Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Richard A, Koup"'
Autor:
Constantinos Petrovas, Richard A. Koup, Guillaume Stewart-Jones, Jorge R. Almeida, Sarah Rowland-Jones, Assan Jaye, David Wolinsky, Samuel Darko, Eirini Moysi, Daniel C. Douek, Ester Gea-Mallorquí, Yanchun Peng, Tao Dong
Publikováno v:
European journal of immunologyReferences. 51(10)
The dynamics of T-cell receptor (TCR) selection in chronic HIV-1 infection, and its association with clinical outcome, is well documented for an array of MHC-peptide complexes and disease stages. However, the factors that may contribute to the select
Autor:
Aurélie Ploquin, Karin Loré, Gustaf Lindgren, José DelaO Hernández, Daphne A. Stanley, Hugues Fausther-Bovendo, Frank Liang, Richard A. Koup, Aiala Salvador Martinez, Nancy J. Sullivan, Jason M. Brenchley
Publikováno v:
Journal of Immunological Methods. 425:69-78
The majority of vaccines and several treatments are administered by intramuscular injection. The aim is to engage and activate immune cells, although they are rare in normal skeletal muscle. The phenotype and function of resident as well as infiltrat
Autor:
Rajendra Pahwa, Varghese K. George, David Huddleston, David R. Ambrozak, Suresh Pallikkuth, Lesley R. de Armas, Savita Pahwa, Louis Gonzalez, Richard A. Koup, Constantinos Petrovas, Eirini Moysi
Publikováno v:
The Journal of clinical investigation. 128(7)
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral the
Autor:
Richard A. Koup, Patrick Younan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Michael G. Katze, Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
PLoS Pathogens
PLoS Pathogens
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however
Autor:
Marlous L. Grijsen, John R. Mascola, Rebecca M. Lynch, Adam K. Wheatley, Jan M. Prins, Richard A. Koup, Madhu Prabhakaran, Godelieve J. de Bree, Adrian B. McDermott, Stephen D. Schmidt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
Background Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie
Autor:
Constantinos Petrovas, Manuel Leal, Rafael Luque, Diane V. Havlir, Kapil K. Saharia, Prudence Ive, Sara Ferrando-Martinez, Richard A. Koup, Anne F Luetkemeyer
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
[Background] Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d152ab4f9f6ccd7b0e32861f3e7c455
https://hdl.handle.net/10668/10229
https://hdl.handle.net/10668/10229
Autor:
Brigitte Autran, Rémi Cheynier, Yin Xu, Adrien Six, Arnaud Moris, Angeline Rouers, Lucie Colineau, Assia Samri, Alejandra Urrutia, Takuya Yamamoto, Anthony D. Kelleher, Stéphanie Graff-Dubois, Richard A. Koup, Sylvain Cardinaud, Karim Dorgham, Pierre-Grégoire Coulon, Anne Hosmalin, Eric Oksenhendler, John Zaunders, Hang-Phuong Pham
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
International audience; Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b99955d4a70eff404e532fbe2a1260
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
Autor:
Eirini Moysi, Takuya Yamamoto, Robert Paris, Constantinos Petrovas, Sara Ferrando-Martinez, Kristin L. Boswell, Richard Haubrich, Eva Archer, David R. Ambrozak, Mark Connors, Joseph P. Casazza, Richard A. Koup, Julie A Ake, Jerome H. Kim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
The role of PD-1 expression on CD4 T cells during HIV infection is not well understood. Here, we describe the differential expression of PD-1 in CD127high CD4 T cells within the early/intermediate differentiated (EI) (CD27highCD45RAlow) T cell popula
Autor:
Gunilla B. Karlsson Hedestam, Jason G. D. Gall, Richard A. Koup, Cornelia Gujer, Karin Loré, Constantinos Petrovas, William C. Adams, Gerald M. McInerney
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7499-7504
Recombinant adenoviruses (rAds) based on types 5 (rAd5) and 35 (rAd35) have emerged as important vaccine delivery vectors in clinical testing for a variety of pathogens. A major difference between these vectors is their binding to cellular receptors
Autor:
Li Li, Yan-Ying Fan, Richard A. Koup, Tao Yu, Zi-Tong Huang, Robert T. Bailer, Man-Hui Wu, Chang-You Wu
Publikováno v:
Archives of Virology
SARS-CoV infection of human results in antigen-specific cellular and humoral immune responses. However, it is critical to determine whether SARS-CoV-specific memory T cells can persist for long periods of time. In this study, we analyzed the cellular