang, Haonan Zhang, Dehua Yang, Ming-Wei Wang, Wei Liu, Hualiang Jiang, Huaiyu Yang, Garrett Nelson, Xiaoqing Cai, Yuhui Dong, Raymond C. Stevens, Beili Wu, Antao Dai, Vadim Cherezov, Zhi Geng, Uwe Weierstall, Gaojie Song, Chris de Graaf, Limin Ma, Qiang Zhao, Jesper Lau
Publikováno v:
Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G W, Grant, T D, Sierra, R G, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P R, Lau, J, Cherezov, V, Yang, H, Hanson, M A, Stevens, R C, Zhao, Q, Jiang, H, Wang, M W & Wu, B 2017, ' Structure of the full-length glucagon class B G-protein-coupled receptor ', Nature, vol. 546, no. 7657, pp. 259-264 . https://doi.org/10.1038/nature22363
Nature
Nature, 546(7657), 259-264. Nature Publishing Group
Nature
Nature, 546(7657), 259-264. Nature Publishing Group
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes. Here we report the 3.0 Å crystal structure of full-length GCGR contai
Autor:
Gaojie Song, Jie Yang, Shengzhao Xu, Na Li, Minghui Niu, Deqiang Yao, Jie Yan, Guisheng Zhong
Publikováno v:
The Journal of Biological Chemistry
The adhesion G protein–coupled receptor CD97 and its ligand complement decay-accelerating factor CD55 are important binding partners in the human immune system. Dysfunction in this binding has been linked to immune disorders such as multiple sclero
Autor:
Qiang Zhao, Beili Wu, Raymond C. Stevens, Ming-Wei Wang, Chris de Graaf, Can Cao, Gaojie Song
Publikováno v:
de Graaf, C, Song, G, Cao, C, Zhao, Q, Wang, M W, Wu, B & Stevens, R C 2017, ' Extending the Structural View of Class B GPCRs ', Trends in Biochemical Sciences, vol. 42, no. 12, pp. 946-960 . https://doi.org/10.1016/j.tibs.2017.10.003
The secretin-like class B family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis. Recent structures of various receptors in complex with a variety of orthosteric and allosteric ligands provide fundamental new insights i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715cb94002c531a6c951cecadc0c063d
https://research.vu.nl/en/publications/6feaaea4-de0e-457c-a139-63db7156ace5
https://research.vu.nl/en/publications/6feaaea4-de0e-457c-a139-63db7156ace5
Autor:
Yiran Wu, Beili Wu, Gye Won Han, Zhi-Jie Liu, Yuxia Wang, Kaiwen Liu, Li Ye, Raymond C. Stevens, Chris de Graaf, Ming-Wei Wang, Jesper Lau, Qingtong Zhou, Dehua Yang, Fan Wu, Michael A. Hanson, Gaojie Song, Shanshan Jiang, Dongsheng Liu, Guangyao Lin, Suwen Zhao, Antao Dai, Xiaoqing Cai
Publikováno v:
Song, G, Yang, D, Wang, Y, de Graaf, C, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G W, Lau, J, Wu, B, Hanson, M A, Liu, Z J, Wang, M W & Stevens, R C 2017, ' Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators ', Nature, vol. 546, no. 7657, pp. 312-315 . https://doi.org/10.1038/nature22378
Nature, 546(7657), 312-315. Nature Publishing Group
Nature, 546(7657), 312-315. Nature Publishing Group
The glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have opposing physiological roles in insulin release and glucose homeostasis. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c948ad6ed96d74e6213b9eac0485fd
https://hdl.handle.net/1871.1/1de8330f-3650-451c-8d85-a44e91b04010
https://hdl.handle.net/1871.1/1de8330f-3650-451c-8d85-a44e91b04010
Publikováno v:
Journal of molecular biology. 429(17)
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are important human drug targets. Of the 826 human GPCRs, 118 of them recognize endogenous peptide or protein ligands, and 30 of the 118 are targeted by approved
Autor:
Huaiyu Yang, Wei Huang, Min Zhang, Kai-wen Liu, Yang Yang, Xiao-fang Liu, Zhi-Jie Liu, Shan-mei Cheng, Linlin Yang, Yubo Tang, Liyun Yang, Yechun Xu, Gaojie Song, Minjia Tan
Publikováno v:
Acta pharmacologica Sinica. 38(1)
CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a splicing variant of CD97 that recognizes