Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yong-Chen Lu"'
Autor:
Lori McIntyre, Yong-Chen Lu, Liqiang Xi, Richard A. Morgan, Steven A. Feldman, Stephanie L. Goff, Parisa Malekzadeh, Lily Lu, Howard A. Fine, Richard M. Sherry, Nicholas P. Restifo, Monica Epstein, Zhili Zheng, Paul F. Robbins, Mark Raffeld, James Chih-Hsin Yang, Steven A. Rosenberg
Publikováno v:
J Immunother
A deletion variant of epidermal growth factor receptor (EGFRvIII) is a known driver mutation in a subset of primary and secondary glioblastoma multiforme. Adoptive transfer of genetically modified chimeric-antigen receptor (CAR) lymphocytes has demon
Autor:
Harshini Chinnasamy, Todd D. Prickett, Li Jia, Paul F. Robbins, Isaac R. Kriley, Yasmine Assadipour, Steven A. Rosenberg, Steven A. Feldman, Stephanie L. Goff, Jared J. Gartner, Nikolaos Zacharakis, Jessica S. Crystal, John R. Wunderlich, Yong-Chen Lu, Robert Somerville, Mary A. Black, Lily Lu, Hui Xu, Zhili Zheng
Publikováno v:
Clinical Cancer Research. 23:4347-4353
Purpose: The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There are limite
Autor:
Todd D. Prickett, Eric Tran, Anna Pasetto, Scott Kivitz, Steven A. Rosenberg, Paul F. Robbins, Drew C. Deniger, Parisa Malekzadeh, Isaac R. Kriley, Yong-Chen Lu, Maria R. Parkhurst, David S. Schrump, Satyajit Ray, Winifred Lo, Jared J. Gartner, Biman C. Paria, Li Jia, Thomas E. Shelton
Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545b9e388fee4a1d712a26bafe68f5c0
https://europepmc.org/articles/PMC6685528/
https://europepmc.org/articles/PMC6685528/
Autor:
Anna Pasetto, Zhili Zheng, Paul F. Robbins, Jared J. Gartner, Steven A. Feldman, Harshini Chinnasamy, Michelle M. Langhan, Stephanie L. Goff, Nikolaos Zacharakis, Li Jia, Yong-Chen Lu, Steven A. Rosenberg, Katarzyna Trebska-McGowan, Todd D. Prickett, Hui Xu, Robert Somerville, Mary A. Black, Thomas E. Shelton
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-induced lung cancers and bladder cancer—w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc31464c573e58f95d626fcf15186b8
https://europepmc.org/articles/PMC6348479/
https://europepmc.org/articles/PMC6348479/
Autor:
Linda L. Parker, Richard M. Sherry, Steven A. Rosenberg, Yong-Chen Lu, Christopher A. Klebanoff, Stephanie L. Goff, Zhili Zheng, Udai S. Kammula, Mary Ann Toomey, Xin Yao, Steven A. Feldman, Paul F. Robbins, Donald E. White, Yong F. Li, James Chih-Hsin Yang, Pierre van der Bruggen, Tangying Lu
Purpose Adoptive transfer of genetically modified T cells is being explored as a treatment for patients with metastatic cancer. Most current strategies use genes that encode major histocompatibility complex (MHC) class I–restricted T-cell receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a29796472156108031793a302320dd0
https://europepmc.org/articles/PMC5652397/
https://europepmc.org/articles/PMC5652397/
Autor:
Steven A. Rosenberg, Zhili Zheng, Todd D. Prickett, Yong-Chen Lu, Eric M. Groh, Paul F. Robbins, Jared J. Gartner, Eric Tran, Isaac R. Kriley, Li Jia, Anna Pasetto, Satyajit Ray
Publikováno v:
The New England journal of medicine. 375(23)
We identified a polyclonal CD8+ T-cell response against mutant KRAS G12D in tumor-infiltrating lymphocytes obtained from a patient with metastatic colorectal cancer. We observed objective regression of all seven lung metastases after the infusion of
Autor:
Alena Gros, Steven A. Rosenberg, Zhili Zheng, Yong F. Li, Satyajit Ray, Robert Somerville, John R. Wunderlich, Jared J. Gartner, Yong-Chen Lu, Simon Turcotte, Paul F. Robbins, Eric Tran, Mojgan Ahmadzadeh
Publikováno v:
Science
It is unknown whether the human immune system frequently mounts a T cell response against mutations expressed by common epithelial cancers. Using a next-generation sequencing approach combined with high-throughput immunologic screening, we demonstrat
Autor:
Steven A. Rosenberg, Simon Turcotte, Maria R. Parkhurst, Paul F. Robbins, John R. Wunderlich, Robert Somerville, Alena Gros, Yong-Chen Lu, Katherine Hogan, Eric Tran, James Chih-Hsin Yang, Mark E. Dudley, Christian S. Hinrichs
Publikováno v:
Science (New York, N.Y.). 344(6184)
T Cells for Epithelial Tumors Malignant tumors harbor genetic alterations. Recently, adoptive T cell therapies have taken advantage of this: T cells specific for mutations in tumors are infused into patients to generate an antitumor immune response.