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pro vyhledávání: '"Leiliang Zhang"'
Palmitoylation of SARS‐CoV‐2 S protein is critical for S‐mediated syncytia formation and virus entry
Publikováno v:
Journal of Medical Virology
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the cause of the ongoing coronavirus disease 2019 (COVID‐19) pandemic. The S protein is the key viral protein for associating with ACE2, the receptor for SARS‐CoV‐2. There are
Publikováno v:
Biochemical and Biophysical Research Communications
SARS-CoV-2 papain-like protease is considered as an important potential target for anti-SARS-CoV-2 drug discovery due to its crucial roles in viral spread and innate immunity. Here, we have utilized an in silico molecular docking approach to identify
Publikováno v:
Biochemical and Biophysical Research Communications
SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found t
Publikováno v:
Journal of Medical Virology
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes the recent COVID‐19 public health crisis. Bat is the widely believed original host of SARS‐CoV‐2. However, its intermediate host before transmitting to humans is not clear.
Autor:
Haoran Cui, Leiliang Zhang
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology, Vol 11 (2021)
SARS-CoV-2 causes the ongoing COVID-19 pandemic. Natural SARS-COV-2 infection has been detected in dogs, cats and tigers. However, the symptoms in canines and felines were mild. The underlying mechanisms are unknown. Excessive activation of inflammas
Autor:
Zhiqiang Wu, Ruixuan Guo, Ting Chen, Jiaxin Hu, Yelin Han, Jianwei Wang, Xiuyuan Ou, Qi Jin, Zhewei Cui, Yintgtao Zhang, Xinquan Wang, Dan Mi, Pei Li, Zhaohui Qian, Zhixia Mu, Leiliang Zhang, Yan Liu
Bat coronavirus (CoV) RaTG13 shares the highest genome sequence identity with SARS-CoV-2 among all known coronaviruses, and also uses human angiotensin converting enzyme 2 (hACE2) for virus entry. Thus, SARS-CoV-2 is thought to have originated from b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe1b3602782fd92e7d2b0f9b4b3354a4
https://doi.org/10.1101/2020.11.16.385849
https://doi.org/10.1101/2020.11.16.385849
Autor:
Leiliang Zhang, Shan Gao
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 4040-4047 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 4040-4047 (2020)
Graphical abstract
Highlights • Association of ACE2 with S is the molecular determinant of SARS-CoV-2 infection. • Diversify in ACE2 leads to differences in SARS-CoV-2 infection outcomes. • The host range SARS-CoV-2 is dependent on the ACE
Highlights • Association of ACE2 with S is the molecular determinant of SARS-CoV-2 infection. • Diversify in ACE2 leads to differences in SARS-CoV-2 infection outcomes. • The host range SARS-CoV-2 is dependent on the ACE
Autor:
Haoran Cui, Leiliang Zhang
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Frontiers in Microbiology
Frontiers in Microbiology
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is one of seven human coronaviruses. G-quadruplexes are intrinsic obstacles to genome replication. Whether G-quad
Publikováno v:
Transboundary and Emerging Diseases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2. In our current study, we found that two ty