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Autor:
Vineta Fellman, Robert B. Flint, Swantje Völler, Catherijne A. J. Knibbe, Yunjiao Wu, Karel Allegaert, Sinno H.P. Simons
Publikováno v:
Clinical Pharmacokinetics, 61(3), 401-412. Adis
Clinical Pharmacokinetics, 61, 401-412
Clinical Pharmacokinetics, 61, 401-412
BACKGROUND AND OBJECTIVE: Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on bodyweight. Given the limited pharmacokinetic information across the entire neonatal age ran
Autor:
Kuniaki Otaka, Shigeki Yamaguchi, Koji Okawa, Eiso Hiyama, Fumitaka Hashimoto, Takaaki Terahara
Publikováno v:
Clinical Drug Investigation. 41:1087-1098
Transdermal fentanyl is not yet approved for pediatric and adolescent use in Japan. Serum fentanyl concentration and the safety and efficacy of once-a-day fentanyl citrate patch were investigated in pediatric and adolescent patients with cancer pain.
Publikováno v:
Psychopharmacology
Background Illicitly manufactured fentanyl and its analogs are a major driving force behind the ongoing opioid crisis. Cyclopropylfentanyl is a fentanyl analog associated with many overdose deaths, but limited knowledge is available about its pharmac
Publikováno v:
МЕДИЦИНА НЕВІДКЛАДНИХ СТАНІВ; Том 16, № 6 (2020); 89-95
МЕДИЦИНА НЕОТЛОЖНЫХ СОСТОЯНИЙ; Том 16, № 6 (2020); 89-95
EMERGENCY MEDICINE; Том 16, № 6 (2020); 89-95
МЕДИЦИНА НЕОТЛОЖНЫХ СОСТОЯНИЙ; Том 16, № 6 (2020); 89-95
EMERGENCY MEDICINE; Том 16, № 6 (2020); 89-95
Background. Anesthesiology has already become multidisciplinary science and acquires more features of perioperative medicine. Confirmation of this is the development and implementation of Enhanced Recovery after Surgery (ERAS) protocols in various
Autor:
Thomas Stoehr, Frank Schippers, Laura Curd, Natalie Delpratt, Virginia D. Schmith, Jie Zhou, Lauren R. L. Lohmer, Joachim Ossig
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1554-1565 (2021)
Clinical and Translational Science
Clinical and Translational Science
The clinical effects of remimazolam (an investigational, ultra‐short acting benzodiazepine being studied in procedural sedation) were measured using the Modified Observer’s Assessment of Awareness/Sedation Scale (MOAA/S). The objective of this an
Autor:
Rami Tadros, Lorraine Mackenzie, Michael D. Wiese, Patrick Russell, Craig Phillips, Aymen Ali Al-Qurain, Richard N. Upton, Michael S. Roberts, Desmond B. Williams
Publikováno v:
European Journal of Clinical Pharmacology. 77:1357-1368
Purpose Subcutaneous fentanyl injection is commonly prescribed to manage acute pain in older patients; however, there is a gap in the literature describing the pharmacokinetic parameters for this route of administration in this population. The aim of
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:359-369
Fentanyl pharmacokinetic and pharmacodynamic data are limited in mechanically ventilated children. This study aimed to assess the fentanyl pharmacokinetics (PK), the sedation outcome, and the development of tolerance in children receiving fentanyl co
Autor:
Benjamin M. Brainard, Jane E. Quandt, Heather Skrzypczak, Rachel A. Reed, Daniel Sakai, Melanie Ruch, Carly Smyth, Michele Barletta, Heather K Knych
Publikováno v:
Equine Veterinary Journal. 54:153-158
Background Matrix fentanyl patches have not been investigated in horses and may represent an effective means of providing analgesia over an extended time period without venous catheterisation. Objectives To describe the pharmacokinetics of a matrix t
Autor:
Paweł Sobczyński, Paweł Wiczling, Agnieszka Bienert, Katarzyna Młodawska, Edmund Grześkowiak, Roma Hartmann-Sobczyńska
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
Cardiac output (CO) is expected to affect elimination and distribution of highly extracted and perfusion rate-limited drugs. This work was undertaken to quantify the effect of CO measured by the pulse pressure method on pharmacokinetics and pharmacod
Autor:
Henriikka Hakomäki, Merja Kokki, Terhi Puhto, Michael Spalding, Seppo Alahuhta, Merja Vakkala, Teemu Gunnar
Publikováno v:
European Journal of Clinical Pharmacology
Introduction Epidural hydromorphone could be useful in obstetric analgesia as there is a need for a more water-soluble opioid than sufentanil or fentanyl with prolonged analgesic effect. To our knowledge, the pharmacokinetics of epidural hydromorphon