Zobrazeno 1 - 10
of 84
pro vyhledávání: '"William R. Wilson"'
Autor:
William R. Wilson, Catherine S Y Lecat, Neil Rabin, Jonathan Sive, Lydia Lee, Ashutosh D. Wechalekar, Brendan Wisniowski, Ke Xu, Louise Ainley, Xenofon Papanikolaou, Shameem Mahmood, Lara Howells, Emma Dowling, Nuno Correia, Charalampia Kyriakou, Kwee Yong, Selina J Chavda, Emilie Sanchez, Annabel McMillan, Wei Yee Chan, Rakesh Popat, Eleni Nastouli
Publikováno v:
British Journal of Haematology
Autor:
Gary Cook, William R. Wilson, Pierre L. Martin-Hirsch, Naveena Singh, Sudha Sundar, Tara Barwick, Andrea Rockall, Dow-Mu Koh, Katja N. De Paepe, Christina Fotopoulou, Marielle Nobbenhuis, Victoria Warbey, Nishat Bharwani, Anju Sahdev, Aslam Sohaib, Marc E. Miquel, Helen F. Stringfellow, Allan Hackshaw, Ranjit Manchanda, Sadaf Ghaem-Maghami
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(23)
Purpose: Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare nodal staging accuracy of 18F-ethyl-choline-(FEC)-PET/CT, 18F-fluoro-deoxy-glucose-(FDG)-PET/CT, an
Autor:
Richard G. Jenner, Roger G. Owen, Lydia Eccersley, Laura Clifton-Hadley, Rakesh Popat, William R. Wilson, Elizabeth H Phillips, Selina J Chavda, Kwee Yong, Marie Scully, Michael Sheaff, Matthew Streetly, Gavin Pang, Karthik Ramasamy, Ceri Bygrave, Andres Virchis, James D. Cavenagh, Jonathan Sive, Gordon Cook, Sumaiya Kamora, Marquita Camilleri, Maria José Cuadrado, Michael A Chapman, Reuben Benjamin
Publikováno v:
Phillips, E 2021, ' Thrombotic microangiopathy in untreated myeloma patients receiving carfilzomib, cyclophosphamide and dexamethasone on the CARDAMON study. ', British Journal of Haematology, vol. 193, no. 4, pp. 750-760 . https://doi.org/10.1111/bjh.17377
Proteasome inhibitors have been associated with thrombotic microangiopathy (TMA) - a group of disorders characterised by occlusive microvascular thrombosis causing microangiopathic haemolytic anaemia, thrombocytopenia and end-organ damage. To date, c
Autor:
Simon Rule, William R. Wilson, Richard Lush, Deborah Turner, Andrew P. Haynes, Laura Clifton-Hadley, Mark Bishton, Andrew McMillan, Russell Patmore
Publikováno v:
British journal of haematologyReferences. 190(4)
We present a long-term follow-up of the UK chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced, symptomatic follicular lymphoma (FL). This trial was the first to prospecti
Autor:
William R. Wilson, Ralph J. Stevenson, Cho R. Hong, Stephen M. F. Jamieson, Wen Qi, Avik Shome, Yongchuan Gu, Robert F. Anderson, Way W. Wong, Muriel Bonnet, Michael P. Hay, Jingli Wang, Kevin O. Hicks, Frederik B. Pruijn, Lydia P. Liew
Publikováno v:
Journal of Medicinal Chemistry. 61:1241-1254
Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio-immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers. The role of hypoxic tumor cells in resistance to
Publikováno v:
International Journal of Pharmaceutics. 516:323-333
This paper aims to develop and evaluate a pH-sensitive PEGylated liposomal (pPSL) system for tumor-targeted intracellular delivery of SN25860, a weakly acidic, poorly water-soluble dinitrobenzamide mustard prodrug which is activated by the E. coli ni
Autor:
Kathryn Evans, Raushan T. Kurmasheva, William R. Wilson, Donya Moradi Manesh, Ashlee Hedrick, Catherine A. Billups, Cara E. Toscan, Hernan Carol, Peter J. Houghton, Glenn M. Marshall, Jennifer Richmond, Rosemary Sutton, Lauryn S. Bracken, Jad El-Hoss, Malcolm A. Smith, Richard B. Lock
Publikováno v:
Blood. 126:1193-1202
PR-104, a phosphate ester of the nitrogen mustard prodrug PR-104A, has shown evidence of efficacy in adult leukemia clinical trials. Originally designed to target hypoxic cells, PR-104A is independently activated by aldo-keto-reductase 1C3 (AKR1C3).
Autor:
Reidar Grénman, John Nemunaitis, Mark Zaidi, William R. Wilson, Courtney R. H. Lynch, Trevor D. McKee, Cho R. Hong, Peter Tsai, Charles P. Hart, Dennis Kee, Purvi M. Kakadia, John M. Chaplin, Tet Woo Lee, Bradly G. Wouters, Stephen M. F. Jamieson, Arthur Liu, Nicholas P. McIvor, Francis W. Hunter, Shadia I. Jalal, Cristin G. Print, Nicholas Knowlton, E. Gabriela Chiorean, Nooriyah Poonawala-Lohani, Way W. Wong, Kevin O. Hicks, Dan Li, Laura Caporiccio, Neil Senzer, Avik Shome, Michael A. Curran, Andrew Macann, Pratha Budhani, Maria Kondratyev, Stefan K. Bohlander, Sehrish Butt
Publikováno v:
JCI Insight. 3(16)
Evofosfamide (TH-302) is a clinical-stage hypoxia-activated prodrug of a DNA-crosslinking nitrogen mustard that has potential utility for human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC), in which tumor hypoxia limits
Autor:
William R. Wilson, Naval Daver, Peter F. Thall, Hagop M. Kantarjian, Tapan M. Kadia, Naveen Pemmaraju, Jennie Feliu, Andrew Coveler, John Gutheil, Sergej Konoplev, Caimiao Wei, Carlos E. Bueso-Ramos, Stefan Faderl, Hongbo Lu, Cecilia Arana Yi, Hoang Q. Nguyen, Juliana Benito, Farhad Ravandi, Jorge E. Cortes, Deborah A. Thomas, Yongchuan Gu, Michael Andreeff, Teresa J. Melink, Marina Konopleva, Elihu H. Estey, Elias Jabbour, Steven M. Kornblau, Gautam Borthakur
Publikováno v:
Haematologica. 100:927-934
We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using hypoxia-activated prodrugs. PR104 is a phosphate ester that is rapidly hydrolyzed in vivo to the corresponding alcohol PR-1
Autor:
Kevin O. Hicks, William R. Wilson, Michael P. Hay, Jagdish K. Jaiswal, Jingli Wang, Yongchuan Gu
Publikováno v:
Journal of Pharmaceutical Sciences. 103:3464-3472
SN30000 is a benzotriazine di-N-oxide which is selectively toxic to radio-resistant hypoxic cells in tumours. Given the complex photochemistry of some aromatic N-oxides, we evaluated the potential for photodegradation of SN30000 solutions. Initial st