Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Xiaobin Han"'
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/α-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism. The objective of this review is to discuss the emer
Externí odkaz:
https://doaj.org/article/d92db2faec69428a8932927b277d5376
Publikováno v:
J Mol Cell Cardiol
There is controversy regarding whether excess FGF23 causes left ventricular hypertrophy (LVH) directly through activation of fibroblast growth factor receptor 4 (FGFR4) in cardiomyocytes or indirectly through reductions in soluble Klotho (sK). We inv
Autor:
Leigh Darryl Quarles, Xiaobin Han
Publikováno v:
Current Opinion in Nephrology and Hypertension. 25:333-342
This review examines the role of fibroblast growth factor-23 (FGF-23) in mineral metabolism, innate immunity and adverse cardiovascular outcomes.FGF-23, produced by osteocytes in bone, activates FGFR/α-Klotho (α-Kl) complexes in the kidney. The res
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Autor:
Benjamin Armstrong, Yuanjian Chen, Yao Sun, Xiaobin Han, Xue Liu, Ruisong Ye, L. Darryl Quarles, Min Pi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Both the activation of the renin angiotensin aldosterone system (RAAS) and elevations of circulating Fibroblast Growth Factor-23 (FGF-23) have been implicated in the pathogenesis of left ventricular hypertrophy (LVH) in chronic kidney disease. To inv
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Frontiers in Endocrinology
Frontiers in Endocrinology
Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/α-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism. The objective of this review is to discuss the emer
Autor:
Xiaobin Han, L. Darryl Quarles
Publikováno v:
Endocrinology. 159:3655-3656
Serum levels of fibroblast growth factor 23 (FGF23) markedly increase with renal impairment, with FGF23 levels correlating with the presence of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD). FGF23 acti
Autor:
Xiaobin Han, Gwendalyn D. King, Ganesh Kolumam, Jed Ross, Junichiro Sonoda, L. Darryl Quarles, Min Pi
Publikováno v:
Journal of the American Society of Nephrology : JASN. 29(1)
The bone-derived hormone fibroblast growth factor-23 (FGF-23) activates complexes composed of FGF receptors (FGFRs), including FGFR1, and α-Klotho in the kidney distal tubule (DT), leading to increased sodium retention and hypertension. However, the
Publikováno v:
Endocrinology. 154:4469-4482
Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone. To better understand the regulation of FGF-23 by calcium, phosphorus, 1,25 dihydroxyvitamin D3 [1,25(OH)2D],
Fibroblastic growth factor receptor 1 (FGFR1) signaling pathways are implicated in the regulation of FGF-23 gene transcription, but the molecular pathways remain poorly defined. We used low molecular weight (LMW, 18 kDa) FGF-2 and high molecular weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620a9af480a23cc6687d6796b072dcb8
https://europepmc.org/articles/PMC4400353/
https://europepmc.org/articles/PMC4400353/