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of 6
pro vyhledávání: '"Rebecca A. Haeusler"'
Autor:
Carrie L. Welch, Matthew Pratt-Hyatt, Curtis D. Klaassen, Rebecca A. Haeusler, Domenico Accili
Publikováno v:
Cell Metabolism. 15(1):65-74
SummaryThe association of type 2 diabetes with elevated plasma triglyceride (TG) and very low-density lipoproteins (VLDL), and intrahepatic lipid accumulation represents a pathophysiological enigma and an unmet therapeutic challenge. Here, we uncover
Publikováno v:
Journal of Biological Chemistry. 285:35245-35248
Hepatic glucose production (HGP) plays a vital role in maintaining the supply of glucose to the body, and transcription factor FoxO1 is known to confer hormone responsiveness onto HGP. Mice with a liver-specific FoxO1 deletion (L-FoxO1) show reduced
Publikováno v:
Journal of Biological Chemistry. 285:26861-26868
Patients with diabetes suffer disproportionately from impaired lipid metabolism and cardiovascular disease, but the relevant roles of insulin resistance and hyperglycemia in these processes are unclear. Transcription factor FoxO1 is regulated dually
Autor:
Fanny Langlet, Christoph Buettner, Daniel Lindén, Kumiko S. Aizawa, Domenico Accili, Ling Wang, Rebecca A. Haeusler, Elke Ericson, Anders Johansson, Joshua R. Cook, Tyrrell Norris
Publikováno v:
Cell. 171:824-835.e18
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight c
Autor:
Roger Gutierrez-Juarez, Joshua R. Cook, Mark A. Febbraio, Kirsten Hartil, Rebecca A. Haeusler, Irwin J. Kurland, Isabel Arrieta-Cruz, Helene L. Kammoun, Domenico Accili, Colette M. Knight, Bhavapriya Vaitheesvaran
Publikováno v:
Nature communications
Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former are low and the latter are exaggerated, posing a pathophysiologic and therapeutic conundrum
Autor:
Rebecca A. Haeusler, Domenico Accili
Publikováno v:
Cell Metabolism. (1):7-9
The Forkhead transcription factor Foxo1 regulates expression of genes involved in stress resistance and metabolism. To assess the contribution of Foxo1 to metabolic dysregulation during hepatic insulin resistance, we disrupted Foxo1 expression in the