Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Wei-Yi Ong"'
Autor:
Peiyan Wong, Wei Lun Seow, Wee Siong Chew, Deron R. Herr, Wei Wang, Federico Torta, Wei-Yi Ong, Ping Xiang, Jing Kai Chang, Raghav Sundar, Aishwarya Bandla, Markus R. Wenk, Brenda Wan Shing Lam, Kanokporn Chayaburakul, Violeta Lopez
Publikováno v:
Journal of Biological Chemistry. 295:1143-1152
Platinum-based therapeutics are used to manage many forms of cancer, but frequently result in peripheral neuropathy. Currently, the only option available to attenuate chemotherapy-induced neuropathy is to limit or discontinue this treatment. Sphingos
Autor:
Greg N. Carlson, Mary F. McMullen, Sookhee Bang, Hala Kazi, Mei Xuan Ho, Konrad Talbot, Yong Chen, Sangwon F. Kim, Steven E. Arnold, Wei-Yi Ong
Publikováno v:
Molecular neurobiology. 54(3)
Schizophrenia is a chronic deliberating neuropsychiatric disorder that affects about 1% of the population. Dystrobrevin-binding protein 1 (DTNBP1 or dysbindin) is one of Research Domain Constructs (RDoC) associated with cognition and is significantly
Publikováno v:
Neuroscience Bulletin. 26:197-204
Cholesterol 24-hydroxylase catalyzes the conversion of cholesterol to 24-hydroxycholesterol, which is a major pathway for cholesterol elimination from the brain, since 24-hydroxycholesterol can readily cross the blood brain barrier. The present study
Autor:
Sung Youl Lee, Hyoung-Chun Kim, Myung-Bok Wie, The-Vinh Tran, Chun Kee Chung, Eun-Joo Shin, Yoon Hee Chung, Ji Hoon Jeong, Wei-Yi Ong, Hwa-Jung Kim, Eon Sub Park, Dae-Joong Kim, Yunsung Nam
Publikováno v:
Free radical biologymedicine. 84
To determine the role of ceruloplasmin (Cp) in epileptic seizures, we used a kainate (KA) seizure animal model and examined hippocampal samples from epileptic patients. Treatment with KA resulted in a time-dependent decrease in Cp protein expression
Publikováno v:
Journal of Neurocytology. 34:447-458
The present study was carried out to elucidate the distribution of calcium-independent phospholipase A(2) (iPLA(2)) in the normal monkey brain. iPLA(2) immunoreactivity was observed in structures derived from the telencephalon, including the cerebral
Publikováno v:
Neuroscience. 128:487-496
An accumulation of iron occurs in the brain with age, and it is thought that this may contribute to the pathology of certain neurodegenerative diseases, including Parkinson's disease. In this study, we elucidated the distribution of divalent metal tr
Publikováno v:
Journal of neurochemistry. 129(2)
Gain-of-toxic-function mutations in Seipin (Asparagine 88 to Serine (N88S) and Serine 90 to Leucine (S90L) mutations, both of which disrupt the N-glycosylation) cause autosomal dominant motor neuron diseases. However, the mechanism of how these misse
Autor:
Edward B. Neufeld, Peter G. Pentchev, S Suresh, Ramesh C. Patel, Wei-Yi Ong, C. Y. Hu, Roscoe O. Brady, Yogesh C. Patel, Adele Cooney, E J Blanchette-Mackie, Shutish C. Patel, Ujendra Kumar
Publikováno v:
Proceedings of the National Academy of Sciences. 96:1657-1662
Niemann–Pick type C disease (NP-C) is an inherited neurovisceral lipid storage disorder characterized by progressive neurodegeneration. Most cases of NP-C result from inactivating mutations of NPC1 , a recently identified member of a family of gene
Publikováno v:
Experimental Brain Research. 119:367-374
Specimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy, using antibodies to the metabotropic glutamate receptor subunit mGluR1a and the ionotropic glutamate receptor
Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice
Autor:
Gunter P. Eckert, W. Gibson Wood, Urule Igbavboa, Gero P. Hooff, Wei-Yi Ong, Walter E. Müller, Ji-Hyun Kim
Publikováno v:
Molecular neurobiology. 46(1)
The mevalonate/isoprenoids/cholesterol pathway has a fundamental role in the brain. Increasing age could be associated with specific changes in mevalonate downstream products. Other than age differences in brain cholesterol and dolichol levels, there