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pro vyhledávání: '"Terrence L. Geiger"'
Publikováno v:
European Journal of Immunology. 43:1195-1207
The fate of Foxp3(+) regulatory T (Treg) cells responding during autoimmunity is not well defined. We observed a marked elevation in KLRG1(+) (where KLRG1 stands for killer cell lectin-like receptor G1) CNS-infiltrating Treg cells in experimental aut
Autor:
Jing Ma, Cheng Cheng, Wei Liu, Jean N. Manirarora, Phuong Nguyen, Terrence L. Geiger, Xin Liu
Publikováno v:
The Journal of Immunology. 185:3895-3904
Regulatory T lymphocytes (Tregs) expressing the Foxp3 transcription factor are critical modulators of autoimmunity. Foxp3+ Tregs may develop in the thymus as a population distinct from conventional Foxp3− αβ T cells (Tconvs). Alternatively, plast
Autor:
Terrence L. Geiger, Ramesh K. Selvaraj
Publikováno v:
The Journal of Immunology. 180:2830-2838
Stimulation of naive T lymphocytes in the presence of IL-2 and TGF-β induces the regulatory transcription factor Foxp3, which endows the cells with regulatory functions. To better understand the properties and therapeutic potential of these induced
Autor:
Wei Du, Fengjuan Tang, Jian Peng, F. Susan Wong, Bridget Dicker, Li Wen, Terrence L. Geiger, Phuong Nguyen
Publikováno v:
Journal of Autoimmunity. 28:188-200
Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect o
Autor:
Terrence L. Geiger, Joshua F. Heiber
Publikováno v:
Cellular immunology. 279(1)
Circulating Foxp3(+) regulatory T cells (Treg) may arise in the thymus (natural Treg, nTreg) or through the adaptive upregulation of Foxp3 after T cell activation (induced Treg, iTreg). In this brief review, we explore evidence for the formation and
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(11)
Whereas increased affinity enhances T cell competitiveness after immunization, the role of affinity in modulating the pathogenicity of self-reactive T cells is less established. To assess this, we generated two myelin-specific, class II MHC-restricte
Autor:
Sharyn Tauro, Terrence L. Geiger
Publikováno v:
Human immunology. 73(3)
Foxp3(+) regulatory T lymphocytes (Treg) are critical homeostatic regulators of immune and inflammatory responses. Their absence leads to fulminant multiorgan autoimmunity. This review explores recent studies that have altered our emerging view of th
Autor:
Jing Ma, Xin Liu, Terrence L. Geiger, Phuong Nguyen, Wei Liu, Meredith Steeves, Cheng Cheng, John C. Obenauer
Summary The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3) + regulatory T (Treg) and conventional T (Tconv) cell populations active at sites of autoimmune pathology are not well characterized. To evaluate this,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b787fc2c815f6b4a0eb5c375f06150
https://europepmc.org/articles/PMC2878844/
https://europepmc.org/articles/PMC2878844/
Autor:
Ramesh K. Selvaraj, Terrence L. Geiger
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(12)
TGF-β induces Foxp3 expression in stimulated T cells. These Foxp3+ cells (induced regulatory T cells (iTreg)) share functional and therapeutic properties with thymic-derived Foxp3+ regulatory T cells (natural regulatory T cells (nTreg)). We performe
Autor:
Terrence L. Geiger
Publikováno v:
Blood. 119:3373-3374
In this issue of Blood , Plesa et al demonstrate that human Foxp3+ regulatory T cells can be redirected using MHC class I–restricted T-cell receptors (TCRs), showing a surprising lack of correlation of TCR affinity and their suppressive potency.[1]